ADAMTS5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADAMTS5 at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_0003180Biological processaortic valve morphogenesis
GO_0003203Biological processendocardial cushion morphogenesis
GO_0006508Biological processproteolysis
GO_0042742Biological processdefense response to bacterium
GO_0003184Biological processpulmonary valve morphogenesis
GO_0007520Biological processmyoblast fusion
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0008201Molecular functionheparin binding
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0005178Molecular functionintegrin binding
GO_0008270Molecular functionzinc ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0050840Molecular functionextracellular matrix binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameADAMTS5
Protein nameADAM metallopeptidase with thrombospondin type 1 motif 5
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)
SynonymsADMP2
ADAMTS11
DescriptionFUNCTION: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN . Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. .

AccessionsENST00000284987.6
A0A494C1E4
ENST00000652031.1
Q9UNA0