COL4A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009749Biological processresponse to glucose
GO_1905563Biological processnegative regulation of vascular endothelial cell proliferation
GO_0030198Biological processextracellular matrix organization
GO_0038063Biological processcollagen-activated tyrosine kinase receptor signaling pathway
GO_0007155Biological processcell adhesion
GO_0032836Biological processglomerular basement membrane development
GO_0016525Biological processnegative regulation of angiogenesis
GO_0072577Biological processendothelial cell apoptotic process
GO_0008015Biological processblood circulation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005587Cellular componentcollagen type IV trimer
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005604Cellular componentbasement membrane
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0008191Molecular functionmetalloendopeptidase inhibitor activity
GO_0005198Molecular functionstructural molecule activity
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOL4A3
Protein nameCollagen type IV alpha 3 chain
Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin]
Collagen IV alpha 3 chain
Synonyms
DescriptionFUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.

FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. .

AccessionsENST00000643388.1
ENST00000469504.2
A0A2R8Y6E5
Q01955
A0A2R8Y2F0
H7BXM4
ENST00000396578.8 [Q01955-1]
ENST00000304990.8
Q548X1