REXO2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	29 studies	31% ± 13%	Explore
endothelial cell of lymphatic vessel	18 studies	49% ± 16%	Explore
smooth muscle cell	18 studies	23% ± 9%	Explore
endothelial cell	18 studies	29% ± 11%	Explore
regulatory T cell	17 studies	25% ± 11%	Explore
pericyte	15 studies	22% ± 10%	Explore
basal cell	14 studies	29% ± 16%	Explore
connective tissue cell	13 studies	30% ± 10%	Explore
epithelial cell	13 studies	36% ± 15%	Explore
plasma cell	10 studies	29% ± 13%	Explore
ciliated cell	10 studies	36% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	10 studies	24% ± 9%	Explore
endothelial cell of artery	9 studies	21% ± 4%	Explore
myofibroblast cell	9 studies	22% ± 4%	Explore
type I pneumocyte	8 studies	31% ± 10%	Explore
plasmablast	8 studies	32% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 5%	Explore
endothelial cell of vascular tree	8 studies	22% ± 4%	Explore
secretory cell	7 studies	29% ± 16%	Explore
epithelial cell of proximal tubule	6 studies	32% ± 7%	Explore
club cell	6 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	22% ± 7%	Explore
kidney loop of Henle epithelial cell	5 studies	30% ± 7%	Explore
natural killer cell	5 studies	18% ± 2%	Explore
erythroblast	5 studies	53% ± 8%	Explore
vein endothelial cell	5 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
erythrocyte	5 studies	46% ± 28%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	26% ± 9%	Explore
deuterosomal cell	4 studies	21% ± 5%	Explore
conventional dendritic cell	4 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
mesothelial cell	4 studies	36% ± 14%	Explore
abnormal cell	4 studies	29% ± 7%	Explore
precursor B cell	4 studies	27% ± 7%	Explore
adventitial cell	4 studies	42% ± 11%	Explore
type II pneumocyte	4 studies	28% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 7%	Explore
oligodendrocyte	4 studies	17% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
goblet cell	4 studies	27% ± 6%	Explore
hematopoietic precursor cell	3 studies	28% ± 11%	Explore
squamous epithelial cell	3 studies	37% ± 25%	Explore
pancreatic A cell	3 studies	42% ± 7%	Explore
type B pancreatic cell	3 studies	34% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 1%	Explore
extravillous trophoblast	3 studies	24% ± 4%	Explore
placental villous trophoblast	3 studies	39% ± 8%	Explore
pro-B cell	3 studies	27% ± 4%	Explore
serous secreting cell	3 studies	21% ± 3%	Explore
capillary endothelial cell	3 studies	19% ± 2%	Explore
oligodendrocyte precursor cell	3 studies	17% ± 2%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
keratinocyte	3 studies	20% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	18% ± 2%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	28% ± 15%	Explore
intestine	4 studies	20% ± 8%	Explore
peripheral blood	4 studies	18% ± 3%	Explore
kidney	4 studies	23% ± 5%	Explore
uterus	4 studies	29% ± 11%	Explore
breast	4 studies	19% ± 1%	Explore
brain	4 studies	22% ± 7%	Explore
pancreas	3 studies	38% ± 6%	Explore
bone marrow	3 studies	17% ± 0%	Explore
liver	3 studies	36% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3612.46	1445 / 1445	100%	21.83	183 / 183
intestine	100%	3499.35	966 / 966	100%	31.65	527 / 527
ovary	100%	3401.14	180 / 180	100%	28.60	430 / 430
stomach	100%	3103.09	359 / 359	100%	27.48	286 / 286
uterus	100%	3786.94	170 / 170	100%	30.16	459 / 459
bladder	100%	3573.43	21 / 21	100%	33.31	503 / 504
breast	100%	2735.89	459 / 459	100%	24.84	1115 / 1118
lung	100%	2708.29	576 / 578	100%	27.87	1155 / 1155
prostate	100%	3638.59	244 / 245	100%	74.67	501 / 502
kidney	100%	2956.90	89 / 89	99%	25.24	895 / 901
thymus	100%	1855.63	651 / 653	100%	19.39	602 / 605
skin	100%	4201.15	1808 / 1809	99%	25.05	465 / 472
pancreas	99%	1297.09	324 / 328	99%	29.96	177 / 178
adrenal gland	100%	3386.52	258 / 258	97%	17.97	222 / 230
liver	94%	1160.29	212 / 226	99%	15.52	401 / 406
brain	90%	839.35	2386 / 2642	100%	16.14	703 / 705
adipose	100%	2869.69	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3891.68	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.15	29 / 29
spleen	100%	2459.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	16.40	45 / 45
ureter	0%	0	0 / 0	100%	11.11	1 / 1
muscle	98%	1641.95	790 / 803	0%	0	0 / 0
heart	97%	3895.24	837 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	15.67	75 / 80
peripheral blood	31%	254.20	292 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006139	Biological process	nucleobase-containing compound metabolic process
GO_0006259	Biological process	DNA metabolic process
GO_0009117	Biological process	nucleotide metabolic process
GO_0005730	Cellular component	nucleolus
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0005737	Cellular component	cytoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_0005925	Cellular component	focal adhesion
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0000175	Molecular function	3'-5'-RNA exonuclease activity
GO_0008296	Molecular function	3'-5'-DNA exonuclease activity
GO_0003676	Molecular function	nucleic acid binding
GO_0000287	Molecular function	magnesium ion binding
GO_0008408	Molecular function	3'-5' exonuclease activity

IV. Literature review

[source]

Gene name	REXO2
Protein name	RNA exonuclease 2 REXO2 protein (RNA exonuclease 2) Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)
Synonyms	SMFN SFN CGI-114
Description	FUNCTION: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides . Binds and degrades longer oligonucleotides with a lower affinity . Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing . Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome . Essential for embryonic development (By similarity). .; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. .
Accessions	F5GYG5 Q9BTR4 H0YGR4 ENST00000543131.5 ENST00000539119.5 F5H7P1 ENST00000544827.5 H0YF66 H0YG37 F5H6P8 ENST00000546316.5 ENST00000265881.10 [Q9Y3B8-1] ENST00000538198.5 ENST00000539275.5 Q9Y3B8 ENST00000541703.5 H0YG54 ENST00000544196.5 F5H784 ENST00000539754.5

REXO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review