ANXA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	47 studies	61% ± 24%	Explore
endothelial cell	46 studies	62% ± 23%	Explore
macrophage	42 studies	54% ± 25%	Explore
natural killer cell	35 studies	32% ± 13%	Explore
pericyte	33 studies	54% ± 19%	Explore
endothelial cell of lymphatic vessel	30 studies	75% ± 24%	Explore
classical monocyte	29 studies	71% ± 14%	Explore
conventional dendritic cell	29 studies	69% ± 22%	Explore
dendritic cell	27 studies	65% ± 22%	Explore
smooth muscle cell	27 studies	46% ± 21%	Explore
T cell	26 studies	39% ± 18%	Explore
monocyte	26 studies	57% ± 21%	Explore
non-classical monocyte	26 studies	76% ± 13%	Explore
CD8-positive, alpha-beta T cell	26 studies	36% ± 19%	Explore
basal cell	25 studies	79% ± 19%	Explore
epithelial cell	25 studies	79% ± 19%	Explore
B cell	24 studies	23% ± 8%	Explore
ciliated cell	21 studies	81% ± 19%	Explore
CD4-positive, alpha-beta T cell	21 studies	35% ± 20%	Explore
regulatory T cell	20 studies	39% ± 18%	Explore
connective tissue cell	20 studies	59% ± 22%	Explore
plasma cell	18 studies	40% ± 15%	Explore
mature NK T cell	17 studies	32% ± 12%	Explore
myeloid cell	17 studies	59% ± 23%	Explore
gamma-delta T cell	17 studies	28% ± 8%	Explore
capillary endothelial cell	15 studies	58% ± 17%	Explore
endothelial cell of vascular tree	15 studies	64% ± 26%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 10%	Explore
plasmacytoid dendritic cell	14 studies	34% ± 9%	Explore
endothelial cell of artery	14 studies	64% ± 14%	Explore
myofibroblast cell	14 studies	47% ± 20%	Explore
vein endothelial cell	14 studies	68% ± 22%	Explore
memory B cell	14 studies	30% ± 9%	Explore
type I pneumocyte	13 studies	80% ± 18%	Explore
mesothelial cell	13 studies	66% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	35% ± 16%	Explore
club cell	12 studies	75% ± 23%	Explore
secretory cell	12 studies	86% ± 12%	Explore
mucosal invariant T cell	12 studies	31% ± 6%	Explore
type II pneumocyte	11 studies	50% ± 20%	Explore
goblet cell	11 studies	68% ± 20%	Explore
plasmablast	10 studies	55% ± 19%	Explore
progenitor cell	10 studies	61% ± 25%	Explore
abnormal cell	10 studies	47% ± 26%	Explore
adipocyte	10 studies	44% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	38% ± 21%	Explore
respiratory goblet cell	9 studies	79% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	51% ± 24%	Explore
enterocyte	9 studies	56% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 11%	Explore
alveolar macrophage	8 studies	74% ± 21%	Explore
mononuclear phagocyte	8 studies	54% ± 24%	Explore
neutrophil	8 studies	33% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	27% ± 8%	Explore
ionocyte	7 studies	66% ± 19%	Explore
leukocyte	7 studies	45% ± 17%	Explore
mast cell	7 studies	22% ± 8%	Explore
mucus secreting cell	7 studies	56% ± 22%	Explore
melanocyte	7 studies	73% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
podocyte	6 studies	71% ± 24%	Explore
innate lymphoid cell	6 studies	37% ± 22%	Explore
glial cell	6 studies	63% ± 16%	Explore
intermediate monocyte	6 studies	65% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 24%	Explore
CD4-positive helper T cell	5 studies	34% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	45% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 11%	Explore
duct epithelial cell	5 studies	83% ± 6%	Explore
transit amplifying cell	5 studies	76% ± 16%	Explore
lymphocyte	5 studies	66% ± 28%	Explore
neuroendocrine cell	5 studies	60% ± 25%	Explore
Schwann cell	5 studies	59% ± 27%	Explore
adventitial cell	5 studies	69% ± 27%	Explore
inflammatory macrophage	5 studies	47% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	67% ± 11%	Explore
keratinocyte	5 studies	83% ± 18%	Explore
deuterosomal cell	4 studies	79% ± 14%	Explore
squamous epithelial cell	4 studies	75% ± 10%	Explore
pancreatic A cell	4 studies	48% ± 26%	Explore
monocyte-derived dendritic cell	4 studies	81% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	44% ± 13%	Explore
cholangiocyte	4 studies	44% ± 24%	Explore
exhausted T cell	4 studies	41% ± 26%	Explore
glomerular endothelial cell	4 studies	50% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	37% ± 13%	Explore
epithelial cell of proximal tubule	4 studies	26% ± 12%	Explore
enteroendocrine cell	4 studies	45% ± 16%	Explore
intestinal crypt stem cell	4 studies	62% ± 16%	Explore
astrocyte	4 studies	27% ± 10%	Explore
