SVIL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007519Biological processskeletal muscle tissue development
GO_0051016Biological processbarbed-end actin filament capping
GO_0008154Biological processactin polymerization or depolymerization
GO_0051014Biological processactin filament severing
GO_0032467Biological processpositive regulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0043034Cellular componentcostamere
GO_0036449Cellular componentmicrotubule minus-end
GO_0002102Cellular componentpodosome
GO_0005925Cellular componentfocal adhesion
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0032154Cellular componentcleavage furrow
GO_0005634Cellular componentnucleus
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSVIL
Protein nameAlternative protein SVIL
Supervillin
Supervillin (Archvillin) (p205/p250)
SVIL protein
Synonyms
DescriptionFUNCTION: [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation . Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function . .; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). .

AccessionsENST00000375400.7 [O95425-2]
ENST00000674475.1
Q569J5
L0R8G3
ENST00000375398.6 [O95425-4]
A0A6I8PIX7
A0A0J9YWY6
O95425
A0A6I8PL75
ENST00000674242.1
ENST00000355867.9 [O95425-1]
ENST00000632315.1