DOCK7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045200Biological processestablishment of neuroblast polarity
GO_0043547Biological processpositive regulation of GTPase activity
GO_0090630Biological processactivation of GTPase activity
GO_0031175Biological processneuron projection development
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0022027Biological processinterkinetic nuclear migration
GO_0007409Biological processaxonogenesis
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0050767Biological processregulation of neurogenesis
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0045178Cellular componentbasal part of cell
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0008180Cellular componentCOP9 signalosome
GO_0030426Cellular componentgrowth cone
GO_0030424Cellular componentaxon
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDOCK7
Protein nameDOCK7
Alternative protein DOCK7
DOCK7 protein
Dedicator of cytokinesis 7
Dedicator of cytokinesis protein 7
SynonymsKIAA1771
DescriptionFUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization . As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton . Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). .

AccessionsENST00000635827.1
A0A1B0GVW2
ENST00000634929.1
ENST00000634264.1 [Q96N67-3]
Q96N67
A0A0U1RQG7
A0A0U1RQJ5
ENST00000614472.5
A0A0U1RQT6
A0A2X0SSK2
L8EAM1
ENST00000634223.1
ENST00000637208.1
A0A0U1RRC1
ENST00000635123.1 [Q96N67-4]
ENST00000635088.1
ENST00000637255.1
ENST00000635253.2 [Q96N67-1]
ENST00000251157.10 [Q96N67-6]
ENST00000454575.6 [Q96N67-2]
A0A1B0GWE0
ENST00000340370.10 [Q96N67-5]
A0A0C4DGY6
A4FU72
ENST00000404627.3 [Q96N67-7]
ENST00000634652.1
A0A0U1RR97
A0A1B0GUE9
ENST00000464312.1