retinal ganglion cell	4 studies	76% ± 20%	Explore
kidney loop of Henle epithelial cell	4 studies	44% ± 13%	Explore
endothelial cell of sinusoid	4 studies	46% ± 30%	Explore
muscle cell	4 studies	35% ± 16%	Explore
neuron	4 studies	30% ± 16%	Explore
double negative thymocyte	4 studies	43% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	89% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	78% ± 22%	Explore
Langerhans cell	3 studies	68% ± 23%	Explore
hillock cell	3 studies	79% ± 22%	Explore
platelet	3 studies	32% ± 19%	Explore
naive B cell	3 studies	25% ± 9%	Explore
neural crest cell	3 studies	36% ± 9%	Explore
extravillous trophoblast	3 studies	99% ± 1%	Explore
placental villous trophoblast	3 studies	96% ± 5%	Explore
precursor B cell	3 studies	31% ± 9%	Explore
brush cell	3 studies	92% ± 5%	Explore
microglial cell	3 studies	43% ± 19%	Explore
serous secreting cell	3 studies	55% ± 27%	Explore
tissue-resident macrophage	3 studies	52% ± 16%	Explore
acinar cell	3 studies	45% ± 22%	Explore
chondrocyte	3 studies	44% ± 14%	Explore
IgA plasma cell	3 studies	39% ± 15%	Explore
myoepithelial cell	3 studies	85% ± 3%	Explore
granulocyte	3 studies	25% ± 3%	Explore
pancreatic ductal cell	3 studies	95% ± 2%	Explore
hepatocyte	3 studies	53% ± 20%	Explore
T-helper 17 cell	3 studies	58% ± 25%	Explore
T-helper 1 cell	3 studies	55% ± 21%	Explore
hematopoietic precursor cell	3 studies	38% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	25% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	35% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	72% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	56% ± 20%	Explore
peripheral blood	21 studies	40% ± 13%	Explore
intestine	13 studies	42% ± 18%	Explore
kidney	8 studies	38% ± 12%	Explore
eye	6 studies	32% ± 20%	Explore
uterus	6 studies	62% ± 18%	Explore
pancreas	5 studies	45% ± 19%	Explore
bone marrow	5 studies	33% ± 13%	Explore
heart	5 studies	30% ± 10%	Explore
adipose	5 studies	46% ± 19%	Explore
esophagus	5 studies	57% ± 25%	Explore
prostate	5 studies	71% ± 26%	Explore
skin	5 studies	61% ± 25%	Explore
breast	5 studies	60% ± 23%	Explore
placenta	4 studies	75% ± 29%	Explore
liver	4 studies	30% ± 6%	Explore
ovary	3 studies	33% ± 5%	Explore
adrenal gland	3 studies	39% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	46496.56	576 / 578	99%	309.07	1149 / 1155
breast	100%	42897.88	459 / 459	99%	231.89	1105 / 1118
esophagus	99%	53900.01	1433 / 1445	99%	317.90	181 / 183
bladder	100%	27067.33	21 / 21	98%	279.80	493 / 504
skin	100%	105190.97	1809 / 1809	97%	216.38	457 / 472
intestine	94%	21974.64	912 / 966	99%	271.62	524 / 527
uterus	94%	18606.56	159 / 170	98%	362.64	451 / 459
thymus	100%	22546.86	650 / 653	90%	172.15	546 / 605
stomach	84%	15174.04	302 / 359	99%	225.14	284 / 286
kidney	87%	18414.51	77 / 89	95%	146.38	852 / 901
ovary	76%	9309.92	137 / 180	99%	162.26	425 / 430
prostate	100%	25066.60	245 / 245	67%	58.04	337 / 502
pancreas	70%	9830.29	230 / 328	96%	442.07	171 / 178
adrenal gland	95%	21113.41	244 / 258	43%	35.37	98 / 230
adipose	100%	50291.61	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	194.43	1 / 1
blood vessel	100%	35301.51	1329 / 1335	0%	0	0 / 0
spleen	99%	17794.41	239 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	353.21	44 / 45
eye	0%	0	0 / 0	96%	151.79	77 / 80
liver	23%	3827.36	52 / 226	73%	100.05	296 / 406
lymph node	0%	0	0 / 0	86%	94.08	25 / 29
heart	78%	12509.38	675 / 861	0%	0	0 / 0
peripheral blood	63%	8705.29	588 / 929	0%	0	0 / 0
muscle	59%	8509.75	475 / 803	0%	0	0 / 0
brain	4%	504.65	107 / 2642	32%	44.76	228 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032804	Biological process	negative regulation of low-density lipoprotein particle receptor catabolic process
GO_1905581	Biological process	positive regulation of low-density lipoprotein particle clearance
GO_0001525	Biological process	angiogenesis
GO_0001921	Biological process	positive regulation of receptor recycling
GO_0030324	Biological process	lung development
GO_0031340	Biological process	positive regulation of vesicle fusion
GO_0010756	Biological process	positive regulation of plasminogen activation
GO_0007160	Biological process	cell-matrix adhesion
GO_0044090	Biological process	positive regulation of vacuole organization
GO_0014823	Biological process	response to activity
GO_0042730	Biological process	fibrinolysis
