ARHGEF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055059Biological processasymmetric neuroblast division
GO_0045087Biological processinnate immune response
GO_2001224Biological processpositive regulation of neuron migration
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0006886Biological processintracellular protein transport
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0060546Biological processnegative regulation of necroptotic process
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0007015Biological processactin filament organization
GO_1902219Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0071474Biological processcellular hyperosmotic response
GO_0000902Biological processcell morphogenesis
GO_0071225Biological processcellular response to muramyl dipeptide
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0042127Biological processregulation of cell population proliferation
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032587Cellular componentruffle membrane
GO_0005856Cellular componentcytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0031982Cellular componentvesicle
GO_0005819Cellular componentspindle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0008270Molecular functionzinc ion binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARHGEF2
Protein nameRho/Rac guanine nucleotide exchange factor 2
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
SynonymsLFP40
KIAA0651
DescriptionFUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation . Involved in the migration of precerebellar neurons (By similarity). .

AccessionsENST00000495070.2
V9GYM8
ENST00000471589.5
V9GYF0
ENST00000696600.1
ENST00000497907.5
V9GZ14
ENST00000313695.11 [Q92974-3]
ENST00000470541.6
V9GY94
ENST00000470874.5
A0A5F9ZI21
A0A8Q3SIN5
ENST00000361247.9 [Q92974-1]
Q92974
V9GZ58
V9GYG5
ENST00000462460.6
ENST00000696601.1
ENST00000673475.1
ENST00000313667.8 [Q92974-2]
ENST00000423422.6
A0A1Y8EN19
A0A8Q3SIV8
V9GYF5
ENST00000609707.1