IRF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	21 studies	20% ± 4%	Explore
B cell	18 studies	21% ± 4%	Explore
naive B cell	16 studies	21% ± 5%	Explore
endothelial cell	16 studies	25% ± 7%	Explore
regulatory T cell	16 studies	20% ± 5%	Explore
non-classical monocyte	14 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 5%	Explore
macrophage	12 studies	25% ± 7%	Explore
T cell	10 studies	17% ± 2%	Explore
monocyte	10 studies	20% ± 3%	Explore
astrocyte	10 studies	31% ± 15%	Explore
oligodendrocyte	10 studies	28% ± 10%	Explore
classical monocyte	9 studies	21% ± 5%	Explore
microglial cell	9 studies	25% ± 10%	Explore
gamma-delta T cell	9 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	22% ± 6%	Explore
ciliated cell	8 studies	27% ± 9%	Explore
memory B cell	8 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	20% ± 2%	Explore
mature NK T cell	7 studies	18% ± 1%	Explore
fibroblast	7 studies	19% ± 3%	Explore
basal cell	6 studies	28% ± 12%	Explore
CD4-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	23% ± 6%	Explore
epithelial cell	6 studies	40% ± 16%	Explore
oligodendrocyte precursor cell	6 studies	30% ± 13%	Explore
mucosal invariant T cell	6 studies	20% ± 3%	Explore
plasma cell	5 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
conventional dendritic cell	5 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	17% ± 2%	Explore
leukocyte	4 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
exhausted T cell	4 studies	26% ± 6%	Explore
myeloid cell	4 studies	28% ± 7%	Explore
capillary endothelial cell	4 studies	19% ± 3%	Explore
immature B cell	4 studies	25% ± 5%	Explore
cardiac muscle cell	4 studies	21% ± 4%	Explore
dendritic cell	4 studies	28% ± 10%	Explore
goblet cell	4 studies	23% ± 8%	Explore
mononuclear phagocyte	3 studies	22% ± 6%	Explore
lymphocyte	3 studies	28% ± 2%	Explore
T follicular helper cell	3 studies	18% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
myofibroblast cell	3 studies	16% ± 1%	Explore
type I pneumocyte	3 studies	17% ± 1%	Explore
GABAergic neuron	3 studies	37% ± 7%	Explore
glutamatergic neuron	3 studies	38% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
innate lymphoid cell	3 studies	21% ± 2%	Explore
pericyte	3 studies	17% ± 2%	Explore
respiratory goblet cell	3 studies	22% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	20% ± 3%	Explore
brain	7 studies	30% ± 13%	Explore
lung	5 studies	24% ± 7%	Explore
liver	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2081.10	1445 / 1445	100%	49.53	183 / 183
ovary	100%	2181.68	180 / 180	100%	39.30	430 / 430
prostate	100%	2175.82	245 / 245	100%	43.20	502 / 502
stomach	100%	1884.33	359 / 359	100%	46.12	286 / 286
breast	100%	2427.23	459 / 459	100%	51.63	1117 / 1118
lung	100%	2725.67	578 / 578	100%	48.34	1153 / 1155
kidney	100%	1418.92	89 / 89	100%	41.10	898 / 901
bladder	100%	2601.86	21 / 21	100%	45.30	502 / 504
thymus	100%	1880.98	653 / 653	100%	46.84	602 / 605
intestine	100%	2382.38	966 / 966	99%	45.50	524 / 527
brain	100%	1064.08	2629 / 2642	100%	39.58	704 / 705
adrenal gland	100%	3088.64	258 / 258	99%	32.17	228 / 230
uterus	100%	2310.62	170 / 170	99%	47.83	455 / 459
skin	100%	1995.15	1808 / 1809	98%	41.25	464 / 472
liver	100%	1605.23	226 / 226	96%	26.34	391 / 406
pancreas	97%	881.57	319 / 328	99%	45.75	176 / 178
adipose	100%	2573.10	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2325.69	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	76.87	29 / 29
spleen	100%	4089.81	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.67	45 / 45
ureter	0%	0	0 / 0	100%	25.90	1 / 1
muscle	100%	1496.50	802 / 803	0%	0	0 / 0
peripheral blood	100%	5170.95	927 / 929	0%	0	0 / 0
heart	99%	1189.68	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	23.02	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002376	Biological process	immune system process
GO_0008283	Biological process	cell population proliferation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0051607	Biological process	defense response to virus
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IRF2
Protein name	Interferon regulatory factor Interferon regulatory factor 2 (IRF-2) Alternative protein IRF2 Interferon regulatory factor 2
Synonyms
Description	FUNCTION: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. .
Accessions	ENST00000696849.1 [P14316-1] ENST00000507523.5 ENST00000502750.2 ENST00000696853.1 [P14316-2] ENST00000696851.1 [P14316-1] K4DIA5 P14316 ENST00000510814.6 [P14316-1] ENST00000505067.6 ENST00000393593.8 [P14316-1] ENST00000696843.1 [P14316-1] ENST00000504340.2 [P14316-1] ENST00000696840.1 [P14316-1] L8E7Q0 A0A8Q3SIZ2 D6R9N5 ENST00000696846.1 [P14316-1] ENST00000696850.1 ENST00000506230.5 ENST00000696844.1 ENST00000696852.1 A0A8Q3SIV4 A0A8Q3SIZ8 H0Y956 D6RED1 ENST00000696841.1 [P14316-1] ENST00000696848.1 [P14316-2] ENST00000696842.1 K4DIA4 ENST00000509274.1 D6RB08 ENST00000510814.5 A0A8Q3SJ30 ENST00000696845.1 [P14316-1]

IRF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review