Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 38 studies | 41% ± 16% | |
memory B cell | 18 studies | 38% ± 9% | |
naive B cell | 18 studies | 32% ± 9% | |
microglial cell | 18 studies | 74% ± 18% | |
macrophage | 17 studies | 45% ± 23% | |
fibroblast | 16 studies | 40% ± 18% | |
pericyte | 13 studies | 30% ± 18% | |
astrocyte | 12 studies | 53% ± 22% | |
adipocyte | 11 studies | 51% ± 22% | |
endothelial cell | 8 studies | 25% ± 7% | |
myeloid cell | 8 studies | 36% ± 21% | |
epithelial cell of proximal tubule | 7 studies | 24% ± 7% | |
kidney loop of Henle epithelial cell | 7 studies | 46% ± 9% | |
basal cell | 7 studies | 35% ± 16% | |
type I pneumocyte | 7 studies | 41% ± 14% | |
kidney distal convoluted tubule epithelial cell | 6 studies | 45% ± 15% | |
GABAergic neuron | 6 studies | 36% ± 14% | |
retina horizontal cell | 6 studies | 53% ± 20% | |
cardiac muscle cell | 6 studies | 52% ± 17% | |
ciliated cell | 6 studies | 40% ± 17% | |
smooth muscle cell | 6 studies | 33% ± 11% | |
dendritic cell | 5 studies | 28% ± 8% | |
monocyte | 5 studies | 41% ± 5% | |
type II pneumocyte | 5 studies | 49% ± 9% | |
classical monocyte | 4 studies | 19% ± 4% | |
neuron | 4 studies | 31% ± 16% | |
Mueller cell | 4 studies | 36% ± 11% | |
glutamatergic neuron | 4 studies | 43% ± 14% | |
hepatic stellate cell | 3 studies | 41% ± 12% | |
epithelial cell | 3 studies | 26% ± 1% | |
alveolar macrophage | 3 studies | 39% ± 7% | |
club cell | 3 studies | 34% ± 5% | |
myofibroblast cell | 3 studies | 44% ± 21% | |
respiratory goblet cell | 3 studies | 30% ± 10% | |
Schwann cell | 3 studies | 51% ± 20% | |
plasmacytoid dendritic cell | 3 studies | 27% ± 8% | |
renal alpha-intercalated cell | 3 studies | 25% ± 5% | |
renal principal cell | 3 studies | 28% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 3920.92 | 89 / 89 | 98% | 20.31 | 883 / 901 |
pancreas | 100% | 974.98 | 327 / 328 | 85% | 5.43 | 152 / 178 |
lung | 100% | 1552.14 | 578 / 578 | 82% | 5.12 | 944 / 1155 |
brain | 87% | 751.81 | 2303 / 2642 | 93% | 6.37 | 657 / 705 |
skin | 100% | 1657.96 | 1800 / 1809 | 75% | 6.66 | 356 / 472 |
thymus | 100% | 2026.59 | 651 / 653 | 74% | 6.40 | 450 / 605 |
breast | 100% | 1291.01 | 457 / 459 | 68% | 3.00 | 759 / 1118 |
esophagus | 95% | 830.21 | 1375 / 1445 | 69% | 3.40 | 127 / 183 |
stomach | 100% | 1346.91 | 359 / 359 | 49% | 2.59 | 139 / 286 |
uterus | 98% | 940.90 | 167 / 170 | 47% | 2.85 | 214 / 459 |
intestine | 97% | 934.29 | 933 / 966 | 35% | 1.61 | 182 / 527 |
bladder | 100% | 1187.81 | 21 / 21 | 31% | 1.28 | 154 / 504 |
prostate | 90% | 556.41 | 221 / 245 | 29% | 0.80 | 144 / 502 |
ovary | 87% | 519.27 | 156 / 180 | 15% | 0.53 | 65 / 430 |
liver | 65% | 243.19 | 146 / 226 | 37% | 1.59 | 150 / 406 |
adipose | 100% | 1699.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 1989.85 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1741.40 | 1332 / 1335 | 0% | 0 | 0 / 0 |
heart | 93% | 1013.93 | 803 / 861 | 0% | 0 | 0 / 0 |
adrenal gland | 35% | 126.90 | 91 / 258 | 54% | 3.19 | 125 / 230 |
lymph node | 0% | 0 | 0 / 0 | 86% | 7.57 | 25 / 29 |
peripheral blood | 79% | 724.91 | 735 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 4.79 | 34 / 45 |
eye | 0% | 0 | 0 / 0 | 75% | 7.66 | 60 / 80 |
muscle | 68% | 366.11 | 544 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007165 | Biological process | signal transduction |
GO_0001525 | Biological process | angiogenesis |
GO_1900028 | Biological process | negative regulation of ruffle assembly |
GO_0030154 | Biological process | cell differentiation |
GO_0035021 | Biological process | negative regulation of Rac protein signal transduction |
GO_0035313 | Biological process | wound healing, spreading of epidermal cells |
GO_0090630 | Biological process | activation of GTPase activity |
GO_0042995 | Cellular component | cell projection |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005912 | Cellular component | adherens junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0005925 | Cellular component | focal adhesion |
GO_0005515 | Molecular function | protein binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | ARHGAP24 |
Protein name | Rho GTPase activating protein 24 ARHGAP24 Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) |
Synonyms | FILGAP |
Description | FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. . |
Accessions | D6RCP5 ENST00000503995.5 [Q8N264-4] Q8N264 ENST00000395184.6 [Q8N264-1] D6RHH1 D6RBC2 ENST00000514229.5 ENST00000512201.5 ENST00000264343.4 [Q8N264-2] ENST00000509300.5 A0A2X0SFU2 ENST00000395183.6 [Q8N264-3] |