SERPINB6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	41% ± 15%	Explore
macrophage	32 studies	32% ± 12%	Explore
fibroblast	29 studies	25% ± 9%	Explore
pericyte	26 studies	33% ± 10%	Explore
smooth muscle cell	23 studies	26% ± 8%	Explore
classical monocyte	20 studies	27% ± 12%	Explore
endothelial cell of lymphatic vessel	18 studies	32% ± 9%	Explore
ciliated cell	17 studies	50% ± 16%	Explore
mast cell	16 studies	28% ± 9%	Explore
conventional dendritic cell	16 studies	27% ± 8%	Explore
capillary endothelial cell	15 studies	42% ± 15%	Explore
natural killer cell	14 studies	21% ± 6%	Explore
monocyte	13 studies	22% ± 7%	Explore
non-classical monocyte	13 studies	27% ± 15%	Explore
endothelial cell of artery	13 studies	43% ± 15%	Explore
vein endothelial cell	13 studies	32% ± 10%	Explore
endothelial cell of vascular tree	13 studies	33% ± 15%	Explore
myofibroblast cell	12 studies	28% ± 8%	Explore
connective tissue cell	12 studies	28% ± 8%	Explore
epithelial cell	12 studies	36% ± 19%	Explore
microglial cell	11 studies	32% ± 12%	Explore
myeloid cell	11 studies	27% ± 10%	Explore
astrocyte	11 studies	38% ± 19%	Explore
goblet cell	9 studies	34% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 7%	Explore
dendritic cell	8 studies	41% ± 25%	Explore
alveolar macrophage	7 studies	21% ± 5%	Explore
type I pneumocyte	7 studies	25% ± 10%	Explore
basal cell	7 studies	34% ± 19%	Explore
hematopoietic precursor cell	6 studies	35% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	22% ± 8%	Explore
progenitor cell	6 studies	31% ± 8%	Explore
enterocyte	6 studies	41% ± 9%	Explore
hematopoietic stem cell	6 studies	33% ± 7%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 9%	Explore
secretory cell	6 studies	34% ± 21%	Explore
club cell	5 studies	28% ± 12%	Explore
mononuclear phagocyte	5 studies	32% ± 15%	Explore
transit amplifying cell	5 studies	26% ± 9%	Explore
oligodendrocyte	5 studies	29% ± 8%	Explore
respiratory goblet cell	4 studies	32% ± 26%	Explore
glomerular endothelial cell	4 studies	47% ± 6%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 5%	Explore
enteroendocrine cell	4 studies	38% ± 11%	Explore
intestinal crypt stem cell	4 studies	32% ± 13%	Explore
leukocyte	4 studies	24% ± 4%	Explore
abnormal cell	4 studies	28% ± 6%	Explore
platelet	4 studies	19% ± 2%	Explore
cardiac muscle cell	4 studies	16% ± 1%	Explore
glial cell	4 studies	29% ± 11%	Explore
Mueller cell	4 studies	29% ± 4%	Explore
luminal cell of prostate epithelium	4 studies	24% ± 2%	Explore
brush cell	4 studies	18% ± 1%	Explore
pancreatic A cell	3 studies	34% ± 7%	Explore
type B pancreatic cell	3 studies	34% ± 7%	Explore
mature NK T cell	3 studies	23% ± 10%	Explore
extravillous trophoblast	3 studies	54% ± 9%	Explore
placental villous trophoblast	3 studies	36% ± 13%	Explore
common myeloid progenitor	3 studies	39% ± 22%	Explore
lymphocyte	3 studies	23% ± 6%	Explore
megakaryocyte	3 studies	46% ± 24%	Explore
mesothelial cell	3 studies	42% ± 19%	Explore
serous secreting cell	3 studies	17% ± 0%	Explore
adipocyte	3 studies	19% ± 1%	Explore
tissue-resident macrophage	3 studies	26% ± 3%	Explore
retinal rod cell	3 studies	17% ± 2%	Explore
neuron	3 studies	36% ± 11%	Explore
endothelial cell of sinusoid	3 studies	34% ± 7%	Explore
type II pneumocyte	3 studies	25% ± 7%	Explore
GABAergic neuron	3 studies	31% ± 9%	Explore
