Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 35 studies | 38% ± 15% | |
classical monocyte | 22 studies | 31% ± 11% | |
macrophage | 21 studies | 36% ± 18% | |
monocyte | 17 studies | 35% ± 19% | |
non-classical monocyte | 16 studies | 29% ± 11% | |
endothelial cell of lymphatic vessel | 15 studies | 37% ± 18% | |
astrocyte | 15 studies | 44% ± 20% | |
fibroblast | 15 studies | 34% ± 14% | |
ciliated cell | 14 studies | 31% ± 15% | |
capillary endothelial cell | 14 studies | 26% ± 11% | |
microglial cell | 14 studies | 49% ± 16% | |
pericyte | 12 studies | 31% ± 17% | |
type I pneumocyte | 10 studies | 39% ± 17% | |
neutrophil | 10 studies | 28% ± 9% | |
myeloid cell | 10 studies | 42% ± 17% | |
glutamatergic neuron | 9 studies | 48% ± 24% | |
adipocyte | 9 studies | 37% ± 9% | |
smooth muscle cell | 9 studies | 29% ± 8% | |
oligodendrocyte | 9 studies | 28% ± 10% | |
GABAergic neuron | 8 studies | 41% ± 20% | |
B cell | 8 studies | 26% ± 9% | |
endothelial cell of artery | 8 studies | 20% ± 5% | |
oligodendrocyte precursor cell | 8 studies | 30% ± 12% | |
epithelial cell | 8 studies | 42% ± 20% | |
basal cell | 7 studies | 32% ± 17% | |
dendritic cell | 7 studies | 42% ± 12% | |
mast cell | 7 studies | 25% ± 9% | |
conventional dendritic cell | 6 studies | 28% ± 15% | |
neuron | 6 studies | 41% ± 19% | |
club cell | 6 studies | 31% ± 12% | |
type II pneumocyte | 6 studies | 39% ± 10% | |
interneuron | 5 studies | 43% ± 21% | |
amacrine cell | 5 studies | 20% ± 6% | |
retinal cone cell | 5 studies | 30% ± 10% | |
mononuclear phagocyte | 5 studies | 36% ± 14% | |
vein endothelial cell | 5 studies | 34% ± 17% | |
lymphocyte | 5 studies | 22% ± 5% | |
Mueller cell | 5 studies | 43% ± 5% | |
endothelial cell of vascular tree | 5 studies | 34% ± 17% | |
goblet cell | 5 studies | 32% ± 26% | |
naive B cell | 4 studies | 18% ± 2% | |
granule cell | 4 studies | 32% ± 9% | |
cardiac muscle cell | 4 studies | 22% ± 4% | |
retinal rod cell | 4 studies | 21% ± 3% | |
hepatocyte | 4 studies | 57% ± 17% | |
connective tissue cell | 4 studies | 25% ± 4% | |
brush cell | 4 studies | 27% ± 9% | |
T cell | 4 studies | 27% ± 11% | |
alveolar macrophage | 4 studies | 52% ± 21% | |
secretory cell | 3 studies | 21% ± 4% | |
glomerular endothelial cell | 3 studies | 25% ± 0% | |
glial cell | 3 studies | 25% ± 2% | |
plasma cell | 3 studies | 35% ± 3% | |
endocardial cell | 3 studies | 39% ± 13% | |
mesothelial cell | 3 studies | 34% ± 12% | |
glycinergic amacrine cell | 3 studies | 23% ± 1% | |
retinal pigment epithelial cell | 3 studies | 39% ± 29% | |
enteroendocrine cell | 3 studies | 23% ± 5% | |
respiratory goblet cell | 3 studies | 47% ± 14% | |
mucus secreting cell | 3 studies | 45% ± 10% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 16 studies | 36% ± 18% | |
lung | 11 studies | 31% ± 12% | |
eye | 7 studies | 26% ± 16% | |
peripheral blood | 5 studies | 24% ± 6% | |
heart | 4 studies | 29% ± 5% | |
liver | 4 studies | 34% ± 17% | |
adipose | 4 studies | 32% ± 12% | |
intestine | 3 studies | 22% ± 5% | |
kidney | 3 studies | 29% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 6656.10 | 21 / 21 | 100% | 21.55 | 504 / 504 |
esophagus | 100% | 5825.06 | 1445 / 1445 | 100% | 32.77 | 183 / 183 |
intestine | 100% | 6309.65 | 966 / 966 | 100% | 26.48 | 527 / 527 |
