RHOB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	47% ± 20%	Explore
fibroblast	38 studies	40% ± 17%	Explore
macrophage	36 studies	47% ± 19%	Explore
pericyte	32 studies	62% ± 21%	Explore
smooth muscle cell	30 studies	54% ± 22%	Explore
classical monocyte	23 studies	37% ± 18%	Explore
non-classical monocyte	22 studies	58% ± 17%	Explore
B cell	20 studies	33% ± 15%	Explore
endothelial cell of lymphatic vessel	20 studies	41% ± 14%	Explore
conventional dendritic cell	20 studies	36% ± 15%	Explore
astrocyte	18 studies	35% ± 15%	Explore
monocyte	17 studies	41% ± 20%	Explore
connective tissue cell	17 studies	41% ± 20%	Explore
ciliated cell	16 studies	40% ± 20%	Explore
endothelial cell of artery	15 studies	62% ± 22%	Explore
capillary endothelial cell	15 studies	51% ± 20%	Explore
natural killer cell	14 studies	32% ± 12%	Explore
basal cell	14 studies	40% ± 19%	Explore
epithelial cell	14 studies	52% ± 22%	Explore
myofibroblast cell	14 studies	55% ± 16%	Explore
endothelial cell of vascular tree	14 studies	39% ± 19%	Explore
dendritic cell	13 studies	40% ± 16%	Explore
plasma cell	13 studies	31% ± 13%	Explore
vein endothelial cell	12 studies	42% ± 16%	Explore
memory B cell	12 studies	32% ± 12%	Explore
oligodendrocyte	10 studies	27% ± 8%	Explore
mesothelial cell	10 studies	53% ± 24%	Explore
myeloid cell	10 studies	38% ± 17%	Explore
goblet cell	9 studies	33% ± 13%	Explore
naive B cell	9 studies	30% ± 10%	Explore
type I pneumocyte	8 studies	38% ± 17%	Explore
type II pneumocyte	8 studies	44% ± 20%	Explore
secretory cell	8 studies	40% ± 19%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
abnormal cell	8 studies	48% ± 24%	Explore
T cell	7 studies	22% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	35% ± 17%	Explore
leukocyte	7 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
alveolar macrophage	6 studies	55% ± 23%	Explore
club cell	6 studies	42% ± 21%	Explore
mononuclear phagocyte	6 studies	32% ± 17%	Explore
plasmablast	6 studies	34% ± 13%	Explore
neuron	6 studies	44% ± 22%	Explore
glial cell	6 studies	52% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	28% ± 11%	Explore
adipocyte	6 studies	28% ± 7%	Explore
gamma-delta T cell	6 studies	28% ± 9%	Explore
neutrophil	5 studies	24% ± 6%	Explore
mature NK T cell	5 studies	27% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	42% ± 12%	Explore
microglial cell	5 studies	30% ± 18%	Explore
precursor B cell	5 studies	28% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	28% ± 12%	Explore
hepatocyte	5 studies	51% ± 25%	Explore
mast cell	4 studies	20% ± 3%	Explore
respiratory goblet cell	4 studies	34% ± 16%	Explore
glomerular endothelial cell	4 studies	80% ± 5%	Explore
progenitor cell	4 studies	39% ± 11%	Explore
renal alpha-intercalated cell	4 studies	37% ± 13%	Explore
kidney loop of Henle epithelial cell	4 studies	45% ± 12%	Explore
enterocyte	4 studies	28% ± 8%	Explore
Schwann cell	4 studies	60% ± 28%	Explore
immature B cell	4 studies	32% ± 9%	Explore
pro-B cell	4 studies	26% ± 4%	Explore
retinal pigment epithelial cell	4 studies	42% ± 19%	Explore
adventitial cell	4 studies	49% ± 4%	Explore
intermediate monocyte	4 studies	54% ± 21%	Explore
regulatory T cell	4 studies	22% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	56% ± 21%	Explore
oligodendrocyte precursor cell	4 studies	35% ± 11%	Explore
innate lymphoid cell	4 studies	28% ± 10%	Explore
squamous epithelial cell	3 studies	41% ± 23%	Explore
pancreatic A cell	3 studies	37% ± 4%	Explore
hematopoietic precursor cell	3 studies	20% ± 6%	Explore
renal principal cell	3 studies	43% ± 12%	Explore
neuroendocrine cell	3 studies	48% ± 14%	Explore
tissue-resident macrophage	3 studies	44% ± 17%	Explore
Mueller cell	3 studies	55% ± 5%	Explore
endothelial cell of sinusoid	3 studies	41% ± 21%	Explore
muscle cell	3 studies	58% ± 17%	Explore
GABAergic neuron	3 studies	21% ± 3%	Explore
glutamatergic neuron	3 studies	26% ± 3%	Explore
pancreatic ductal cell	3 studies	46% ± 12%	Explore
enteroendocrine cell	3 studies	54% ± 11%	Explore
