Insufficient scRNA-seq data for expression of MMP8 at single-cell level.
Insufficient scRNA-seq data for expression of MMP8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 87% | 600.27 | 504 / 578 | 16% | 0.55 | 188 / 1155 |
spleen | 98% | 1953.68 | 235 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 81% | 11087.06 | 755 / 929 | 0% | 0 | 0 / 0 |
skin | 9% | 5.15 | 166 / 1809 | 61% | 16.11 | 290 / 472 |
adipose | 52% | 66.71 | 631 / 1204 | 0% | 0 | 0 / 0 |
breast | 28% | 34.19 | 129 / 459 | 9% | 0.33 | 104 / 1118 |
liver | 31% | 44.80 | 70 / 226 | 1% | 0.01 | 3 / 406 |
heart | 27% | 29.49 | 230 / 861 | 0% | 0 | 0 / 0 |
thymus | 24% | 17.98 | 155 / 653 | 1% | 0.01 | 4 / 605 |
kidney | 19% | 21.52 | 17 / 89 | 2% | 0.07 | 18 / 901 |
stomach | 8% | 15.26 | 29 / 359 | 11% | 1.69 | 31 / 286 |
brain | 15% | 12.99 | 395 / 2642 | 3% | 0.06 | 21 / 705 |
blood vessel | 17% | 17.74 | 227 / 1335 | 0% | 0 | 0 / 0 |
intestine | 5% | 6.99 | 53 / 966 | 11% | 0.38 | 57 / 527 |
bladder | 10% | 3.81 | 2 / 21 | 7% | 0.18 | 33 / 504 |
pancreas | 2% | 1.13 | 7 / 328 | 12% | 0.34 | 21 / 178 |
esophagus | 5% | 4.31 | 72 / 1445 | 8% | 0.36 | 15 / 183 |
ovary | 8% | 4.75 | 14 / 180 | 4% | 0.09 | 19 / 430 |
adrenal gland | 11% | 5.86 | 28 / 258 | 1% | 0.04 | 2 / 230 |
muscle | 10% | 6.18 | 80 / 803 | 0% | 0 | 0 / 0 |
uterus | 6% | 5.65 | 10 / 170 | 2% | 0.03 | 10 / 459 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.26 | 2 / 29 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.19 | 3 / 45 |
prostate | 6% | 3.90 | 15 / 245 | 0% | 0.00 | 1 / 502 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1903980 | Biological process | positive regulation of microglial cell activation |
GO_1903265 | Biological process | positive regulation of tumor necrosis factor-mediated signaling pathway |
GO_0035987 | Biological process | endodermal cell differentiation |
GO_0030198 | Biological process | extracellular matrix organization |
GO_0022617 | Biological process | extracellular matrix disassembly |
GO_0030574 | Biological process | collagen catabolic process |
GO_0006508 | Biological process | proteolysis |
GO_0071222 | Biological process | cellular response to lipopolysaccharide |
GO_0150078 | Biological process | positive regulation of neuroinflammatory response |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0035580 | Cellular component | specific granule lumen |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_1904724 | Cellular component | tertiary granule lumen |
GO_0008233 | Molecular function | peptidase activity |
GO_0004175 | Molecular function | endopeptidase activity |
GO_0043120 | Molecular function | tumor necrosis factor binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0004222 | Molecular function | metalloendopeptidase activity |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | MMP8 |
Protein name | Matrix metallopeptidase 8 Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) |
Synonyms | CLG1 |
Description | FUNCTION: Can degrade fibrillar type I, II, and III collagens. |
Accessions | E9PIY7 E9PL87 ENST00000531168.1 ENST00000236826.8 ENST00000532799.1 ENST00000533258.5 H7C1M3 ENST00000528662.6 P22894 E9PJB3 ENST00000438475.2 |