COL4A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0035987Biological processendodermal cell differentiation
GO_0030198Biological processextracellular matrix organization
GO_0038063Biological processcollagen-activated tyrosine kinase receptor signaling pathway
GO_0014823Biological processresponse to activity
GO_0016525Biological processnegative regulation of angiogenesis
GO_0006351Biological processDNA-templated transcription
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005587Cellular componentcollagen type IV trimer
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005604Cellular componentbasement membrane
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0060090Molecular functionmolecular adaptor activity
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOL4A2
Protein nameCollagen type IV alpha 2 chain
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
Synonyms
DescriptionFUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

AccessionsA0A3B3IRV2
ENST00000649951.1
A0A3B3IT80
A0A3B3ITQ8
ENST00000619688.2
P08572
A0A3B3ITN7
ENST00000360467.7
ENST00000650540.1
ENST00000649101.1
A0A3B3IS47
A0A3B3IS04
A2A352
ENST00000480609.1
ENST00000617564.2
ENST00000494852.2
A0A087WY39
ENST00000400163.7