Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 16 studies | 31% ± 14% | |
| astrocyte | 15 studies | 38% ± 16% | |
| oligodendrocyte precursor cell | 15 studies | 63% ± 21% | |
| glutamatergic neuron | 12 studies | 48% ± 24% | |
| microglial cell | 11 studies | 31% ± 13% | |
| fibroblast | 11 studies | 37% ± 13% | |
| GABAergic neuron | 10 studies | 54% ± 23% | |
| epithelial cell | 10 studies | 30% ± 7% | |
| oligodendrocyte | 10 studies | 26% ± 12% | |
| adipocyte | 9 studies | 32% ± 8% | |
| pericyte | 8 studies | 30% ± 16% | |
| T cell | 7 studies | 37% ± 14% | |
| macrophage | 7 studies | 34% ± 13% | |
| endothelial cell of lymphatic vessel | 7 studies | 31% ± 11% | |
| CD4-positive, alpha-beta T cell | 6 studies | 34% ± 14% | |
| interneuron | 6 studies | 63% ± 13% | |
| regulatory T cell | 6 studies | 36% ± 21% | |
| type II pneumocyte | 6 studies | 37% ± 11% | |
| neuron | 5 studies | 58% ± 21% | |
| basal cell | 5 studies | 27% ± 11% | |
| amacrine cell | 5 studies | 31% ± 11% | |
| retinal ganglion cell | 5 studies | 36% ± 24% | |
| mast cell | 5 studies | 21% ± 5% | |
| smooth muscle cell | 5 studies | 27% ± 4% | |
| type I pneumocyte | 5 studies | 28% ± 7% | |
| effector memory CD8-positive, alpha-beta T cell | 4 studies | 39% ± 13% | |
| B cell | 4 studies | 26% ± 7% | |
| CD8-positive, alpha-beta T cell | 4 studies | 27% ± 8% | |
| retina horizontal cell | 4 studies | 34% ± 13% | |
| club cell | 4 studies | 29% ± 9% | |
| natural killer cell | 4 studies | 21% ± 4% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 37% ± 13% | |
| kidney loop of Henle epithelial cell | 3 studies | 19% ± 4% | |
| GABAergic interneuron | 3 studies | 54% ± 16% | |
| granule cell | 3 studies | 40% ± 13% | |
| progenitor cell | 3 studies | 44% ± 11% | |
| mesothelial cell | 3 studies | 28% ± 5% | |
| GABAergic amacrine cell | 3 studies | 50% ± 14% | |
| glycinergic amacrine cell | 3 studies | 40% ± 14% | |
| retinal rod cell | 3 studies | 33% ± 14% | |
| rod bipolar cell | 3 studies | 29% ± 12% | |
| ependymal cell | 3 studies | 40% ± 21% | |
| intestinal crypt stem cell | 3 studies | 24% ± 5% | |
| ciliated cell | 3 studies | 23% ± 6% | |
| monocyte | 3 studies | 22% ± 3% | |
| lymphocyte | 3 studies | 55% ± 15% | |
| leukocyte | 3 studies | 51% ± 14% | |
| transit amplifying cell | 3 studies | 31% ± 15% | |
| dendritic cell | 3 studies | 21% ± 3% | |
| mucus secreting cell | 3 studies | 27% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1618.70 | 1445 / 1445 | 100% | 19.29 | 183 / 183 |
| brain | 100% | 1998.02 | 2640 / 2642 | 100% | 21.76 | 703 / 705 |
| intestine | 100% | 2142.12 | 966 / 966 | 99% | 16.51 | 524 / 527 |
| stomach | 100% | 1788.90 | 359 / 359 | 99% | 18.80 | 283 / 286 |
| pancreas | 100% | 1190.76 | 328 / 328 | 98% | 11.19 | 175 / 178 |
| breast | 100% | 1833.06 | 459 / 459 | 98% | 14.28 | 1097 / 1118 |
| lung | 100% | 1742.80 | 578 / 578 | 98% | 12.98 | 1133 / 1155 |
| bladder | 100% | 1819.38 | 21 / 21 | 96% | 11.54 | 482 / 504 |
| uterus | 100% | 1866.95 | 170 / 170 | 95% | 9.77 | 434 / 459 |
| prostate | 100% | 1584.27 | 245 / 245 | 94% | 6.30 | 471 / 502 |
| kidney | 100% | 1207.00 | 89 / 89 | 86% | 7.54 | 776 / 901 |
| skin | 100% | 1908.53 | 1809 / 1809 | 81% | 5.56 | 381 / 472 |
| thymus | 100% | 1328.70 | 652 / 653 | 80% | 4.63 | 486 / 605 |
| adrenal gland | 100% | 2003.43 | 258 / 258 | 80% | 5.68 | 184 / 230 |
| ovary | 100% | 2141.52 | 180 / 180 | 80% | 4.78 | 343 / 430 |
| liver | 100% | 741.08 | 226 / 226 | 69% | 4.79 | 280 / 406 |
