SERPINB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	36% ± 13%	Explore
natural killer cell	32 studies	35% ± 11%	Explore
B cell	30 studies	24% ± 8%	Explore
classical monocyte	29 studies	65% ± 15%	Explore
conventional dendritic cell	28 studies	54% ± 17%	Explore
dendritic cell	24 studies	50% ± 21%	Explore
mast cell	24 studies	43% ± 15%	Explore
non-classical monocyte	24 studies	52% ± 13%	Explore
CD4-positive, alpha-beta T cell	23 studies	24% ± 7%	Explore
CD8-positive, alpha-beta T cell	23 studies	27% ± 10%	Explore
monocyte	22 studies	50% ± 19%	Explore
memory B cell	20 studies	24% ± 7%	Explore
endothelial cell	19 studies	29% ± 13%	Explore
regulatory T cell	19 studies	28% ± 7%	Explore
T cell	18 studies	27% ± 6%	Explore
ciliated cell	17 studies	49% ± 18%	Explore
naive B cell	17 studies	22% ± 5%	Explore
mature NK T cell	16 studies	28% ± 8%	Explore
basal cell	16 studies	33% ± 15%	Explore
epithelial cell	16 studies	44% ± 20%	Explore
gamma-delta T cell	16 studies	27% ± 7%	Explore
plasmacytoid dendritic cell	14 studies	29% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	40% ± 11%	Explore
myeloid cell	13 studies	48% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	33% ± 11%	Explore
neutrophil	12 studies	49% ± 14%	Explore
fibroblast	11 studies	26% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	29% ± 11%	Explore
secretory cell	11 studies	44% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	27% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	29% ± 5%	Explore
platelet	10 studies	38% ± 11%	Explore
goblet cell	10 studies	37% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	29% ± 5%	Explore
hematopoietic stem cell	9 studies	71% ± 27%	Explore
mucosal invariant T cell	9 studies	25% ± 4%	Explore
vein endothelial cell	9 studies	31% ± 11%	Explore
endothelial cell of vascular tree	9 studies	36% ± 8%	Explore
type I pneumocyte	8 studies	35% ± 16%	Explore
leukocyte	8 studies	32% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 8%	Explore
type II pneumocyte	7 studies	43% ± 16%	Explore
respiratory goblet cell	7 studies	35% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 14%	Explore
alveolar macrophage	6 studies	40% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	23% ± 7%	Explore
hematopoietic precursor cell	6 studies	67% ± 19%	Explore
club cell	6 studies	46% ± 13%	Explore
mononuclear phagocyte	6 studies	44% ± 19%	Explore
enterocyte	6 studies	30% ± 9%	Explore
innate lymphoid cell	6 studies	33% ± 14%	Explore
capillary endothelial cell	6 studies	37% ± 14%	Explore
T follicular helper cell	6 studies	28% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	27% ± 9%	Explore
granulocyte	6 studies	48% ± 16%	Explore
plasma cell	5 studies	25% ± 6%	Explore
smooth muscle cell	5 studies	19% ± 3%	Explore
ionocyte	5 studies	27% ± 4%	Explore
intestinal crypt stem cell	5 studies	31% ± 10%	Explore
abnormal cell	5 studies	29% ± 6%	Explore
progenitor cell	5 studies	52% ± 25%	Explore
microglial cell	5 studies	26% ± 9%	Explore
endothelial cell of artery	5 studies	21% ± 5%	Explore
intermediate monocyte	5 studies	61% ± 20%	Explore
squamous epithelial cell	4 studies	53% ± 18%	Explore
monocyte-derived dendritic cell	4 studies	68% ± 11%	Explore
exhausted T cell	4 studies	36% ± 1%	Explore
megakaryocyte	4 studies	59% ± 9%	Explore
immature B cell	4 studies	31% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	73% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 9%	Explore
duct epithelial cell	3 studies	37% ± 0%	Explore
plasmablast	3 studies	36% ± 13%	Explore
pancreatic A cell	3 studies	43% ± 9%	Explore
glomerular endothelial cell	3 studies	22% ± 4%	Explore
transit amplifying cell	3 studies	29% ± 9%	Explore
extravillous trophoblast	3 studies	24% ± 6%	Explore
common myeloid progenitor	3 studies	76% ± 19%	Explore
erythroblast	3 studies	38% ± 12%	Explore
