COL18A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009887Biological processanimal organ morphogenesis
GO_0051599Biological processresponse to hydrostatic pressure
GO_0007155Biological processcell adhesion
GO_0001501Biological processskeletal system development
GO_0030199Biological processcollagen fibril organization
GO_0001886Biological processendothelial cell morphogenesis
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0030903Biological processnotochord development
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0005581Cellular componentcollagen trimer
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005604Cellular componentbasement membrane
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCOL18A1
Protein nameAlternative protein COL18A1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Collagen alpha-1(XVIII) chain isoform 1 preproprotein
Collagen type XVIII alpha 1 chain
Synonyms
DescriptionFUNCTION: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. .; FUNCTION: [Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. .; FUNCTION: [Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis . May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 . .

AccessionsA0A1B1PFY7
ENST00000651438.1 [P39060-2]
H7BXV5
H7C457
ENST00000423214.1
L8ECK6
ENST00000342220.9
P39060
ENST00000359759.8 [P39060-3]
ENST00000355480.10 [P39060-1]