mucus secreting cell	3 studies	28% ± 18%	Explore
T follicular helper cell	3 studies	24% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 9%	Explore
melanocyte	3 studies	29% ± 9%	Explore
IgA plasma cell	3 studies	19% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	43% ± 18%	Explore
IgG plasma cell	3 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	35% ± 13%	Explore
intestine	9 studies	35% ± 19%	Explore
brain	9 studies	27% ± 10%	Explore
kidney	9 studies	36% ± 14%	Explore
peripheral blood	7 studies	22% ± 9%	Explore
eye	6 studies	26% ± 11%	Explore
uterus	6 studies	41% ± 12%	Explore
liver	5 studies	32% ± 11%	Explore
lymph node	4 studies	39% ± 31%	Explore
breast	4 studies	40% ± 11%	Explore
pancreas	3 studies	31% ± 8%	Explore
placenta	3 studies	22% ± 3%	Explore
ovary	3 studies	31% ± 13%	Explore
adipose	3 studies	34% ± 5%	Explore
adrenal gland	3 studies	33% ± 9%	Explore
esophagus	3 studies	35% ± 18%	Explore
skin	3 studies	31% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	44595.74	258 / 258	97%	606.20	223 / 230
prostate	98%	40602.18	241 / 245	98%	558.18	493 / 502
breast	100%	53135.78	457 / 459	96%	741.56	1068 / 1118
brain	93%	20342.81	2450 / 2642	100%	1015.03	703 / 705
bladder	100%	56523.29	21 / 21	91%	314.71	457 / 504
lung	98%	42492.88	566 / 578	90%	367.01	1039 / 1155
liver	89%	24684.40	202 / 226	97%	564.63	392 / 406
stomach	90%	40970.18	322 / 359	90%	344.11	257 / 286
intestine	87%	49321.67	844 / 966	91%	307.38	481 / 527
uterus	98%	44543.10	167 / 170	79%	309.77	364 / 459
thymus	88%	20288.88	575 / 653	88%	332.44	534 / 605
kidney	84%	16955.07	75 / 89	92%	897.06	829 / 901
esophagus	83%	47954.51	1196 / 1445	91%	359.82	166 / 183
ovary	98%	47170.79	177 / 180	69%	169.99	295 / 430
skin	74%	28572.83	1346 / 1809	72%	202.23	342 / 472
pancreas	27%	3841.07	88 / 328	96%	409.36	170 / 178
ureter	0%	0	0 / 0	100%	111.06	1 / 1
adipose	100%	62462.51	1203 / 1204	0%	0	0 / 0
blood vessel	100%	125570.05	1332 / 1335	0%	0	0 / 0
heart	88%	21633.38	761 / 861	0%	0	0 / 0
muscle	78%	22928.10	630 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	69%	154.35	31 / 45
spleen	66%	11084.77	158 / 241	0%	0	0 / 0
peripheral blood	37%	15754.43	348 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	20%	27.80	16 / 80
lymph node	0%	0	0 / 0	7%	9.37	2 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_0045786	Biological process	negative regulation of cell cycle
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0007165	Biological process	signal transduction
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0006886	Biological process	intracellular protein transport
GO_0000281	Biological process	mitotic cytokinesis
GO_0007155	Biological process	cell adhesion
GO_0061154	Biological process	endothelial tube morphogenesis
GO_0030154	Biological process	cell differentiation
GO_0030334	Biological process	regulation of cell migration
GO_0008333	Biological process	endosome to lysosome transport
GO_0007015	Biological process	actin filament organization
GO_0006915	Biological process	apoptotic process
GO_0007266	Biological process	Rho protein signal transduction
GO_0030336	Biological process	negative regulation of cell migration
GO_0071479	Biological process	cellular response to ionizing radiation
GO_0099159	Biological process	regulation of modification of postsynaptic structure
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0031902	Cellular component	late endosome membrane
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0010008	Cellular component	endosome membrane
GO_0032154	Cellular component	cleavage furrow
GO_0005634	Cellular component	nucleus
GO_0019003	Molecular function	GDP binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RHOB
Protein name	Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Synonyms	ARHB ARH6
Description	FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. .
Accessions	ENST00000272233.6 P62745

RHOB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review