kidney | 100% | 5763.00 | 89 / 89 | 100% | 32.98 | 901 / 901 |
lung | 100% | 8949.66 | 578 / 578 | 100% | 26.80 | 1155 / 1155 |
ovary | 100% | 5426.01 | 180 / 180 | 100% | 18.86 | 430 / 430 |
prostate | 100% | 5193.85 | 245 / 245 | 100% | 21.78 | 502 / 502 |
stomach | 100% | 4203.23 | 359 / 359 | 100% | 25.41 | 286 / 286 |
uterus | 100% | 6534.59 | 170 / 170 | 100% | 22.37 | 459 / 459 |
breast | 100% | 5837.00 | 459 / 459 | 100% | 26.43 | 1115 / 1118 |
thymus | 100% | 5984.96 | 653 / 653 | 100% | 23.63 | 603 / 605 |
pancreas | 100% | 3047.98 | 328 / 328 | 99% | 28.15 | 177 / 178 |
skin | 100% | 5859.57 | 1809 / 1809 | 99% | 20.84 | 466 / 472 |
liver | 100% | 3889.50 | 226 / 226 | 98% | 14.08 | 399 / 406 |
brain | 98% | 2802.07 | 2581 / 2642 | 100% | 15.60 | 704 / 705 |
adrenal gland | 100% | 4030.35 | 258 / 258 | 97% | 14.96 | 222 / 230 |
adipose | 100% | 5859.65 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5009.92 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.43 | 29 / 29 |
spleen | 100% | 6631.02 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 21.83 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.91 | 1 / 1 |
peripheral blood | 100% | 10927.62 | 927 / 929 | 0% | 0 | 0 / 0 |
heart | 100% | 2974.29 | 859 / 861 | 0% | 0 | 0 / 0 |
muscle | 99% | 1957.51 | 791 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 13.31 | 76 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0034332 | Biological process | adherens junction organization |
GO_0050769 | Biological process | positive regulation of neurogenesis |
GO_0007409 | Biological process | axonogenesis |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0021670 | Biological process | lateral ventricle development |
GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
GO_0021849 | Biological process | neuroblast division in subventricular zone |
GO_1903077 | Biological process | negative regulation of protein localization to plasma membrane |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0005769 | Cellular component | early endosome |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0005925 | Cellular component | focal adhesion |
GO_0005737 | Cellular component | cytoplasm |
GO_0010008 | Cellular component | endosome membrane |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0045177 | Cellular component | apical part of cell |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0045294 | Molecular function | alpha-catenin binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NUMB |
Protein name | NUMB endocytic adaptor protein Protein numb homolog (h-Numb) (Protein S171) |
Synonyms | C14orf41 |
Description | FUNCTION: Regulates clathrin-mediated receptor endocytosis . Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). . |
Accessions | ENST00000555238.6 [P49757-1] ENST00000556772.5 ENST00000554521.6 [P49757-8] ENST00000554546.5 [P49757-4] ENST00000555738.6 [P49757-6] ENST00000535282.5 [P49757-2] G3V4S6 ENST00000356296.8 [P49757-2] ENST00000559312.5 [P49757-7] G3V3Z8 ENST00000544991.7 [P49757-7] ENST00000555859.5 G3V3R1 ENST00000554394.5 ENST00000560335.5 [P49757-5] ENST00000554818.5 ENST00000555307.5 ENST00000355058.7 [P49757-1] G3V3M5 ENST00000555394.5 [P49757-2] ENST00000555987.5 G3V433 P49757 ENST00000557597.5 [P49757-3] ENST00000359560.7 [P49757-3] |