LRP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	45% ± 18%	Explore
macrophage	38 studies	37% ± 13%	Explore
classical monocyte	23 studies	36% ± 13%	Explore
astrocyte	19 studies	39% ± 17%	Explore
non-classical monocyte	17 studies	27% ± 9%	Explore
monocyte	16 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	15 studies	55% ± 20%	Explore
pericyte	15 studies	23% ± 11%	Explore
smooth muscle cell	13 studies	25% ± 9%	Explore
connective tissue cell	13 studies	37% ± 14%	Explore
microglial cell	12 studies	37% ± 15%	Explore
myeloid cell	11 studies	35% ± 13%	Explore
myofibroblast cell	11 studies	29% ± 12%	Explore
adipocyte	11 studies	53% ± 17%	Explore
alveolar macrophage	8 studies	49% ± 17%	Explore
endothelial cell	8 studies	38% ± 15%	Explore
GABAergic neuron	7 studies	39% ± 17%	Explore
glutamatergic neuron	7 studies	37% ± 21%	Explore
basal cell	6 studies	32% ± 21%	Explore
conventional dendritic cell	6 studies	23% ± 5%	Explore
interneuron	6 studies	34% ± 18%	Explore
abnormal cell	5 studies	48% ± 14%	Explore
neuron	5 studies	29% ± 8%	Explore
adventitial cell	5 studies	59% ± 6%	Explore
dendritic cell	5 studies	25% ± 8%	Explore
mesothelial cell	5 studies	21% ± 8%	Explore
mononuclear phagocyte	5 studies	26% ± 10%	Explore
Mueller cell	5 studies	23% ± 5%	Explore
hepatocyte	5 studies	39% ± 17%	Explore
granule cell	4 studies	24% ± 7%	Explore
epithelial cell	4 studies	36% ± 19%	Explore
intermediate monocyte	4 studies	40% ± 13%	Explore
glial cell	3 studies	23% ± 8%	Explore
placental villous trophoblast	3 studies	25% ± 8%	Explore
retinal pigment epithelial cell	3 studies	30% ± 13%	Explore
tissue-resident macrophage	3 studies	32% ± 12%	Explore
muscle cell	3 studies	20% ± 4%	Explore
chondrocyte	3 studies	29% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	31% ± 14%	Explore
lung	10 studies	21% ± 5%	Explore
adipose	5 studies	41% ± 22%	Explore
intestine	4 studies	24% ± 8%	Explore
heart	4 studies	19% ± 3%	Explore
peripheral blood	3 studies	21% ± 1%	Explore
uterus	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	34421.03	1438 / 1445	98%	91.11	180 / 183
liver	99%	35020.40	223 / 226	99%	71.99	401 / 406
intestine	100%	33051.51	964 / 966	96%	65.08	508 / 527
lung	100%	52772.87	576 / 578	95%	66.49	1096 / 1155
breast	100%	64732.08	458 / 459	95%	71.08	1057 / 1118
brain	93%	24388.74	2463 / 2642	100%	167.44	704 / 705
skin	99%	59049.67	1788 / 1809	93%	58.44	440 / 472
uterus	100%	59007.20	170 / 170	89%	59.04	409 / 459
prostate	98%	28369.19	240 / 245	88%	42.20	444 / 502
bladder	100%	41303.14	21 / 21	85%	43.79	430 / 504
ovary	100%	76667.94	180 / 180	84%	42.91	362 / 430
thymus	99%	30288.65	646 / 653	80%	30.69	482 / 605
stomach	69%	18603.28	249 / 359	97%	76.11	276 / 286
adrenal gland	86%	15519.04	222 / 258	72%	31.90	165 / 230
kidney	39%	7295.73	35 / 89	85%	47.70	763 / 901
pancreas	18%	2300.29	60 / 328	96%	95.95	171 / 178
adipose	100%	84604.28	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	14.78	1 / 1
blood vessel	100%	76741.52	1334 / 1335	0%	0	0 / 0
heart	96%	29084.98	827 / 861	0%	0	0 / 0
spleen	95%	18401.45	230 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	60.21	42 / 45
eye	0%	0	0 / 0	89%	43.13	71 / 80
lymph node	0%	0	0 / 0	55%	18.25	16 / 29
muscle	32%	4694.74	259 / 803	0%	0	0 / 0
peripheral blood	11%	1446.75	103 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031623	Biological process	receptor internalization
GO_0014912	Biological process	negative regulation of smooth muscle cell migration
GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0010629	Biological process	negative regulation of gene expression
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0032374	Biological process	regulation of cholesterol transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0007041	Biological process	lysosomal transport
GO_0007167	Biological process	enzyme-linked receptor protein signaling pathway
GO_0032092	Biological process	positive regulation of protein binding
GO_0045807	Biological process	positive regulation of endocytosis
GO_0010715	Biological process	regulation of extracellular matrix disassembly
GO_0002265	Biological process	astrocyte activation involved in immune response
GO_0097242	Biological process	amyloid-beta clearance
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0001523	Biological process	retinoid metabolic process
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0043277	Biological process	apoptotic cell clearance
GO_0150093	Biological process	amyloid-beta clearance by transcytosis
GO_1900223	Biological process	positive regulation of amyloid-beta clearance
GO_0150094	Biological process	amyloid-beta clearance by cellular catabolic process
GO_0035909	Biological process	aorta morphogenesis
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_1904300	Biological process	positive regulation of transcytosis
GO_0006909	Biological process	phagocytosis
GO_0032370	Biological process	positive regulation of lipid transport
GO_0045056	Biological process	transcytosis
GO_0042953	Biological process	lipoprotein transport
GO_1905049	Biological process	negative regulation of metallopeptidase activity
GO_0006629	Biological process	lipid metabolic process
GO_1904646	Biological process	cellular response to amyloid-beta
GO_1905167	Biological process	positive regulation of lysosomal protein catabolic process
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0032429	Biological process	regulation of phospholipase A2 activity
GO_2000587	Biological process	negative regulation of platelet-derived growth factor receptor-beta signaling pathway
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005815	Cellular component	microtubule organizing center
GO_0005794	Cellular component	Golgi apparatus
GO_0005925	Cellular component	focal adhesion
GO_0098797	Cellular component	plasma membrane protein complex
GO_0005905	Cellular component	clathrin-coated pit
GO_0005765	Cellular component	lysosomal membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0030226	Molecular function	apolipoprotein receptor activity
GO_0038023	Molecular function	signaling receptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0032050	Molecular function	clathrin heavy chain binding
GO_0038024	Molecular function	cargo receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0005044	Molecular function	scavenger receptor activity
GO_0034185	Molecular function	apolipoprotein binding
GO_0016964	Molecular function	alpha-2 macroglobulin receptor activity
GO_0005041	Molecular function	low-density lipoprotein particle receptor activity
GO_0003723	Molecular function	RNA binding
GO_0043395	Molecular function	heparan sulfate proteoglycan binding
GO_0005509	Molecular function	calcium ion binding
GO_0070325	Molecular function	lipoprotein particle receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LRP1
Protein name	LDL receptor related protein 1 Alternative protein LRP1 LDL receptor related protein 1 (LRP1 protein) Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Synonyms	A2MR APR
Description	FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells . Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor . Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread . May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission . .; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. .
Accessions	ENST00000338962.8 [Q07954-2] H0YJ88 Q7Z7K9 ENST00000555124.1 ENST00000554174.1 ENST00000553277.5 ENST00000554118.1 Q6PJ72 L0R6J6 H0YJI8 Q07954 ENST00000243077.8 [Q07954-1]

LRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review