PRG3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRG3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRG3 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0019370Biological processleukotriene biosynthetic process
GO_0017148Biological processnegative regulation of translation
GO_0045575Biological processbasophil activation
GO_0001694Biological processhistamine biosynthetic process
GO_0042119Biological processneutrophil activation
GO_0042554Biological processsuperoxide anion generation
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_1904724Cellular componenttertiary granule lumen
GO_0035580Cellular componentspecific granule lumen
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0030021Molecular functionextracellular matrix structural constituent conferring compression resistance
GO_0030246Molecular functioncarbohydrate binding

IV. Literature review

[source]
Gene namePRG3
Protein nameProteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH)
SynonymsMBPH
UNQ486/PRO1002
DescriptionFUNCTION: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. .

AccessionsENST00000287143.2
Q9Y2Y8