pancreatic ductal cell	3 studies	40% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 11%	Explore
gamma-delta T cell	3 studies	19% ± 2%	Explore
innate lymphoid cell	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	30% ± 15%	Explore
intestine	8 studies	29% ± 11%	Explore
peripheral blood	7 studies	24% ± 10%	Explore
brain	6 studies	32% ± 9%	Explore
eye	5 studies	22% ± 6%	Explore
kidney	4 studies	20% ± 5%	Explore
placenta	4 studies	31% ± 7%	Explore
uterus	4 studies	31% ± 8%	Explore
pancreas	3 studies	38% ± 9%	Explore
prostate	3 studies	15% ± 0%	Explore
liver	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	7552.73	328 / 328	100%	46.31	178 / 178
prostate	100%	11503.86	245 / 245	100%	77.74	502 / 502
thymus	100%	7878.27	653 / 653	100%	30.50	604 / 605
kidney	100%	8160.84	89 / 89	100%	33.57	899 / 901
intestine	100%	9375.54	966 / 966	100%	45.96	525 / 527
adrenal gland	100%	10743.57	258 / 258	100%	38.44	229 / 230
stomach	100%	6296.19	359 / 359	99%	37.07	284 / 286
brain	100%	4236.36	2635 / 2642	99%	29.92	701 / 705
bladder	100%	7460.43	21 / 21	99%	33.67	498 / 504
breast	100%	7656.75	459 / 459	98%	30.95	1099 / 1118
lung	100%	11260.30	578 / 578	98%	26.33	1129 / 1155
uterus	100%	8480.15	170 / 170	97%	29.85	445 / 459
skin	99%	4076.80	1799 / 1809	97%	28.50	458 / 472
ovary	100%	11753.23	180 / 180	95%	18.15	409 / 430
esophagus	100%	7893.09	1445 / 1445	95%	24.30	174 / 183
liver	93%	2269.88	210 / 226	95%	16.23	384 / 406
adipose	100%	7975.15	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	35.27	80 / 80
muscle	100%	8800.81	803 / 803	0%	0	0 / 0
spleen	100%	11424.30	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	48.61	1 / 1
blood vessel	100%	8134.31	1334 / 1335	0%	0	0 / 0
heart	100%	9473.10	858 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	20.32	43 / 45
lymph node	0%	0	0 / 0	93%	21.92	27 / 29
peripheral blood	73%	2316.12	679 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0071470	Biological process	cellular response to osmotic stress
GO_0010951	Biological process	negative regulation of endopeptidase activity
GO_0097180	Cellular component	serine protease inhibitor complex
GO_0005615	Cellular component	extracellular space
GO_0030667	Cellular component	secretory granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0070821	Cellular component	tertiary granule membrane
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005886	Cellular component	plasma membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0002020	Molecular function	protease binding
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity

IV. Literature review

[source]

Gene name	SERPINB6
Protein name	Serpin family B member 6 Serpin B6 Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)
Synonyms	PI6 hCG_22875 PTI
Description	FUNCTION: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. .
Accessions	ENST00000612421.3 ENST00000645421.1 A0A2R8Y6A7 ENST00000645580.1 ENST00000642543.1 A0A2R8YDD0 ENST00000644388.1 ENST00000644777.1 ENST00000644693.1 ENST00000643227.1 A0A2R8YD12 ENST00000644875.1 ENST00000380520.6 A0A2R8Y5S1 A0A2R8Y5Y8 ENST00000380546.7 A0A2R8Y6N4 ENST00000646775.1 ENST00000380539.7 ENST00000644178.1 A0A024QZX5 ENST00000380524.5 A0A087X1N8 A0A2R8Y7E5 ENST00000380529.5 A0A2R8Y517 ENST00000616722.4 ENST00000644828.1 A0A3B3ISC3 P35237 ENST00000649845.1 ENST00000643098.1 ENST00000646688.1

SERPINB6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review