NHERF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0065003Biological processprotein-containing complex assembly
GO_0016324Cellular componentapical plasma membrane
GO_0012505Cellular componentendomembrane system
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0005634Cellular componentnucleus
GO_0031800Molecular functiontype 3 metabotropic glutamate receptor binding
GO_0045296Molecular functioncadherin binding
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0019902Molecular functionphosphatase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0031799Molecular functiontype 2 metabotropic glutamate receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameNHERF2
Protein nameNa(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
NHERF family PDZ scaffold protein 2
SLC9A3R2 protein
SynonymsSLC9A3R2
DescriptionFUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 . May also act as scaffold protein in the nucleus. .

AccessionsENST00000424542.7 [Q15599-1]
ENST00000565855.5
ENST00000432365.6 [Q15599-2]
H3BQS0
ENST00000563587.5
Q15599
H3BMF5
ENST00000567504.5
ENST00000561844.5
Q6NTG0
H3BN50
ENST00000566198.1 [Q15599-3]
H3BUQ9