Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 33 studies | 40% ± 18% | |
connective tissue cell | 13 studies | 45% ± 21% | |
smooth muscle cell | 13 studies | 31% ± 9% | |
myofibroblast cell | 12 studies | 41% ± 14% | |
pericyte | 12 studies | 40% ± 14% | |
endothelial cell | 6 studies | 27% ± 14% | |
mesothelial cell | 6 studies | 54% ± 19% | |
endothelial cell of artery | 4 studies | 35% ± 17% | |
epithelial cell | 4 studies | 22% ± 5% | |
adventitial cell | 4 studies | 28% ± 17% | |
basal cell | 3 studies | 20% ± 1% | |
capillary endothelial cell | 3 studies | 24% ± 12% | |
astrocyte | 3 studies | 23% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 6933.36 | 653 / 653 | 99% | 81.34 | 596 / 605 |
ovary | 100% | 8565.79 | 180 / 180 | 98% | 57.15 | 420 / 430 |
kidney | 100% | 4236.87 | 89 / 89 | 94% | 59.06 | 843 / 901 |
breast | 100% | 5189.86 | 459 / 459 | 93% | 33.76 | 1044 / 1118 |
prostate | 100% | 6644.40 | 245 / 245 | 87% | 23.07 | 436 / 502 |
lung | 100% | 5774.20 | 577 / 578 | 86% | 25.44 | 993 / 1155 |
bladder | 100% | 6238.76 | 21 / 21 | 83% | 25.38 | 416 / 504 |
skin | 92% | 5753.41 | 1667 / 1809 | 80% | 31.92 | 377 / 472 |
uterus | 100% | 9314.05 | 170 / 170 | 65% | 32.02 | 297 / 459 |
intestine | 92% | 5390.49 | 889 / 966 | 71% | 18.13 | 375 / 527 |
brain | 96% | 2073.38 | 2527 / 2642 | 67% | 32.47 | 469 / 705 |
adrenal gland | 99% | 2999.98 | 256 / 258 | 57% | 12.46 | 131 / 230 |
stomach | 75% | 3042.66 | 271 / 359 | 74% | 19.13 | 213 / 286 |
pancreas | 52% | 776.49 | 171 / 328 | 94% | 53.19 | 168 / 178 |
esophagus | 86% | 4729.50 | 1245 / 1445 | 56% | 13.30 | 102 / 183 |
adipose | 100% | 5953.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9128.80 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 28.51 | 1 / 1 |
heart | 100% | 6062.89 | 858 / 861 | 0% | 0 | 0 / 0 |
spleen | 99% | 2807.18 | 239 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 72% | 11.25 | 21 / 29 |
muscle | 63% | 957.92 | 506 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 60% | 14.96 | 48 / 80 |
liver | 16% | 265.14 | 37 / 226 | 30% | 5.72 | 122 / 406 |
tonsil | 0% | 0 | 0 / 0 | 36% | 8.34 | 16 / 45 |
peripheral blood | 18% | 252.92 | 169 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035904 | Biological process | aorta development |
GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
GO_0097084 | Biological process | vascular associated smooth muscle cell development |
GO_1905609 | Biological process | positive regulation of smooth muscle cell-matrix adhesion |
GO_0060414 | Biological process | aorta smooth muscle tissue morphogenesis |
GO_1904028 | Biological process | positive regulation of collagen fibril organization |
GO_1904026 | Biological process | regulation of collagen fibril organization |
GO_0048251 | Biological process | elastic fiber assembly |
GO_1904831 | Biological process | positive regulation of aortic smooth muscle cell differentiation |
GO_0071953 | Cellular component | elastic fiber |
GO_0005576 | Cellular component | extracellular region |
GO_0001527 | Cellular component | microfibril |
GO_0070062 | Cellular component | extracellular exosome |
GO_1903561 | Cellular component | extracellular vesicle |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0031012 | Cellular component | extracellular matrix |
GO_0005604 | Cellular component | basement membrane |
GO_0008201 | Molecular function | heparin binding |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005201 | Molecular function | extracellular matrix structural constituent |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | EFEMP2 |
Protein name | EFEMP2 protein EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1) EGF containing fibulin extracellular matrix protein 2 |
Synonyms | UNQ200/PRO226 FBLN4 |
Description | FUNCTION: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta . In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction . Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling . . |
Accessions | E9PRU1 ENST00000530806.5 ENST00000533347.5 ENST00000526911.1 E9PKA3 ENST00000527277.5 ENST00000527378.1 E9PSC1 ENST00000524408.1 H0YCB5 ENST00000531972.5 E9PNB8 H0YET5 ENST00000307998.11 ENST00000531645.5 ENST00000530850.1 H0YEU0 ENST00000526624.5 H0YCR9 O95967 Q6FH22 E9PI47 E9PRQ8 ENST00000528176.5 |