EZR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	48 studies	62% ± 18%	Explore
natural killer cell	36 studies	33% ± 13%	Explore
CD8-positive, alpha-beta T cell	36 studies	42% ± 14%	Explore
T cell	34 studies	41% ± 17%	Explore
CD4-positive, alpha-beta T cell	33 studies	40% ± 16%	Explore
macrophage	31 studies	29% ± 13%	Explore
regulatory T cell	28 studies	50% ± 16%	Explore
conventional dendritic cell	27 studies	39% ± 18%	Explore
non-classical monocyte	23 studies	36% ± 14%	Explore
basal cell	23 studies	49% ± 17%	Explore
epithelial cell	23 studies	62% ± 16%	Explore
pericyte	22 studies	36% ± 23%	Explore
ciliated cell	21 studies	81% ± 15%	Explore
classical monocyte	21 studies	33% ± 12%	Explore
plasma cell	20 studies	48% ± 13%	Explore
memory B cell	20 studies	72% ± 15%	Explore
naive B cell	20 studies	60% ± 17%	Explore
plasmacytoid dendritic cell	20 studies	43% ± 16%	Explore
dendritic cell	19 studies	42% ± 22%	Explore
gamma-delta T cell	18 studies	45% ± 18%	Explore
mature NK T cell	18 studies	36% ± 13%	Explore
smooth muscle cell	17 studies	32% ± 16%	Explore
monocyte	16 studies	31% ± 11%	Explore
fibroblast	16 studies	26% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	29% ± 9%	Explore
mucosal invariant T cell	15 studies	46% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 15%	Explore
astrocyte	15 studies	38% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	31% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	14 studies	49% ± 16%	Explore
mesothelial cell	14 studies	65% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	46% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	47% ± 16%	Explore
endothelial cell	13 studies	28% ± 10%	Explore
type I pneumocyte	12 studies	63% ± 17%	Explore
type II pneumocyte	12 studies	51% ± 17%	Explore
plasmablast	12 studies	53% ± 24%	Explore
club cell	12 studies	60% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 12%	Explore
secretory cell	11 studies	66% ± 11%	Explore
myeloid cell	11 studies	33% ± 15%	Explore
mast cell	10 studies	27% ± 8%	Explore
goblet cell	10 studies	47% ± 18%	Explore
epithelial cell of proximal tubule	9 studies	34% ± 13%	Explore
abnormal cell	9 studies	43% ± 16%	Explore
innate lymphoid cell	9 studies	35% ± 14%	Explore
respiratory goblet cell	8 studies	74% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	52% ± 14%	Explore
leukocyte	8 studies	48% ± 13%	Explore
enterocyte	8 studies	46% ± 20%	Explore
CD4-positive helper T cell	7 studies	42% ± 21%	Explore
renal alpha-intercalated cell	7 studies	49% ± 12%	Explore
progenitor cell	7 studies	31% ± 14%	Explore
precursor B cell	7 studies	60% ± 9%	Explore
T follicular helper cell	7 studies	41% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	35% ± 13%	Explore
ionocyte	6 studies	51% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	57% ± 11%	Explore
mononuclear phagocyte	6 studies	38% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	38% ± 18%	Explore
immature B cell	6 studies	60% ± 7%	Explore
IgA plasma cell	6 studies	37% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	55% ± 17%	Explore
alveolar macrophage	5 studies	21% ± 2%	Explore
hematopoietic precursor cell	5 studies	31% ± 10%	Explore
exhausted T cell	5 studies	52% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	39% ± 14%	Explore
lymphocyte	5 studies	33% ± 16%	Explore
pro-B cell	5 studies	53% ± 7%	Explore
retinal pigment epithelial cell	5 studies	64% ± 12%	Explore
double negative thymocyte	5 studies	53% ± 13%	Explore
IgG plasma cell	5 studies	31% ± 11%	Explore
keratinocyte	5 studies	55% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	39% ± 10%	Explore
deuterosomal cell	4 studies	70% ± 5%	Explore
squamous epithelial cell	4 studies	73% ± 10%	Explore
platelet	4 studies	22% ± 7%	Explore
pancreatic A cell	4 studies	48% ± 16%	Explore
transit amplifying cell	4 studies	36% ± 21%	Explore
renal principal cell	4 studies	43% ± 17%	Explore
brush cell	4 studies	28% ± 12%	Explore
