OTOL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OTOL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OTOL1 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0030198Biological processextracellular matrix organization
GO_0045299Biological processotolith mineralization
GO_0005615Cellular componentextracellular space
GO_0005581Cellular componentcollagen trimer
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameOTOL1
Protein nameOtolin-1
Synonyms
DescriptionFUNCTION: Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. .

AccessionsA6NHN0
ENST00000327928.4