RAB10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045200Biological processestablishment of neuroblast polarity
GO_0071786Biological processendoplasmic reticulum tubular network organization
GO_0097051Biological processestablishment of protein localization to endoplasmic reticulum membrane
GO_0072659Biological processprotein localization to plasma membrane
GO_0032869Biological processcellular response to insulin stimulus
GO_1903361Biological processprotein localization to basolateral plasma membrane
GO_0007409Biological processaxonogenesis
GO_0045055Biological processregulated exocytosis
GO_0016192Biological processvesicle-mediated transport
GO_0090150Biological processestablishment of protein localization to membrane
GO_0016197Biological processendosomal transport
GO_0006887Biological processexocytosis
GO_0006893Biological processGolgi to plasma membrane transport
GO_0019882Biological processantigen processing and presentation
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_0098609Biological processcell-cell adhesion
GO_0030859Biological processpolarized epithelial cell differentiation
GO_0009306Biological processprotein secretion
GO_0070382Cellular componentexocytic vesicle
GO_0030667Cellular componentsecretory granule membrane
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0055037Cellular componentrecycling endosome
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005802Cellular componenttrans-Golgi network
GO_0099503Cellular componentsecretory vesicle
GO_0000139Cellular componentGolgi membrane
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0032593Cellular componentinsulin-responsive compartment
GO_0000145Cellular componentexocyst
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0019003Molecular functionGDP binding
GO_0003925Molecular functionG protein activity
GO_0031489Molecular functionmyosin V binding
GO_0005525Molecular functionGTP binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAB10
Protein nameRas-related protein Rab-10
Ras-related protein Rab-10 (EC 3.6.5.2)
GTP-binding protein RAB10
Uncharacterized protein RAB10
Synonyms
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane . Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane . In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane . May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion . Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis . When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis . Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route . .; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. .

AccessionsP61026
Q53T70
Q9UL28
Q53SX4
ENST00000264710.5