I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 71% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 71% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 39% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 25431.72 | 226 / 226 | 97% | 313.76 | 394 / 406 |
| pancreas | 75% | 63.48 | 247 / 328 | 87% | 7.80 | 155 / 178 |
| intestine | 60% | 93.24 | 583 / 966 | 95% | 16.84 | 500 / 527 |
| lung | 74% | 52.97 | 427 / 578 | 77% | 5.94 | 894 / 1155 |
| kidney | 83% | 214.02 | 74 / 89 | 62% | 5.17 | 563 / 901 |
| brain | 75% | 207.72 | 1976 / 2642 | 62% | 3.61 | 435 / 705 |
| esophagus | 40% | 216.06 | 583 / 1445 | 93% | 9.95 | 170 / 183 |
| skin | 79% | 208.02 | 1428 / 1809 | 54% | 4.03 | 253 / 472 |
| breast | 45% | 37.27 | 205 / 459 | 83% | 7.84 | 932 / 1118 |
| prostate | 65% | 57.62 | 159 / 245 | 52% | 2.62 | 262 / 502 |
| bladder | 33% | 24.86 | 7 / 21 | 74% | 8.85 | 373 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.29 | 45 / 45 |
| stomach | 16% | 9.86 | 56 / 359 | 84% | 10.81 | 240 / 286 |
| peripheral blood | 98% | 219.09 | 908 / 929 | 0% | 0 | 0 / 0 |
| uterus | 10% | 8.44 | 17 / 170 | 84% | 10.69 | 386 / 459 |
| spleen | 89% | 104.40 | 214 / 241 | 0% | 0 | 0 / 0 |
| thymus | 40% | 24.70 | 260 / 653 | 12% | 0.77 | 73 / 605 |
| ovary | 2% | 1.07 | 3 / 180 | 38% | 2.24 | 163 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 1.60 | 9 / 29 |
| adrenal gland | 3% | 1.86 | 9 / 258 | 27% | 2.22 | 62 / 230 |
| adipose | 22% | 15.96 | 266 / 1204 | 0% | 0 | 0 / 0 |
| heart | 14% | 8.88 | 121 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 7% | 5.02 | 95 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.25 | 5 / 80 |
| muscle | 1% | 0.35 | 5 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010756 | Biological process | positive regulation of plasminogen activation |
| GO_0002353 | Biological process | plasma kallikrein-kinin cascade |
| GO_0045087 | Biological process | innate immune response |
| GO_0016540 | Biological process | protein autoprocessing |
| GO_0016485 | Biological process | protein processing |
| GO_0007596 | Biological process | blood coagulation |
| GO_0051919 | Biological process | positive regulation of fibrinolysis |
| GO_0042730 | Biological process | fibrinolysis |
| GO_0031638 | Biological process | zymogen activation |
| GO_0051788 | Biological process | response to misfolded protein |
| GO_0030194 | Biological process | positive regulation of blood coagulation |
| GO_0007597 | Biological process | blood coagulation, intrinsic pathway |
| GO_0002542 | Biological process | Factor XII activation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005791 | Cellular component | rough endoplasmic reticulum |
| GO_0051787 | Molecular function | misfolded protein binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | F12 |
| Protein name | Coagulation factor XII Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)] Coagulation factor XII (EC 3.4.21.38) (Hageman factor) |
| Synonyms | |
| Description | FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. . |
| Accessions | ENST00000253496.4 A0AA51Z0K1 A0A8Q3WL35 ENST00000696201.1 P00748 A0A346D5N4 A0A0R7FJH5 A0AA51Z3R2 A0A8Q3WL37 A0A8Q3WL25 A0A8Q3WL28 ENST00000696192.1 Q1JR85 ENST00000696193.1 ENST00000696194.1 |
