DDR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035994Biological processresponse to muscle stretch
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0090091Biological processpositive regulation of extracellular matrix disassembly
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0010976Biological processpositive regulation of neuron projection development
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0007165Biological processsignal transduction
GO_0010763Biological processpositive regulation of fibroblast migration
GO_0035988Biological processchondrocyte proliferation
GO_0007275Biological processmulticellular organism development
GO_0038063Biological processcollagen-activated tyrosine kinase receptor signaling pathway
GO_0030500Biological processregulation of bone mineralization
GO_0007155Biological processcell adhesion
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0010715Biological processregulation of extracellular matrix disassembly
GO_0045860Biological processpositive regulation of protein kinase activity
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0033674Biological processpositive regulation of kinase activity
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0031214Biological processbiomineral tissue development
GO_0034103Biological processregulation of tissue remodeling
GO_1901299Biological processnegative regulation of hydrogen peroxide-mediated programmed cell death
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030199Biological processcollagen fibril organization
GO_0001503Biological processossification
GO_1904899Biological processpositive regulation of hepatic stellate cell proliferation
GO_0046777Biological processprotein autophosphorylation
GO_2000491Biological processpositive regulation of hepatic stellate cell activation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0003416Biological processendochondral bone growth
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0071456Biological processcellular response to hypoxia
GO_1904385Biological processcellular response to angiotensin
GO_0090303Biological processpositive regulation of wound healing
GO_0016324Cellular componentapical plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0015629Cellular componentactin cytoskeleton
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0038062Molecular functionprotein tyrosine kinase collagen receptor activity
GO_0005524Molecular functionATP binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDDR2
Protein nameDiscoidin domain receptor tyrosine kinase 2
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
SynonymsTYRO10
TKT
NTRKR3
DescriptionFUNCTION: Tyrosine kinase involved in the regulation of tissues remodeling . It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. .

AccessionsENST00000367922.7
Q5T244
ENST00000671979.1
ENST00000415555.5
A0A5F9ZI27
ENST00000367921.8
ENST00000446985.6
Q16832