NUMB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034332Biological processadherens junction organization
GO_0050769Biological processpositive regulation of neurogenesis
GO_0007409Biological processaxonogenesis
GO_0030335Biological processpositive regulation of cell migration
GO_0021670Biological processlateral ventricle development
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0021849Biological processneuroblast division in subventricular zone
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005769Cellular componentearly endosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0045177Cellular componentapical part of cell
GO_0016323Cellular componentbasolateral plasma membrane
GO_0045294Molecular functionalpha-catenin binding
GO_0045296Molecular functioncadherin binding
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUMB
Protein nameNUMB endocytic adaptor protein
Protein numb homolog (h-Numb) (Protein S171)
SynonymsC14orf41
DescriptionFUNCTION: Regulates clathrin-mediated receptor endocytosis . Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). .

AccessionsENST00000555238.6 [P49757-1]
ENST00000556772.5
ENST00000554521.6 [P49757-8]
ENST00000554546.5 [P49757-4]
ENST00000555738.6 [P49757-6]
ENST00000535282.5 [P49757-2]
G3V4S6
ENST00000356296.8 [P49757-2]
ENST00000559312.5 [P49757-7]
G3V3Z8
ENST00000544991.7 [P49757-7]
ENST00000555859.5
G3V3R1
ENST00000554394.5
ENST00000560335.5 [P49757-5]
ENST00000554818.5
ENST00000555307.5
ENST00000355058.7 [P49757-1]
G3V3M5
ENST00000555394.5 [P49757-2]
ENST00000555987.5
G3V433
P49757
ENST00000557597.5 [P49757-3]
ENST00000359560.7 [P49757-3]