CASK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046037Biological processGMP metabolic process
GO_0061045Biological processnegative regulation of wound healing
GO_0090288Biological processnegative regulation of cellular response to growth factor stimulus
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0046710Biological processGDP metabolic process
GO_0007155Biological processcell adhesion
GO_0051649Biological processestablishment of localization in cell
GO_0046928Biological processregulation of neurotransmitter secretion
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0070509Biological processcalcium ion import
GO_0008104Biological processprotein localization
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0090280Biological processpositive regulation of calcium ion import
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005730Cellular componentnucleolus
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0005925Cellular componentfocal adhesion
GO_0060170Cellular componentciliary membrane
GO_0005911Cellular componentcell-cell junction
GO_0016363Cellular componentnuclear matrix
GO_0015629Cellular componentactin cytoskeleton
GO_0005652Cellular componentnuclear lamina
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005604Cellular componentbasement membrane
GO_0031982Cellular componentvesicle
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042043Molecular functionneurexin family protein binding
GO_0004385Molecular functionguanylate kinase activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASK
Protein nameCalcium/calmodulin-dependent serin protein kinase
Calcium/calmodulin dependent serine protein kinase (Peripheral plasma membrane protein CASK)
Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Calcium/calmodulin dependent serine protein kinase
Calcium/calmodulin dependent serine protein kinase (Calcium/calmodulin-dependent serine protein kinase (MAGUK family), isoform CRA_c)
SynonymshCG_1987160
LIN2
DescriptionFUNCTION: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking . Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). .

AccessionsENST00000421587.8
ENST00000643043.2
ENST00000378168.8
ENST00000486402.1
ENST00000378166.9
ENST00000645566.1 [O14936-2]
A0A2R8Y3B3
B7ZKY2
ENST00000646087.2
ENST00000643831.2
A0A2R8YGH2
A0A2R8YE77
ENST00000378154.3 [O14936-6]
A0A2R8Y472
ENST00000645986.2
ENST00000646120.2 [O14936-4]
ENST00000644770.1
ENST00000675354.1
A0A2U3TZN6
A0A2R8YFN5
ENST00000642361.2
Q5JS79
ENST00000442742.7
A0A2R8Y6D8
O14936
ENST00000646120
A0A2R8Y6F8
A0A2R8YEJ7
ENST00000644347.1 [O14936-3]
A0A7I2RJN6
A0A2R8Y4K4
A0A0B6XJY0
A0A2U3TZM4
ENST00000378158.6
A0A2U3TZM1
A0A2R8YEK3
ENST00000643733.1
ENST00000647118.2
ENST00000644219.1
ENST00000378163.7 [O14936-1]
A0A2R8Y7X6