ELANE report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ELANE at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ELANE at tissue level.

III. Associated gene sets

GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0070947Biological processneutrophil-mediated killing of fungus
GO_0070945Biological processneutrophil-mediated killing of gram-negative bacterium
GO_0002523Biological processleukocyte migration involved in inflammatory response
GO_0022617Biological processextracellular matrix disassembly
GO_0009411Biological processresponse to UV
GO_0070269Biological processpyroptotic inflammatory response
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050922Biological processnegative regulation of chemotaxis
GO_0002812Biological processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO_1903238Biological processpositive regulation of leukocyte tethering or rolling
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0050728Biological processnegative regulation of inflammatory response
GO_0006508Biological processproteolysis
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0006909Biological processphagocytosis
GO_0030163Biological processprotein catabolic process
GO_0042742Biological processdefense response to bacterium
GO_0032682Biological processnegative regulation of chemokine production
GO_0001878Biological processresponse to yeast
GO_0050778Biological processpositive regulation of immune response
GO_0032496Biological processresponse to lipopolysaccharide
GO_0002438Biological processacute inflammatory response to antigenic stimulus
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0017053Cellular componenttranscription repressor complex
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005737Cellular componentcytoplasm
GO_0030141Cellular componentsecretory granule
GO_0008201Molecular functionheparin binding
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0019955Molecular functioncytokine binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0002020Molecular functionprotease binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameELANE
Protein nameNeutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
SynonymsELA2
DescriptionFUNCTION: Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis . Promotes cleavage of GSDMB, thereby inhibiting pyroptosis . Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae . .

AccessionsENST00000615489.1
ENST00000632488.1
P08246
ENST00000263621.2
ENST00000590230.5