GO_1905597	Biological process	positive regulation of low-density lipoprotein particle receptor binding
GO_1905599	Biological process	positive regulation of low-density lipoprotein receptor activity
GO_0036035	Biological process	osteoclast development
GO_1905686	Biological process	positive regulation of plasma membrane repair
GO_0006900	Biological process	vesicle budding from membrane
GO_0042789	Biological process	mRNA transcription by RNA polymerase II
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0002091	Biological process	negative regulation of receptor internalization
GO_0030199	Biological process	collagen fibril organization
GO_0050767	Biological process	regulation of neurogenesis
GO_1905602	Biological process	positive regulation of receptor-mediated endocytosis involved in cholesterol transport
GO_0098609	Biological process	cell-cell adhesion
GO_0045921	Biological process	positive regulation of exocytosis
GO_0001765	Biological process	membrane raft assembly
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0016323	Cellular component	basolateral plasma membrane
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0030496	Cellular component	midbody
GO_0031902	Cellular component	late endosome membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005811	Cellular component	lipid droplet
GO_0045121	Cellular component	membrane raft
GO_0012506	Cellular component	vesicle membrane
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0042383	Cellular component	sarcolemma
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_1990667	Cellular component	PCSK9-AnxA2 complex
GO_0001533	Cellular component	cornified envelope
GO_0016363	Cellular component	nuclear matrix
GO_0043220	Cellular component	Schmidt-Lanterman incisure
GO_0009986	Cellular component	cell surface
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005829	Cellular component	cytosol
GO_0098797	Cellular component	plasma membrane protein complex
GO_0005912	Cellular component	adherens junction
GO_0005737	Cellular component	cytoplasm
GO_0042470	Cellular component	melanosome
GO_0005604	Cellular component	basement membrane
GO_1990665	Cellular component	AnxA2-p11 complex
GO_0005768	Cellular component	endosome
GO_0031982	Cellular component	vesicle
GO_0005765	Cellular component	lysosomal membrane
GO_0035749	Cellular component	myelin sheath adaxonal region
GO_0005634	Cellular component	nucleus
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0019834	Molecular function	phospholipase A2 inhibitor activity
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0042802	Molecular function	identical protein binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0002020	Molecular function	protease binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0098641	Molecular function	cadherin binding involved in cell-cell adhesion
GO_0003723	Molecular function	RNA binding
GO_0044548	Molecular function	S100 protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ANXA2
Protein name	Annexin A2 Annexin Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Synonyms	hCG_2004404 LPC2D ANX2 ANX2L4 CAL1H
Description	FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 . .; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. .
Accessions	H0YL33 H0YNB8 ENST00000560389.5 ENST00000558986.5 ENST00000557906.6 [P07355-1] H0YKN4 ENST00000559370.5 ENST00000678870.1 [P07355-1] H0YMD9 ENST00000559725.5 H0YN42 H0YKS4 H0YKV8 ENST00000557904.5 ENST00000559350.5 ENST00000558558 ENST00000559467.5 H0YMD0 ENST00000421017.6 [P07355-1] ENST00000558132.5 ENST00000558985.6 ENST00000451270.7 [P07355-1] P07355 ENST00000557906 H0YMW4 H0YNP5 H0YM50 H0YKX9 ENST00000558558.6 [P07355-1] H0YLE2 ENST00000559176.5 ENST00000558169.6 H0YNA0 ENST00000560165.5 H0YMU9 ENST00000676687.1 ENST00000678061.1 [P07355-1] ENST00000559113.6 ENST00000560468 ENST00000560367.6 ENST00000559818 ENST00000396024.7 [P07355-1] A0A024R5Z7 ENST00000560466.5 ENST00000558998.5 ENST00000332680.8 [P07355-2] H0YKZ7 H0YMM1 H0YLV6 ENST00000560014.5 ENST00000561022.5 ENST00000559780.6 H0YMT9 ENST00000677968.1 [P07355-1] H0YKL9 A0A7I2V4P4 ENST00000559956 ENST00000558503.6 H0YN28 ENST00000560468.6 [P07355-1] ENST00000678450.1 [P07355-1] ENST00000559818.6 [P07355-1] ENST00000679109.1 [P07355-1] ENST00000559956.6 [P07355-1]

ANXA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review