Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 47 studies | 41% ± 15% | |
pericyte | 36 studies | 53% ± 27% | |
fibroblast | 32 studies | 40% ± 19% | |
smooth muscle cell | 20 studies | 41% ± 22% | |
mast cell | 15 studies | 33% ± 13% | |
capillary endothelial cell | 14 studies | 32% ± 10% | |
oligodendrocyte | 13 studies | 62% ± 14% | |
type I pneumocyte | 12 studies | 61% ± 18% | |
type II pneumocyte | 12 studies | 56% ± 20% | |
astrocyte | 12 studies | 47% ± 21% | |
oligodendrocyte precursor cell | 12 studies | 40% ± 16% | |
vein endothelial cell | 12 studies | 32% ± 10% | |
adipocyte | 11 studies | 80% ± 14% | |
endothelial cell of vascular tree | 11 studies | 33% ± 15% | |
endothelial cell of lymphatic vessel | 9 studies | 37% ± 14% | |
myofibroblast cell | 8 studies | 29% ± 13% | |
connective tissue cell | 8 studies | 31% ± 16% | |
glutamatergic neuron | 8 studies | 35% ± 18% | |
GABAergic neuron | 7 studies | 42% ± 20% | |
endothelial cell of artery | 7 studies | 24% ± 7% | |
epithelial cell | 6 studies | 32% ± 12% | |
cardiac muscle cell | 6 studies | 55% ± 20% | |
neuron | 5 studies | 46% ± 17% | |
retinal ganglion cell | 5 studies | 35% ± 11% | |
endothelial cell of sinusoid | 4 studies | 34% ± 16% | |
glomerular endothelial cell | 4 studies | 37% ± 6% | |
glial cell | 4 studies | 38% ± 20% | |
hepatocyte | 4 studies | 60% ± 19% | |
club cell | 4 studies | 29% ± 5% | |
microglial cell | 4 studies | 52% ± 25% | |
hepatic stellate cell | 3 studies | 56% ± 25% | |
abnormal cell | 3 studies | 50% ± 19% | |
GABAergic interneuron | 3 studies | 21% ± 5% | |
endocardial cell | 3 studies | 50% ± 12% | |
retina horizontal cell | 3 studies | 22% ± 3% | |
muscle cell | 3 studies | 50% ± 27% | |
adventitial cell | 3 studies | 42% ± 14% | |
chondrocyte | 3 studies | 35% ± 18% | |
ciliated cell | 3 studies | 17% ± 1% | |
Schwann cell | 3 studies | 62% ± 18% | |
interneuron | 3 studies | 52% ± 10% | |
mesothelial cell | 3 studies | 54% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 99% | 2973.00 | 255 / 258 | 96% | 18.77 | 220 / 230 |
breast | 100% | 10128.58 | 459 / 459 | 94% | 12.77 | 1047 / 1118 |
thymus | 100% | 5485.89 | 650 / 653 | 89% | 20.95 | 537 / 605 |
kidney | 98% | 3294.39 | 87 / 89 | 87% | 15.67 | 785 / 901 |
skin | 85% | 4791.41 | 1544 / 1809 | 97% | 32.05 | 458 / 472 |
brain | 85% | 2921.74 | 2256 / 2642 | 97% | 11.35 | 681 / 705 |
lung | 100% | 14284.97 | 578 / 578 | 82% | 13.46 | 942 / 1155 |
liver | 95% | 2706.61 | 215 / 226 | 83% | 6.74 | 335 / 406 |
stomach | 83% | 3943.99 | 298 / 359 | 79% | 7.75 | 226 / 286 |
intestine | 93% | 5247.65 | 902 / 966 | 68% | 5.07 | 357 / 527 |
bladder | 95% | 3480.00 | 20 / 21 | 60% | 5.28 | 304 / 504 |
prostate | 89% | 2221.30 | 218 / 245 | 62% | 4.03 | 311 / 502 |
esophagus | 75% | 3809.49 | 1077 / 1445 | 73% | 6.33 | 134 / 183 |
uterus | 99% | 4165.74 | 168 / 170 | 41% | 4.35 | 190 / 459 |
pancreas | 40% | 654.67 | 130 / 328 | 93% | 10.63 | 165 / 178 |
ovary | 82% | 2206.63 | 147 / 180 | 32% | 1.85 | 136 / 430 |
adipose | 100% | 14019.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.35 | 1 / 1 |
blood vessel | 100% | 6457.10 | 1332 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3896.65 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 100% | 3869.36 | 857 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 14.56 | 76 / 80 |
muscle | 52% | 947.33 | 421 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 36% | 1.87 | 16 / 45 |
lymph node | 0% | 0 | 0 / 0 | 21% | 0.90 | 6 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035024 | Biological process | negative regulation of Rho protein signal transduction |
GO_0006919 | Biological process | activation of cysteine-type endopeptidase activity involved in apoptotic process |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0021575 | Biological process | hindbrain morphogenesis |
GO_0030900 | Biological process | forebrain development |
GO_0007165 | Biological process | signal transduction |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0051895 | Biological process | negative regulation of focal adhesion assembly |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0051497 | Biological process | negative regulation of stress fiber assembly |
GO_0035023 | Biological process | regulation of Rho protein signal transduction |
GO_0001843 | Biological process | neural tube closure |
GO_0048041 | Biological process | focal adhesion assembly |
GO_0006915 | Biological process | apoptotic process |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0008360 | Biological process | regulation of cell shape |
GO_0003007 | Biological process | heart morphogenesis |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_1900119 | Biological process | positive regulation of execution phase of apoptosis |
GO_0035307 | Biological process | positive regulation of protein dephosphorylation |
GO_0032587 | Cellular component | ruffle membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0030864 | Cellular component | cortical actin cytoskeleton |
GO_0005925 | Cellular component | focal adhesion |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005901 | Cellular component | caveola |
GO_0005634 | Cellular component | nucleus |
GO_0008289 | Molecular function | lipid binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0042169 | Molecular function | SH2 domain binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DLC1 |
Protein name | DLC1 Rho GTPase activating protein Rho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StAR-related lipid transfer protein 12) Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) Deleted in liver cancer 1 variant 2 |
Synonyms | STARD12 KIAA1723 ARHGAP7 |
Description | FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 . The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation . . |
Accessions | ENST00000631382.1 ENST00000517868.2 E5RI70 Q45XF9 ENST00000358919.6 [Q96QB1-1] A0A0J9YWS8 R4GMP5 Q96QB1 ENST00000316609.9 [Q96QB1-3] A0A2X0SYX6 ENST00000511869.1 [Q96QB1-5] ENST00000276297.9 [Q96QB1-2] ENST00000512044.6 [Q96QB1-6] ENST00000520226.5 [Q96QB1-4] ENST00000503161.6 |