DLC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0021575Biological processhindbrain morphogenesis
GO_0030900Biological processforebrain development
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0001843Biological processneural tube closure
GO_0048041Biological processfocal adhesion assembly
GO_0006915Biological processapoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_0008360Biological processregulation of cell shape
GO_0003007Biological processheart morphogenesis
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0032587Cellular componentruffle membrane
GO_0045121Cellular componentmembrane raft
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0005925Cellular componentfocal adhesion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0008289Molecular functionlipid binding
GO_0005096Molecular functionGTPase activator activity
GO_0042169Molecular functionSH2 domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDLC1
Protein nameDLC1 Rho GTPase activating protein
Rho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StAR-related lipid transfer protein 12)
Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)
Deleted in liver cancer 1 variant 2
SynonymsSTARD12
KIAA1723
ARHGAP7
DescriptionFUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 . The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation . .

AccessionsENST00000631382.1
ENST00000517868.2
E5RI70
Q45XF9
ENST00000358919.6 [Q96QB1-1]
A0A0J9YWS8
R4GMP5
Q96QB1
ENST00000316609.9 [Q96QB1-3]
A0A2X0SYX6
ENST00000511869.1 [Q96QB1-5]
ENST00000276297.9 [Q96QB1-2]
ENST00000512044.6 [Q96QB1-6]
ENST00000520226.5 [Q96QB1-4]
ENST00000503161.6