germinal center B cell	4 studies	62% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 5%	Explore
granulocyte	4 studies	30% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	49% ± 11%	Explore
connective tissue cell	4 studies	23% ± 8%	Explore
mucus secreting cell	4 studies	44% ± 20%	Explore
T-helper 17 cell	4 studies	45% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	41% ± 11%	Explore
duct epithelial cell	3 studies	53% ± 12%	Explore
hillock cell	3 studies	52% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	55% ± 11%	Explore
podocyte	3 studies	54% ± 7%	Explore
parietal epithelial cell	3 studies	40% ± 16%	Explore
microglial cell	3 studies	18% ± 3%	Explore
extravillous trophoblast	3 studies	91% ± 1%	Explore
placental villous trophoblast	3 studies	91% ± 6%	Explore
hematopoietic stem cell	3 studies	18% ± 2%	Explore
neuroendocrine cell	3 studies	30% ± 7%	Explore
glial cell	3 studies	21% ± 4%	Explore
tissue-resident macrophage	3 studies	31% ± 16%	Explore
erythroblast	3 studies	34% ± 16%	Explore
myoepithelial cell	3 studies	49% ± 28%	Explore
pancreatic ductal cell	3 studies	68% ± 16%	Explore
ependymal cell	3 studies	48% ± 16%	Explore
enteroendocrine cell	3 studies	33% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	60% ± 12%	Explore
T-helper 1 cell	3 studies	50% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	48% ± 3%	Explore
erythrocyte	3 studies	41% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	38% ± 14%	Explore
peripheral blood	19 studies	38% ± 14%	Explore
intestine	12 studies	27% ± 8%	Explore
kidney	10 studies	29% ± 11%	Explore
prostate	5 studies	43% ± 17%	Explore
lymph node	5 studies	44% ± 8%	Explore
pancreas	4 studies	38% ± 15%	Explore
placenta	4 studies	56% ± 28%	Explore
bone marrow	4 studies	31% ± 12%	Explore
uterus	4 studies	38% ± 20%	Explore
breast	4 studies	38% ± 3%	Explore
brain	4 studies	28% ± 4%	Explore
liver	4 studies	27% ± 8%	Explore
esophagus	3 studies	46% ± 15%	Explore
thymus	3 studies	35% ± 14%	Explore
skin	3 studies	39% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	13782.67	21 / 21	100%	486.81	502 / 504
lung	100%	24527.02	577 / 578	100%	511.83	1152 / 1155
thymus	100%	17201.78	653 / 653	100%	476.12	602 / 605
esophagus	99%	21179.77	1437 / 1445	100%	463.42	183 / 183
prostate	100%	10931.09	245 / 245	99%	378.40	499 / 502
kidney	100%	16308.19	89 / 89	99%	749.10	893 / 901
intestine	98%	13964.60	945 / 966	100%	473.65	525 / 527
stomach	97%	21011.01	350 / 359	99%	424.90	284 / 286
pancreas	94%	7046.70	308 / 328	99%	634.80	176 / 178
breast	91%	5406.06	418 / 459	99%	458.84	1108 / 1118
ovary	93%	6379.01	167 / 180	97%	242.65	416 / 430
uterus	78%	4373.02	132 / 170	98%	499.77	452 / 459
brain	78%	6987.55	2052 / 2642	96%	314.73	679 / 705
skin	89%	19394.75	1608 / 1809	84%	202.42	395 / 472
adrenal gland	100%	27071.32	258 / 258	59%	142.46	135 / 230
lymph node	0%	0	0 / 0	100%	716.75	29 / 29
spleen	100%	11019.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	481.43	45 / 45
ureter	0%	0	0 / 0	100%	166.36	1 / 1
liver	62%	3859.34	139 / 226	37%	62.50	150 / 406
heart	93%	11370.31	798 / 861	0%	0	0 / 0
adipose	91%	8162.71	1098 / 1204	0%	0	0 / 0
blood vessel	87%	5020.20	1165 / 1335	0%	0	0 / 0
peripheral blood	86%	11768.05	796 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	71%	128.53	57 / 80
muscle	60%	3550.81	482 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045198	Biological process	establishment of epithelial cell apical/basal polarity
GO_0032532	Biological process	regulation of microvillus length
GO_0031623	Biological process	receptor internalization
GO_1901222	Biological process	regulation of non-canonical NF-kappaB signal transduction
GO_0072659	Biological process	protein localization to plasma membrane
GO_0072697	Biological process	protein localization to cell cortex
GO_0030036	Biological process	actin cytoskeleton organization
GO_0071320	Biological process	cellular response to cAMP
GO_0046847	Biological process	filopodium assembly
