Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 20 studies | 55% ± 21% | |
glutamatergic neuron | 11 studies | 41% ± 26% | |
GABAergic neuron | 9 studies | 51% ± 20% | |
endothelial cell | 8 studies | 33% ± 16% | |
macrophage | 8 studies | 37% ± 13% | |
fibroblast | 8 studies | 23% ± 7% | |
neuron | 7 studies | 37% ± 18% | |
epithelial cell | 7 studies | 30% ± 12% | |
microglial cell | 7 studies | 27% ± 11% | |
oligodendrocyte precursor cell | 7 studies | 25% ± 5% | |
adipocyte | 7 studies | 26% ± 5% | |
interneuron | 6 studies | 54% ± 17% | |
pericyte | 6 studies | 27% ± 13% | |
myeloid cell | 4 studies | 23% ± 5% | |
retinal pigment epithelial cell | 4 studies | 53% ± 13% | |
Mueller cell | 4 studies | 36% ± 14% | |
amacrine cell | 4 studies | 39% ± 16% | |
smooth muscle cell | 4 studies | 23% ± 0% | |
basal cell | 4 studies | 32% ± 20% | |
GABAergic interneuron | 3 studies | 37% ± 8% | |
granule cell | 3 studies | 28% ± 7% | |
progenitor cell | 3 studies | 40% ± 9% | |
ciliated cell | 3 studies | 19% ± 3% | |
GABAergic amacrine cell | 3 studies | 41% ± 16% | |
glycinergic amacrine cell | 3 studies | 32% ± 10% | |
retina horizontal cell | 3 studies | 39% ± 17% | |
retinal ganglion cell | 3 studies | 46% ± 19% | |
retinal rod cell | 3 studies | 27% ± 4% | |
hepatocyte | 3 studies | 45% ± 29% | |
abnormal cell | 3 studies | 32% ± 11% | |
connective tissue cell | 3 studies | 22% ± 5% | |
ependymal cell | 3 studies | 62% ± 17% | |
alveolar macrophage | 3 studies | 31% ± 8% | |
endothelial cell of lymphatic vessel | 3 studies | 23% ± 4% | |
goblet cell | 3 studies | 25% ± 11% | |
transit amplifying cell | 3 studies | 37% ± 28% | |
oligodendrocyte | 3 studies | 31% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2256.25 | 2629 / 2642 | 99% | 11.89 | 695 / 705 |
esophagus | 100% | 2113.73 | 1442 / 1445 | 98% | 7.38 | 179 / 183 |
skin | 100% | 3500.89 | 1808 / 1809 | 97% | 14.16 | 457 / 472 |
breast | 100% | 2362.80 | 459 / 459 | 96% | 7.88 | 1068 / 1118 |
prostate | 100% | 2024.87 | 245 / 245 | 95% | 6.76 | 478 / 502 |
stomach | 100% | 1994.23 | 359 / 359 | 94% | 5.64 | 270 / 286 |
intestine | 100% | 2496.90 | 966 / 966 | 94% | 4.92 | 497 / 527 |
lung | 99% | 1481.38 | 573 / 578 | 95% | 5.16 | 1099 / 1155 |
ovary | 100% | 3428.27 | 180 / 180 | 93% | 4.29 | 398 / 430 |
bladder | 100% | 2680.29 | 21 / 21 | 92% | 4.97 | 462 / 504 |
pancreas | 95% | 864.70 | 311 / 328 | 96% | 4.85 | 170 / 178 |
uterus | 100% | 3149.71 | 170 / 170 | 88% | 4.53 | 402 / 459 |
thymus | 100% | 1660.67 | 651 / 653 | 83% | 3.44 | 503 / 605 |
kidney | 100% | 1525.72 | 89 / 89 | 80% | 4.16 | 724 / 901 |
adrenal gland | 100% | 1370.09 | 257 / 258 | 69% | 3.44 | 158 / 230 |
liver | 94% | 859.12 | 213 / 226 | 56% | 2.30 | 229 / 406 |
adipose | 100% | 2378.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3158.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1178.15 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 4.89 | 40 / 45 |
eye | 0% | 0 | 0 / 0 | 89% | 7.33 | 71 / 80 |
heart | 87% | 927.66 | 751 / 861 | 0% | 0 | 0 / 0 |
muscle | 72% | 504.35 | 582 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 41% | 1.21 | 12 / 29 |
peripheral blood | 19% | 569.77 | 175 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045200 | Biological process | establishment of neuroblast polarity |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0090630 | Biological process | activation of GTPase activity |
GO_0031175 | Biological process | neuron projection development |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_0022027 | Biological process | interkinetic nuclear migration |
GO_0007409 | Biological process | axonogenesis |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0050767 | Biological process | regulation of neurogenesis |
GO_1904754 | Biological process | positive regulation of vascular associated smooth muscle cell migration |
GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
GO_0045178 | Cellular component | basal part of cell |
GO_0043005 | Cellular component | neuron projection |
GO_0005925 | Cellular component | focal adhesion |
GO_0008180 | Cellular component | COP9 signalosome |
GO_0030426 | Cellular component | growth cone |
GO_0030424 | Cellular component | axon |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DOCK7 |
Protein name | DOCK7 Alternative protein DOCK7 DOCK7 protein Dedicator of cytokinesis 7 Dedicator of cytokinesis protein 7 |
Synonyms | KIAA1771 |
Description | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization . As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton . Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). . |
Accessions | ENST00000635827.1 A0A1B0GVW2 ENST00000634929.1 ENST00000634264.1 [Q96N67-3] Q96N67 A0A0U1RQG7 A0A0U1RQJ5 ENST00000614472.5 A0A0U1RQT6 A0A2X0SSK2 L8EAM1 ENST00000634223.1 ENST00000637208.1 A0A0U1RRC1 ENST00000635123.1 [Q96N67-4] ENST00000635088.1 ENST00000637255.1 ENST00000635253.2 [Q96N67-1] ENST00000251157.10 [Q96N67-6] ENST00000454575.6 [Q96N67-2] A0A1B0GWE0 ENST00000340370.10 [Q96N67-5] A0A0C4DGY6 A4FU72 ENST00000404627.3 [Q96N67-7] ENST00000634652.1 A0A0U1RR97 A0A1B0GUE9 ENST00000464312.1 |