pro-B cell	3 studies	34% ± 7%	Explore
serous secreting cell	3 studies	33% ± 24%	Explore
tissue-resident macrophage	3 studies	30% ± 9%	Explore
germinal center B cell	3 studies	28% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	29% ± 2%	Explore
inflammatory macrophage	3 studies	36% ± 6%	Explore
acinar cell	3 studies	72% ± 10%	Explore
pancreatic ductal cell	3 studies	46% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	57% ± 8%	Explore
T-helper 17 cell	3 studies	22% ± 1%	Explore
T-helper 1 cell	3 studies	28% ± 5%	Explore
double negative thymocyte	3 studies	40% ± 3%	Explore
pericyte	3 studies	24% ± 7%	Explore
erythrocyte	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	40% ± 10%	Explore
lung	16 studies	38% ± 15%	Explore
intestine	8 studies	23% ± 7%	Explore
bone marrow	5 studies	32% ± 10%	Explore
pancreas	4 studies	38% ± 6%	Explore
placenta	4 studies	25% ± 5%	Explore
uterus	4 studies	31% ± 12%	Explore
lymph node	4 studies	26% ± 8%	Explore
breast	4 studies	20% ± 2%	Explore
brain	4 studies	17% ± 3%	Explore
kidney	3 studies	32% ± 5%	Explore
esophagus	3 studies	44% ± 22%	Explore
prostate	3 studies	23% ± 3%	Explore
liver	3 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	7040.99	359 / 359	100%	232.78	285 / 286
lung	100%	11588.37	577 / 578	99%	207.71	1147 / 1155
intestine	99%	5620.87	958 / 966	100%	287.47	526 / 527
esophagus	99%	23190.15	1436 / 1445	99%	261.56	181 / 183
thymus	99%	3394.69	647 / 653	99%	100.08	597 / 605
pancreas	100%	17392.49	328 / 328	97%	241.77	173 / 178
kidney	99%	3553.26	88 / 89	96%	91.97	868 / 901
breast	100%	3630.49	457 / 459	95%	83.36	1065 / 1118
adrenal gland	100%	6924.76	258 / 258	91%	65.44	210 / 230
bladder	100%	2465.52	21 / 21	90%	176.55	456 / 504
skin	84%	1991.42	1522 / 1809	91%	77.82	428 / 472
ovary	84%	1801.19	152 / 180	90%	72.25	386 / 430
uterus	81%	1844.31	137 / 170	92%	179.81	420 / 459
liver	53%	1864.62	119 / 226	90%	71.12	364 / 406
prostate	83%	2125.04	204 / 245	25%	11.37	127 / 502
lymph node	0%	0	0 / 0	100%	184.85	29 / 29
spleen	100%	8858.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	291.13	45 / 45
adipose	100%	4232.17	1198 / 1204	0%	0	0 / 0
blood vessel	96%	3008.87	1275 / 1335	0%	0	0 / 0
peripheral blood	94%	29009.55	875 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	79%	52.94	63 / 80
heart	73%	1937.23	630 / 861	0%	0	0 / 0
muscle	67%	3540.94	541 / 803	0%	0	0 / 0
brain	24%	489.08	643 / 2642	35%	19.27	247 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0044342	Biological process	type B pancreatic cell proliferation
GO_0010951	Biological process	negative regulation of endopeptidase activity
GO_0005615	Cellular component	extracellular space
GO_0044194	Cellular component	cytolytic granule
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0016020	Cellular component	membrane
GO_0034774	Cellular component	secretory granule lumen
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0005769	Cellular component	early endosome
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0030414	Molecular function	peptidase inhibitor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SERPINB1
Protein name	Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) Epididymis luminal protein 57 (Epididymis secretory protein Li 27) (Serpin peptidase inhibitor, clade B (Ovalbumin), member 1, isoform CRA_a)
Synonyms	hCG_1641505 MNEI HEL57 HEL-S-27 ELANH2 PI2
Description	FUNCTION: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis . Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 . Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity . During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation . When secreted, promotes the proliferation of beta-cells via its protease inhibitory function . .
Accessions	V9HWH1 ENST00000380739.6 [P30740-1] P30740

SERPINB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review