PCBP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	49% ± 19%	Explore
B cell	44 studies	56% ± 23%	Explore
macrophage	43 studies	51% ± 19%	Explore
fibroblast	43 studies	50% ± 19%	Explore
natural killer cell	40 studies	54% ± 20%	Explore
T cell	37 studies	51% ± 24%	Explore
CD8-positive, alpha-beta T cell	35 studies	58% ± 23%	Explore
pericyte	34 studies	49% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	65% ± 21%	Explore
smooth muscle cell	31 studies	46% ± 20%	Explore
conventional dendritic cell	29 studies	72% ± 18%	Explore
regulatory T cell	27 studies	65% ± 20%	Explore
classical monocyte	26 studies	63% ± 19%	Explore
plasmacytoid dendritic cell	25 studies	70% ± 19%	Explore
epithelial cell	24 studies	57% ± 23%	Explore
dendritic cell	23 studies	64% ± 25%	Explore
endothelial cell of lymphatic vessel	23 studies	57% ± 21%	Explore
non-classical monocyte	23 studies	59% ± 19%	Explore
basal cell	22 studies	54% ± 20%	Explore
mast cell	21 studies	42% ± 18%	Explore
monocyte	21 studies	54% ± 19%	Explore
mature NK T cell	20 studies	52% ± 19%	Explore
memory B cell	20 studies	71% ± 14%	Explore
naive B cell	20 studies	63% ± 19%	Explore
gamma-delta T cell	18 studies	61% ± 19%	Explore
ciliated cell	18 studies	54% ± 21%	Explore
connective tissue cell	18 studies	59% ± 23%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	61% ± 19%	Explore
plasma cell	17 studies	51% ± 18%	Explore
mucosal invariant T cell	16 studies	56% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	57% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	64% ± 19%	Explore
myofibroblast cell	15 studies	60% ± 21%	Explore
myeloid cell	15 studies	58% ± 24%	Explore
astrocyte	15 studies	31% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	67% ± 16%	Explore
capillary endothelial cell	14 studies	46% ± 20%	Explore
endothelial cell of vascular tree	13 studies	51% ± 16%	Explore
type I pneumocyte	12 studies	42% ± 21%	Explore
type II pneumocyte	12 studies	49% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	52% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	68% ± 18%	Explore
secretory cell	12 studies	56% ± 15%	Explore
oligodendrocyte	12 studies	28% ± 10%	Explore
endothelial cell of artery	12 studies	55% ± 17%	Explore
mesothelial cell	12 studies	60% ± 29%	Explore
vein endothelial cell	12 studies	58% ± 20%	Explore
microglial cell	12 studies	28% ± 10%	Explore
plasmablast	11 studies	63% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	65% ± 23%	Explore
club cell	11 studies	47% ± 21%	Explore
leukocyte	11 studies	44% ± 17%	Explore
erythrocyte	11 studies	57% ± 30%	Explore
oligodendrocyte precursor cell	11 studies	33% ± 19%	Explore
innate lymphoid cell	10 studies	61% ± 15%	Explore
T follicular helper cell	10 studies	68% ± 20%	Explore
progenitor cell	10 studies	63% ± 26%	Explore
abnormal cell	10 studies	68% ± 21%	Explore
goblet cell	10 studies	46% ± 18%	Explore
glutamatergic neuron	9 studies	35% ± 20%	Explore
alveolar macrophage	8 studies	49% ± 23%	Explore
neutrophil	8 studies	43% ± 20%	Explore
platelet	8 studies	37% ± 16%	Explore
neuron	8 studies	56% ± 28%	Explore
retinal rod cell	8 studies	37% ± 14%	Explore
hematopoietic stem cell	8 studies	82% ± 18%	Explore
respiratory goblet cell	7 studies	42% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	66% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	55% ± 22%	Explore
renal alpha-intercalated cell	7 studies	55% ± 20%	Explore
enterocyte	7 studies	45% ± 22%	Explore
IgA plasma cell	7 studies	36% ± 10%	Explore
lymphocyte	7 studies	54% ± 31%	Explore
precursor B cell	7 studies	80% ± 23%	Explore
GABAergic neuron	7 studies	34% ± 16%	Explore
ionocyte	6 studies	52% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	66% ± 22%	Explore
mononuclear phagocyte	6 studies	55% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	49% ± 13%	Explore
erythroblast	6 studies	57% ± 34%	Explore
IgG plasma cell	6 studies	31% ± 5%	Explore
retinal cone cell	6 studies	44% ± 22%	Explore
