Insufficient scRNA-seq data for expression of PRUNE1 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1519.24 | 459 / 459 | 100% | 76.24 | 1118 / 1118 |
| ovary | 100% | 1685.51 | 180 / 180 | 100% | 59.28 | 430 / 430 |
| prostate | 100% | 1504.83 | 245 / 245 | 100% | 39.11 | 502 / 502 |
| esophagus | 100% | 1415.85 | 1444 / 1445 | 100% | 35.94 | 183 / 183 |
| uterus | 100% | 2004.57 | 170 / 170 | 100% | 42.56 | 458 / 459 |
| lung | 100% | 1221.46 | 576 / 578 | 100% | 45.48 | 1155 / 1155 |
| stomach | 100% | 1126.81 | 359 / 359 | 100% | 31.90 | 285 / 286 |
| intestine | 100% | 1676.41 | 966 / 966 | 100% | 31.60 | 525 / 527 |
| bladder | 100% | 1753.29 | 21 / 21 | 100% | 38.43 | 502 / 504 |
| thymus | 100% | 3185.51 | 653 / 653 | 100% | 50.50 | 602 / 605 |
| skin | 100% | 1195.95 | 1809 / 1809 | 99% | 38.29 | 469 / 472 |
| brain | 99% | 1045.39 | 2608 / 2642 | 100% | 29.41 | 705 / 705 |
| pancreas | 99% | 734.38 | 324 / 328 | 99% | 30.34 | 177 / 178 |
| kidney | 100% | 1607.45 | 89 / 89 | 98% | 34.41 | 880 / 901 |
| liver | 97% | 862.61 | 219 / 226 | 98% | 28.15 | 398 / 406 |
| adrenal gland | 98% | 1166.16 | 254 / 258 | 93% | 23.52 | 215 / 230 |
| adipose | 100% | 1250.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1589.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 24.43 | 29 / 29 |
| muscle | 100% | 2068.86 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1341.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 36.30 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 33.99 | 1 / 1 |
| heart | 98% | 2204.70 | 843 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 23.98 | 77 / 80 |
| peripheral blood | 94% | 936.56 | 876 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0031113 | Biological process | regulation of microtubule polymerization |
| GO_0005829 | Cellular component | cytosol |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0016791 | Molecular function | phosphatase activity |
| GO_0004309 | Molecular function | exopolyphosphatase activity |
| GO_0004427 | Molecular function | inorganic diphosphate phosphatase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0015631 | Molecular function | tubulin binding |
| Gene name | PRUNE1 |
| Protein name | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) Prune exopolyphosphatase 1 |
| Synonyms | PRUNE |
| Description | FUNCTION: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis . Involved in the regulation of microtubule polymerization . . |
| Accessions | ENST00000650332.1 Q5SZF2 Q5SZG1 ENST00000271620.8 [Q86TP1-1] ENST00000368934.1 [Q86TP1-5] ENST00000368935.1 [Q86TP1-6] A0A3B3ITN0 Q86TP1 ENST00000450884.5 ENST00000368937.5 [Q86TP1-5] ENST00000368936.5 [Q86TP1-3] ENST00000431193.5 |