| adipose | 100% | 1510.98 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2217.09 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1473.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.12 | 1 / 1 |
| muscle | 97% | 581.69 | 780 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 8.98 | 43 / 45 |
| heart | 94% | 725.11 | 811 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 48% | 333.25 | 443 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 2.25 | 13 / 29 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.78 | 16 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046037 | Biological process | GMP metabolic process |
| GO_0061045 | Biological process | negative regulation of wound healing |
| GO_0090288 | Biological process | negative regulation of cellular response to growth factor stimulus |
| GO_0001953 | Biological process | negative regulation of cell-matrix adhesion |
| GO_0046710 | Biological process | GDP metabolic process |
| GO_0007155 | Biological process | cell adhesion |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0046928 | Biological process | regulation of neurotransmitter secretion |
| GO_0010839 | Biological process | negative regulation of keratinocyte proliferation |
| GO_0070509 | Biological process | calcium ion import |
| GO_0008104 | Biological process | protein localization |
| GO_2000300 | Biological process | regulation of synaptic vesicle exocytosis |
| GO_0090280 | Biological process | positive regulation of calcium ion import |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005730 | Cellular component | nucleolus |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0060170 | Cellular component | ciliary membrane |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0016363 | Cellular component | nuclear matrix |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005652 | Cellular component | nuclear lamina |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005604 | Cellular component | basement membrane |
| GO_0031982 | Cellular component | vesicle |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042043 | Molecular function | neurexin family protein binding |
| GO_0004385 | Molecular function | guanylate kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CASK |
| Protein name | Calcium/calmodulin-dependent serin protein kinase Calcium/calmodulin dependent serine protein kinase (Peripheral plasma membrane protein CASK) Calcium/calmodulin-dependent serine protein kinase (MAGUK family) Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) Calcium/calmodulin dependent serine protein kinase Calcium/calmodulin dependent serine protein kinase (Calcium/calmodulin-dependent serine protein kinase (MAGUK family), isoform CRA_c) |
| Synonyms | hCG_1987160 LIN2 |
| Description | FUNCTION: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking . Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). . |
| Accessions | ENST00000421587.8 ENST00000643043.2 ENST00000378168.8 ENST00000486402.1 ENST00000378166.9 ENST00000645566.1 [O14936-2] A0A2R8Y3B3 B7ZKY2 ENST00000646087.2 ENST00000643831.2 A0A2R8YGH2 A0A2R8YE77 ENST00000378154.3 [O14936-6] A0A2R8Y472 ENST00000645986.2 ENST00000646120.2 [O14936-4] ENST00000644770.1 ENST00000675354.1 A0A2U3TZN6 A0A2R8YFN5 ENST00000642361.2 Q5JS79 ENST00000442742.7 A0A2R8Y6D8 O14936 ENST00000646120 A0A2R8Y6F8 A0A2R8YEJ7 ENST00000644347.1 [O14936-3] A0A7I2RJN6 A0A2R8Y4K4 A0A0B6XJY0 A0A2U3TZM4 ENST00000378158.6 A0A2U3TZM1 A0A2R8YEK3 ENST00000643733.1 ENST00000647118.2 ENST00000644219.1 ENST00000378163.7 [O14936-1] A0A2R8Y7X6 |