immature B cell	6 studies	76% ± 15%	Explore
mucus secreting cell	6 studies	28% ± 7%	Explore
adipocyte	6 studies	26% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	67% ± 20%	Explore
hepatocyte	6 studies	47% ± 28%	Explore
CD4-positive helper T cell	5 studies	43% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	53% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	51% ± 18%	Explore
hematopoietic precursor cell	5 studies	80% ± 17%	Explore
exhausted T cell	5 studies	73% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	71% ± 19%	Explore
enteroendocrine cell	5 studies	63% ± 25%	Explore
transit amplifying cell	5 studies	53% ± 18%	Explore
pro-B cell	5 studies	82% ± 22%	Explore
brush cell	5 studies	42% ± 24%	Explore
T-helper 17 cell	5 studies	63% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	77% ± 12%	Explore
adventitial cell	5 studies	38% ± 12%	Explore
cardiac muscle cell	5 studies	23% ± 7%	Explore
double negative thymocyte	5 studies	79% ± 16%	Explore
intermediate monocyte	5 studies	67% ± 23%	Explore
granulocyte	5 studies	53% ± 16%	Explore
interneuron	5 studies	50% ± 22%	Explore
deuterosomal cell	4 studies	44% ± 14%	Explore
duct epithelial cell	4 studies	43% ± 19%	Explore
squamous epithelial cell	4 studies	41% ± 23%	Explore
pancreatic A cell	4 studies	67% ± 8%	Explore
type B pancreatic cell	4 studies	57% ± 15%	Explore
glomerular endothelial cell	4 studies	39% ± 9%	Explore
intestinal crypt stem cell	4 studies	55% ± 18%	Explore
OFF-bipolar cell	4 studies	29% ± 8%	Explore
ON-bipolar cell	4 studies	28% ± 9%	Explore
retinal ganglion cell	4 studies	51% ± 27%	Explore
retina horizontal cell	4 studies	34% ± 11%	Explore
retinal pigment epithelial cell	4 studies	48% ± 22%	Explore
glial cell	4 studies	49% ± 30%	Explore
Mueller cell	4 studies	31% ± 3%	Explore
acinar cell	4 studies	53% ± 20%	Explore
muscle cell	4 studies	45% ± 19%	Explore
germinal center B cell	4 studies	67% ± 28%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	74% ± 12%	Explore
luminal cell of prostate epithelium	4 studies	28% ± 7%	Explore
keratinocyte	4 studies	45% ± 12%	Explore
T-helper 1 cell	4 studies	76% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	69% ± 31%	Explore
hillock cell	3 studies	47% ± 22%	Explore
precursor cell	3 studies	83% ± 14%	Explore
pancreatic D cell	3 studies	55% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	63% ± 22%	Explore
podocyte	3 studies	67% ± 18%	Explore
neural crest cell	3 studies	73% ± 22%	Explore
retinal bipolar neuron	3 studies	39% ± 14%	Explore
renal principal cell	3 studies	56% ± 9%	Explore
thymocyte	3 studies	46% ± 28%	Explore
extravillous trophoblast	3 studies	57% ± 13%	Explore
placental villous trophoblast	3 studies	60% ± 13%	Explore
megakaryocyte	3 studies	65% ± 5%	Explore
neuroendocrine cell	3 studies	70% ± 24%	Explore
Schwann cell	3 studies	60% ± 31%	Explore
amacrine cell	3 studies	40% ± 3%	Explore
serous secreting cell	3 studies	54% ± 11%	Explore
tissue-resident macrophage	3 studies	49% ± 14%	Explore
intraepithelial lymphocyte	3 studies	55% ± 24%	Explore
rod bipolar cell	3 studies	33% ± 7%	Explore
myoepithelial cell	3 studies	64% ± 19%	Explore
inflammatory macrophage	3 studies	47% ± 7%	Explore
pancreatic ductal cell	3 studies	66% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	94% ± 6%	Explore
melanocyte	3 studies	40% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 15%	Explore
double-positive, alpha-beta thymocyte	3 studies	90% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	73% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	48% ± 20%	Explore
peripheral blood	19 studies	62% ± 17%	Explore
brain	16 studies	32% ± 15%	Explore
intestine	10 studies	51% ± 20%	Explore
eye	10 studies	37% ± 14%	Explore
kidney	9 studies	55% ± 19%	Explore
bone marrow	7 studies	43% ± 29%	Explore
liver	7 studies	47% ± 22%	Explore
lymph node	6 studies	73% ± 23%	Explore
pancreas	5 studies	54% ± 20%	Explore
heart	5 studies	23% ± 8%	Explore
