USP33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0006897Biological processendocytosis
GO_0051298Biological processcentrosome duplication
GO_0032092Biological processpositive regulation of protein binding
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0009267Biological processcellular response to starvation
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0010506Biological processregulation of autophagy
GO_0050821Biological processprotein stabilization
GO_0016579Biological processprotein deubiquitination
GO_0032091Biological processnegative regulation of protein binding
GO_0016477Biological processcell migration
GO_0007411Biological processaxon guidance
GO_0030891Cellular componentVCB complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUSP33
Protein nameUbiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Ubiquitin specific peptidase 33
SynonymsKIAA1097
VDU1
DescriptionFUNCTION: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .

AccessionsENST00000527390.1
ENST00000370794.7 [Q8TEY7-2]
E9PQP0
Q8TEY7
ENST00000524778.1
E9PP47
ENST00000357428.5 [Q8TEY7-1]
ENST00000370792.7 [Q8TEY7-3]
E9PLK7
ENST00000481579.5
ENST00000370793.5 [Q8TEY7-1]
ENST00000530709.5
H0YD08
H0YCV3
ENST00000524536.5