ARL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034260Biological processnegative regulation of GTPase activity
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0006110Biological processregulation of glycolytic process
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0007098Biological processcentrosome cycle
GO_0006457Biological processprotein folding
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0070830Biological processbicellular tight junction assembly
GO_1903715Biological processregulation of aerobic respiration
GO_0031113Biological processregulation of microtubule polymerization
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005759Cellular componentmitochondrial matrix
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameARL2
Protein nameADP-ribosylation factor-like protein 2
Synonyms
DescriptionFUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle . Also regulates mitochondrial integrity and function . .

AccessionsENST00000246747.9 [P36404-1]
ENST00000529384.5 [P36404-1]
P36404
ENST00000533729.1 [P36404-2]