PLSCR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000373Biological processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO_0045071Biological processnegative regulation of viral genome replication
GO_0070782Biological processphosphatidylserine exposure on apoptotic cell surface
GO_0006953Biological processacute-phase response
GO_0060368Biological processregulation of Fc receptor mediated stimulatory signaling pathway
GO_0010628Biological processpositive regulation of gene expression
GO_0051607Biological processdefense response to virus
GO_0010288Biological processresponse to lead ion
GO_0006659Biological processphosphatidylserine biosynthetic process
GO_0033003Biological processregulation of mast cell activation
GO_0045089Biological processpositive regulation of innate immune response
GO_0030168Biological processplatelet activation
GO_0046718Biological processsymbiont entry into host cell
GO_0050765Biological processnegative regulation of phagocytosis
GO_1905820Biological processpositive regulation of chromosome separation
GO_0006915Biological processapoptotic process
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0035456Biological processresponse to interferon-beta
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0045340Molecular functionmercury ion binding
GO_0017128Molecular functionphospholipid scramblase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0001618Molecular functionvirus receptor activity
GO_0000287Molecular functionmagnesium ion binding
GO_0032791Molecular functionlead ion binding
GO_0008270Molecular functionzinc ion binding
GO_0004518Molecular functionnuclease activity
GO_0042609Molecular functionCD4 receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene namePLSCR1
Protein namePhospholipid scramblase
Phospholipid scramblase 1
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)
PLSCR1 protein (Phospholipid scramblase 1, isoform CRA_f)
SynonymshCG_17108
DescriptionFUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface . Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A . Negatively regulates FcR-mediated phagocytosis in differentiated macrophages . May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes . Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions . Mediates also the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP . Plays a crucial role as a defense factor against SARS-CoV-2 independently of its scramblase activity by directly targeting nascent viral vesicles to prevent virus-membrane fusion and the release of viral RNA into the host-cell cytosol . .; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

AccessionsENST00000468985.5
ENST00000493432.5
ENST00000489775.5
C9J0H3
ENST00000478267.5
F2Z3F2
ENST00000483300.5
H7C5I5
ENST00000463777.5
ENST00000462666.5
C9J9P4
C9J7K9
ENST00000448787.6 [O15162-2]
ENST00000487389.5
C9JE06
ENST00000486631.5
Q8WVK1
O15162
ENST00000488253.5
ENST00000472349.1
ENST00000342435.9 [O15162-1]