ARHGAP24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0001525Biological processangiogenesis
GO_1900028Biological processnegative regulation of ruffle assembly
GO_0030154Biological processcell differentiation
GO_0035021Biological processnegative regulation of Rac protein signal transduction
GO_0035313Biological processwound healing, spreading of epidermal cells
GO_0090630Biological processactivation of GTPase activity
GO_0042995Cellular componentcell projection
GO_0005856Cellular componentcytoskeleton
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameARHGAP24
Protein nameRho GTPase activating protein 24
ARHGAP24
Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
SynonymsFILGAP
DescriptionFUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. .

AccessionsD6RCP5
ENST00000503995.5 [Q8N264-4]
Q8N264
ENST00000395184.6 [Q8N264-1]
D6RHH1
D6RBC2
ENST00000514229.5
ENST00000512201.5
ENST00000264343.4 [Q8N264-2]
ENST00000509300.5
A0A2X0SFU2
ENST00000395183.6 [Q8N264-3]