CCN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0030324Biological processlung development
GO_0008544Biological processepidermis development
GO_0010629Biological processnegative regulation of gene expression
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0007160Biological processcell-matrix adhesion
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0002062Biological processchondrocyte differentiation
GO_0035988Biological processchondrocyte proliferation
GO_0007155Biological processcell adhesion
GO_0072593Biological processreactive oxygen species metabolic process
GO_0045597Biological processpositive regulation of cell differentiation
GO_0071897Biological processDNA biosynthetic process
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0001503Biological processossification
GO_0001894Biological processtissue homeostasis
GO_0001502Biological processcartilage condensation
GO_0032330Biological processregulation of chondrocyte differentiation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0009611Biological processresponse to wounding
GO_0016477Biological processcell migration
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0008201Molecular functionheparin binding
GO_0005520Molecular functioninsulin-like growth factor binding
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCN2
Protein nameCCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor)
SynonymsCTGF
HCS24
IGFBP8
DescriptionFUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. .

AccessionsP29279
ENST00000367976.4 [P29279-1]
Q5M8T4
Q6FHL8