SHC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHC1 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0007507Biological processheart development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0071363Biological processcellular response to growth factor stimulus
GO_0030036Biological processactin cytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042742Biological processdefense response to bacterium
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0098609Biological processcell-cell adhesion
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0070435Cellular componentShc-EGFR complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005158Molecular functioninsulin receptor binding
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0005543Molecular functionphospholipid binding
GO_0046875Molecular functionephrin receptor binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0048408Molecular functionepidermal growth factor binding
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0005168Molecular functionneurotrophin TRKA receptor binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameSHC1
Protein nameSHC adaptor protein 1
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1)
SynonymsSHCA
SHC
DescriptionFUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. .

AccessionsENST00000414115.5
Q5T188
ENST00000444179.5
H0Y539
ENST00000368450.5 [P29353-2]
Q5T181
ENST00000368445.9 [P29353-1]
X6R6D0
P29353
ENST00000368449.8
Q5T182
ENST00000366442.2
ENST00000448116.7 [P29353-6]
Q5T187
ENST00000368453.8 [P29353-7]
ENST00000444664.5
ENST00000412170.5