PZP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PZP at tissue level.

III. Associated gene sets

GO_0007565Biological processfemale pregnancy
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0002020Molecular functionprotease binding
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity

IV. Literature review

[source]
Gene namePZP
Protein namePregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)
Alternative protein PZP
PZP alpha-2-macroglobulin like
SynonymsCPAMD6
DescriptionFUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

AccessionsP20742
ENST00000261336.7 [P20742-1]
F5GXY0
L8EC98
ENST00000535230.5