LTBP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002062Biological processchondrocyte differentiation
GO_0060430Biological processlung saccule development
GO_0046849Biological processbone remodeling
GO_0060349Biological processbone morphogenesis
GO_1902462Biological processpositive regulation of mesenchymal stem cell proliferation
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0030502Biological processnegative regulation of bone mineralization
GO_0030282Biological processbone mineralization
GO_0045780Biological processpositive regulation of bone resorption
GO_2000741Biological processpositive regulation of mesenchymal stem cell differentiation
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLTBP3
Protein nameLatent-transforming growth factor beta-binding protein 3 (LTBP-3)
LTBP3 protein (Latent transforming growth factor beta binding protein 3, isoform CRA_c)
Latent transforming growth factor beta binding protein 3
SynonymshCG_1812642
DescriptionFUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. .

AccessionsENST00000526825.6
ENST00000530866.6
ENST00000322147.8 [Q9NS15-2]
ENST00000528516.5
A0A8I5KYV1
E9PKW1
E9PRF2
H0YC99
ENST00000689505.1
ENST00000301873.11 [Q9NS15-1]
Q9NS15
ENST00000526927.6
H0YE75
B9EG76
E9PPT7
ENST00000532661.6