COMP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COMP at tissue level.

III. Associated gene sets

GO_0048844Biological processartery morphogenesis
GO_0010468Biological processregulation of gene expression
GO_0006986Biological processresponse to unfolded protein
GO_0051260Biological processprotein homooligomerization
GO_0003417Biological processgrowth plate cartilage development
GO_0035989Biological processtendon development
GO_0070527Biological processplatelet aggregation
GO_0009887Biological processanimal organ morphogenesis
GO_0060173Biological processlimb development
GO_0035988Biological processchondrocyte proliferation
GO_0016485Biological processprotein processing
GO_0030500Biological processregulation of bone mineralization
GO_0035264Biological processmulticellular organism growth
GO_0097084Biological processvascular associated smooth muscle cell development
GO_0014829Biological processvascular associated smooth muscle contraction
GO_1990079Biological processcartilage homeostasis
GO_0002063Biological processchondrocyte development
GO_0030509Biological processBMP signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_1902732Biological processpositive regulation of chondrocyte proliferation
GO_0030282Biological processbone mineralization
GO_1900047Biological processnegative regulation of hemostasis
GO_0006915Biological processapoptotic process
GO_0001501Biological processskeletal system development
GO_0090398Biological processcellular senescence
GO_0030199Biological processcollagen fibril organization
GO_0050881Biological processmusculoskeletal movement
GO_0043588Biological processskin development
GO_0009306Biological processprotein secretion
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0008201Molecular functionheparin binding
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005178Molecular functionintegrin binding
GO_0002020Molecular functionprotease binding
GO_0036122Molecular functionBMP binding
GO_0043395Molecular functionheparan sulfate proteoglycan binding
GO_0043394Molecular functionproteoglycan binding
GO_0005509Molecular functioncalcium ion binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOMP
Protein nameCartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)
Cartilage oligomeric matrix protein
Alternative protein COMP
SynonymshCG_37043
DescriptionFUNCTION: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors . Could play a role in the pathogenesis of osteoarthritis . Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) . Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). .

AccessionsENST00000542601.6
L8E6U6
P49747
ENST00000222271.7 [P49747-1]
ENST00000425807.1 [P49747-2]
G3XAP6