ARHGEF7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048013Biological processephrin receptor signaling pathway
GO_2000394Biological processpositive regulation of lamellipodium morphogenesis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0030032Biological processlamellipodium assembly
GO_0007165Biological processsignal transduction
GO_0010763Biological processpositive regulation of fibroblast migration
GO_1905833Biological processnegative regulation of microtubule nucleation
GO_0007030Biological processGolgi organization
GO_0048041Biological processfocal adhesion assembly
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0007266Biological processRho protein signal transduction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0007399Biological processnervous system development
GO_0001726Cellular componentruffle
GO_0097431Cellular componentmitotic spindle pole
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0043015Molecular functiongamma-tubulin binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARHGEF7
Protein nameRho guanine nucleotide exchange factor (GEF) 7, isoform CRA_f (Rho guanine nucleotide exchange factor 7)
ARHGEF7 protein
Rho guanine nucleotide exchange factor 7
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
ARHGEF7
SynonymshCG_1811466
KIAA0142
PIXB
COOL1
Nbla10314
P85SPR
PAK3BP
DescriptionFUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. .

AccessionsB1ALK7
ENST00000375741.6 [Q14155-4]
A0A8V8TQ72
ENST00000469877.5
C9JDI6
Q14155
E7EUY6
E7ENL8
ENST00000467053.5
ENST00000426073.6 [Q14155-1]
ENST00000466143.5
ENST00000375723.5 [Q14155-6]
Q5ZEZ2
Q5ZEZ3
ENST00000491775.5
ENST00000375739.6 [Q14155-2]
F6SJA5
ENST00000700426.1
ENST00000449979.5
A0A2X0SF98
C9JAD7
ENST00000375736.8 [Q14155-1]
ENST00000218789.9
ENST00000317133.9 [Q14155-3]
E9PDQ5
ENST00000544132.2
ENST00000478679.5
A0A2R8YG42
ENST00000426768.2
ENST00000646102.2
E7EU80
B1ANY6