uterus	5 studies	56% ± 20%	Explore
adipose	5 studies	35% ± 18%	Explore
placenta	4 studies	50% ± 21%	Explore
esophagus	4 studies	41% ± 30%	Explore
breast	4 studies	63% ± 6%	Explore
prostate	4 studies	36% ± 12%	Explore
adrenal gland	3 studies	52% ± 24%	Explore
thymus	3 studies	66% ± 32%	Explore
skin	3 studies	42% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	27189.52	258 / 258	100%	68.34	230 / 230
bladder	100%	20270.52	21 / 21	100%	62.75	504 / 504
esophagus	100%	18003.52	1445 / 1445	100%	49.83	183 / 183
intestine	100%	20444.92	966 / 966	100%	57.94	527 / 527
kidney	100%	26118.88	89 / 89	100%	65.95	901 / 901
liver	100%	11213.50	226 / 226	100%	48.52	406 / 406
lung	100%	23392.77	578 / 578	100%	63.09	1155 / 1155
ovary	100%	31053.14	180 / 180	100%	77.29	430 / 430
pancreas	100%	18358.12	328 / 328	100%	54.45	178 / 178
prostate	100%	18376.86	245 / 245	100%	61.28	502 / 502
skin	100%	26609.54	1809 / 1809	100%	56.83	472 / 472
stomach	100%	19676.99	359 / 359	100%	50.12	286 / 286
thymus	100%	25131.55	653 / 653	100%	80.96	605 / 605
uterus	100%	24763.14	170 / 170	100%	70.96	459 / 459
breast	100%	27031.96	459 / 459	100%	72.08	1115 / 1118
brain	99%	12297.24	2610 / 2642	100%	64.26	705 / 705
adipose	100%	28254.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	23749.02	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	80.73	80 / 80
lymph node	0%	0	0 / 0	100%	72.82	29 / 29
muscle	100%	16523.97	803 / 803	0%	0	0 / 0
peripheral blood	100%	26660.18	929 / 929	0%	0	0 / 0
spleen	100%	20436.45	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.40	45 / 45
ureter	0%	0	0 / 0	100%	36.60	1 / 1
heart	98%	13704.23	841 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045087	Biological process	innate immune response
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0051607	Biological process	defense response to virus
GO_0160049	Biological process	negative regulation of cGAS/STING signaling pathway
GO_0016071	Biological process	mRNA metabolic process
GO_0050687	Biological process	negative regulation of defense response to virus
GO_0140588	Biological process	chromatin looping
GO_0075522	Biological process	IRES-dependent viral translational initiation
GO_0039694	Biological process	viral RNA genome replication
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0140585	Molecular function	promoter-enhancer loop anchoring activity
GO_0003697	Molecular function	single-stranded DNA binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0003729	Molecular function	mRNA binding
GO_0106222	Molecular function	lncRNA binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PCBP2
Protein name	Poly(rC) binding protein 2 Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Alternative protein PCBP2
Synonyms
Description	FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC . Major cellular poly(rC)-binding protein . Binds also poly(rU) . Acts as a negative regulator of antiviral signaling . Negatively regulates cellular antiviral responses mediated by MAVS signaling . It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation . Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated . Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). .; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation . Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD . .
Accessions	ENST00000552819.5 [Q15366-8] F8VTZ0 ENST00000546463.6 [Q15366-3] ENST00000552296.6 [Q15366-6] L8E745 ENST00000548933.5 [Q15366-5] H3BRU6 H3BND9 ENST00000551104.5 F8W1G6 ENST00000547859.2 ENST00000546652.6 ENST00000553064.6 ENST00000562264.5 ENST00000552980.6 F8VRH0 F8VXH9 ENST00000359282.9 [Q15366-4] ENST00000550585.5 H3BSS4 H3BSP4 Q15366 ENST00000549863.5 F8VZX2 F8W0G4 ENST00000359462.9 [Q15366-2] ENST00000447282.5 [Q15366-5] ENST00000550520.6 ENST00000550192.5 ENST00000437231.5 [Q15366-7] ENST00000439930.7 [Q15366-1] ENST00000455667.7 [Q15366-7]

PCBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review