GO_0051660	Biological process	establishment of centrosome localization
GO_2000643	Biological process	positive regulation of early endosome to late endosome transport
GO_0010628	Biological process	positive regulation of gene expression
GO_0010737	Biological process	protein kinase A signaling
GO_1902966	Biological process	positive regulation of protein localization to early endosome
GO_0030033	Biological process	microvillus assembly
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_0003376	Biological process	sphingosine-1-phosphate receptor signaling pathway
GO_0022612	Biological process	gland morphogenesis
GO_0061028	Biological process	establishment of endothelial barrier
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0043622	Biological process	cortical microtubule organization
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0051017	Biological process	actin filament bundle assembly
GO_1902896	Biological process	terminal web assembly
GO_0001951	Biological process	intestinal D-glucose absorption
GO_0031503	Biological process	protein-containing complex localization
GO_0022614	Biological process	membrane to membrane docking
GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_0098974	Biological process	postsynaptic actin cytoskeleton organization
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_1902115	Biological process	regulation of organelle assembly
GO_0008360	Biological process	regulation of cell shape
GO_0030953	Biological process	astral microtubule organization
GO_0008361	Biological process	regulation of cell size
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_1903753	Biological process	negative regulation of p38MAPK cascade
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0001772	Cellular component	immunological synapse
GO_0044853	Cellular component	plasma membrane raft
GO_0071944	Cellular component	cell periphery
GO_0005768	Cellular component	endosome
GO_0001931	Cellular component	uropod
GO_0016323	Cellular component	basolateral plasma membrane
GO_0001726	Cellular component	ruffle
GO_0070062	Cellular component	extracellular exosome
GO_0001650	Cellular component	fibrillar center
GO_0030175	Cellular component	filopodium
GO_0030863	Cellular component	cortical cytoskeleton
GO_0015629	Cellular component	actin cytoskeleton
GO_0005912	Cellular component	adherens junction
GO_0005902	Cellular component	microvillus
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031528	Cellular component	microvillus membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005884	Cellular component	actin filament
GO_0005737	Cellular component	cytoplasm
GO_0036064	Cellular component	ciliary basal body
GO_0045177	Cellular component	apical part of cell
GO_0032587	Cellular component	ruffle membrane
GO_0005903	Cellular component	brush border
GO_0016324	Cellular component	apical plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0031982	Cellular component	vesicle
GO_0042802	Molecular function	identical protein binding
GO_0034236	Molecular function	protein kinase A catalytic subunit binding
GO_0051117	Molecular function	ATPase binding
GO_0051018	Molecular function	protein kinase A binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0003779	Molecular function	actin binding
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0019904	Molecular function	protein domain specific binding
GO_0051015	Molecular function	actin filament binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0045296	Molecular function	cadherin binding
GO_0008017	Molecular function	microtubule binding
GO_0044548	Molecular function	S100 protein binding
GO_0097718	Molecular function	disordered domain specific binding

IV. Literature review

[source]

Gene name	EZR
Protein name	Ezrin (Cytovillin) (Villin-2) (p81)
Synonyms	VIL2
Description	FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. .
Accessions	Q6NUR7 ENST00000337147.11 ENST00000367075.4 P15311

EZR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review