Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2490.50 | 1445 / 1445 | 100% | 27.72 | 183 / 183 |
| lung | 100% | 3029.77 | 578 / 578 | 100% | 27.41 | 1155 / 1155 |
| prostate | 100% | 4237.61 | 245 / 245 | 100% | 45.63 | 502 / 502 |
| brain | 100% | 3345.08 | 2640 / 2642 | 100% | 40.00 | 705 / 705 |
| breast | 100% | 3564.08 | 459 / 459 | 100% | 31.01 | 1117 / 1118 |
| thymus | 100% | 3809.37 | 653 / 653 | 100% | 35.06 | 602 / 605 |
| uterus | 100% | 3571.14 | 170 / 170 | 99% | 24.99 | 455 / 459 |
| kidney | 100% | 2432.48 | 89 / 89 | 99% | 28.10 | 891 / 901 |
| pancreas | 100% | 2037.49 | 328 / 328 | 98% | 23.88 | 175 / 178 |
| stomach | 100% | 2232.11 | 359 / 359 | 98% | 20.60 | 281 / 286 |
| ovary | 100% | 3987.88 | 180 / 180 | 98% | 15.75 | 422 / 430 |
| bladder | 100% | 3096.38 | 21 / 21 | 98% | 21.72 | 493 / 504 |
| intestine | 100% | 3021.80 | 966 / 966 | 98% | 22.10 | 515 / 527 |
| liver | 100% | 2003.38 | 226 / 226 | 97% | 15.41 | 395 / 406 |
| adrenal gland | 100% | 3338.17 | 258 / 258 | 97% | 36.95 | 223 / 230 |
| skin | 100% | 2863.19 | 1807 / 1809 | 95% | 34.92 | 450 / 472 |
| adipose | 100% | 4051.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3467.81 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 41.16 | 29 / 29 |
| muscle | 100% | 1936.92 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2984.42 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 24.03 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.02 | 1 / 1 |
| heart | 97% | 1801.76 | 831 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 86% | 15.33 | 69 / 80 |
| peripheral blood | 76% | 1890.29 | 702 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035646 | Biological process | endosome to melanosome transport |
| GO_0060271 | Biological process | cilium assembly |
| GO_0046907 | Biological process | intracellular transport |
| GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
| GO_0031175 | Biological process | neuron projection development |
| GO_0008089 | Biological process | anterograde axonal transport |
| GO_0061025 | Biological process | membrane fusion |
| GO_0033299 | Biological process | secretion of lysosomal enzymes |
| GO_0021542 | Biological process | dentate gyrus development |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0001822 | Biological process | kidney development |
| GO_0006541 | Biological process | glutamine metabolic process |
| GO_0046085 | Biological process | adenosine metabolic process |
| GO_0046034 | Biological process | ATP metabolic process |
| GO_0048872 | Biological process | homeostasis of number of cells |
| GO_0007596 | Biological process | blood coagulation |
| GO_0014823 | Biological process | response to activity |
| GO_0006605 | Biological process | protein targeting |
| GO_0032438 | Biological process | melanosome organization |
| GO_0032402 | Biological process | melanosome transport |
| GO_0016081 | Biological process | synaptic vesicle docking |
| GO_0051017 | Biological process | actin filament bundle assembly |
| GO_0048490 | Biological process | anterograde synaptic vesicle transport |
| GO_0006536 | Biological process | glutamate metabolic process |
| GO_0033484 | Biological process | intracellular nitric oxide homeostasis |
| GO_1905144 | Biological process | response to acetylcholine |
| GO_0030318 | Biological process | melanocyte differentiation |
| GO_0032816 | Biological process | positive regulation of natural killer cell activation |
| GO_0003016 | Biological process | respiratory system process |
| GO_0002936 | Biological process | bradykinin biosynthetic process |
| GO_0003158 | Biological process | endothelium development |
| GO_0050942 | Biological process | positive regulation of pigment cell differentiation |
| GO_0042745 | Biological process | circadian sleep/wake cycle |
| GO_0007613 | Biological process | memory |
| GO_0006644 | Biological process | phospholipid metabolic process |
| GO_0010467 | Biological process | gene expression |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0042311 | Biological process | vasodilation |
| GO_0021854 | Biological process | hypothalamus development |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0071806 | Biological process | protein transmembrane transport |
| GO_0001726 | Cellular component | ruffle |
| GO_0098793 | Cellular component | presynapse |
| GO_0043227 | Cellular component | membrane-bounded organelle |
| GO_0031941 | Cellular component | filamentous actin |
| GO_1990742 | Cellular component | microvesicle |
| GO_0031201 | Cellular component | SNARE complex |
| GO_0044291 | Cellular component | cell-cell contact zone |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0070938 | Cellular component | contractile ring |
| GO_0001725 | Cellular component | stress fiber |
| GO_0005829 | Cellular component | cytosol |
| GO_0031083 | Cellular component | BLOC-1 complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030133 | Cellular component | transport vesicle |
| GO_0005768 | Cellular component | endosome |
| GO_1904115 | Cellular component | axon cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0019905 | Molecular function | syntaxin binding |
| Gene name | BLOC1S6 |
| Protein name | Biogenesis of lysosomal organelles complex 1 subunit 6 Biogenesis of lysosomal organelles complex 1 subunit 6 (HCG2001986, isoform CRA_g) Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) Biogenesis of lysosomal organelles complex 1 subunit 6 (HCG2001986, isoform CRA_c) Biogenesis of lysosome-related organelles complex 1 subunit 6 Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) |
| Synonyms | hCG_2001986 PA PLDN |
| Description | FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. . FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. . |
| Accessions | ENST00000564765.1 ENST00000567461.5 H3BNE3 H3BST1 ENST00000565216.5 H3BRA4 ENST00000566801.5 H3BPR6 ENST00000565409.5 A0A5F9ZHH0 H3BR42 H3BML5 ENST00000564310.2 H3BN13 Q9UL45 ENST00000220531.9 [Q9UL45-1] ENST00000568816.5 ENST00000567523.5 [Q9UL45-2] H3BMT8 H3BN73 ENST00000565323.6 ENST00000562384.5 ENST00000569076.5 ENST00000672455.1 ENST00000568597.5 ENST00000568963.5 |
