COL8A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0035987Biological processendodermal cell differentiation
GO_0030198Biological processextracellular matrix organization
GO_0007155Biological processcell adhesion
GO_0001935Biological processendothelial cell proliferation
GO_0048593Biological processcamera-type eye morphogenesis
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0005591Cellular componentcollagen type VIII trimer
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOL8A1
Protein nameCollagen type VIII alpha 1 chain
Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]
SynonymsC3orf7
DescriptionFUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. .; FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. .

AccessionsA0A087WZI0
ENST00000261037.7
ENST00000452013.5
ENST00000652472.1
P27658
C9JTN9
ENST00000621757.1
ENST00000273342.8