LGALS3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	39 studies	57% ± 25%	Explore
macrophage	34 studies	54% ± 23%	Explore
endothelial cell	31 studies	47% ± 23%	Explore
classical monocyte	27 studies	66% ± 15%	Explore
conventional dendritic cell	25 studies	54% ± 18%	Explore
non-classical monocyte	24 studies	67% ± 15%	Explore
mast cell	23 studies	51% ± 15%	Explore
endothelial cell of lymphatic vessel	23 studies	64% ± 21%	Explore
epithelial cell	23 studies	73% ± 21%	Explore
pericyte	23 studies	41% ± 21%	Explore
smooth muscle cell	22 studies	43% ± 19%	Explore
monocyte	21 studies	49% ± 18%	Explore
basal cell	21 studies	61% ± 19%	Explore
dendritic cell	20 studies	42% ± 17%	Explore
ciliated cell	19 studies	74% ± 24%	Explore
T cell	16 studies	28% ± 7%	Explore
regulatory T cell	16 studies	38% ± 22%	Explore
connective tissue cell	15 studies	52% ± 22%	Explore
myeloid cell	14 studies	53% ± 23%	Explore
CD8-positive, alpha-beta T cell	14 studies	28% ± 13%	Explore
capillary endothelial cell	13 studies	37% ± 21%	Explore
endothelial cell of vascular tree	13 studies	50% ± 22%	Explore
secretory cell	12 studies	77% ± 21%	Explore
endothelial cell of artery	12 studies	51% ± 16%	Explore
goblet cell	12 studies	68% ± 25%	Explore
type I pneumocyte	11 studies	62% ± 25%	Explore
CD4-positive, alpha-beta T cell	11 studies	34% ± 19%	Explore
vein endothelial cell	11 studies	48% ± 16%	Explore
type II pneumocyte	10 studies	55% ± 23%	Explore
club cell	10 studies	75% ± 27%	Explore
mesothelial cell	10 studies	48% ± 18%	Explore
mucosal invariant T cell	10 studies	23% ± 7%	Explore
myofibroblast cell	10 studies	57% ± 21%	Explore
astrocyte	9 studies	29% ± 15%	Explore
enterocyte	9 studies	76% ± 27%	Explore
alveolar macrophage	8 studies	74% ± 29%	Explore
plasma cell	8 studies	32% ± 8%	Explore
respiratory goblet cell	8 studies	79% ± 25%	Explore
natural killer cell	7 studies	21% ± 3%	Explore
ionocyte	7 studies	86% ± 11%	Explore
abnormal cell	7 studies	39% ± 17%	Explore
progenitor cell	7 studies	73% ± 35%	Explore
erythrocyte	6 studies	34% ± 13%	Explore
plasmablast	6 studies	34% ± 19%	Explore
neutrophil	6 studies	30% ± 10%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 18%	Explore
brush cell	6 studies	62% ± 19%	Explore
gamma-delta T cell	6 studies	21% ± 5%	Explore
mature NK T cell	6 studies	28% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	36% ± 12%	Explore
duct epithelial cell	5 studies	81% ± 29%	Explore
mononuclear phagocyte	5 studies	55% ± 10%	Explore
renal alpha-intercalated cell	5 studies	93% ± 2%	Explore
transit amplifying cell	5 studies	76% ± 24%	Explore
innate lymphoid cell	5 studies	33% ± 16%	Explore
mucus secreting cell	5 studies	59% ± 25%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	43% ± 24%	Explore
intermediate monocyte	5 studies	78% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	45% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	37% ± 16%	Explore
leukocyte	5 studies	39% ± 9%	Explore
melanocyte	5 studies	65% ± 27%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 4%	Explore
deuterosomal cell	4 studies	66% ± 14%	Explore
squamous epithelial cell	4 studies	75% ± 23%	Explore
monocyte-derived dendritic cell	4 studies	58% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	28% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	17% ± 1%	Explore
intestinal crypt stem cell	4 studies	87% ± 5%	Explore
adventitial cell	4 studies	80% ± 13%	Explore
Mueller cell	4 studies	46% ± 4%	Explore
inflammatory macrophage	4 studies	42% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 14%	Explore
T-helper 17 cell	4 studies	39% ± 19%	Explore
renal beta-intercalated cell	3 studies	70% ± 36%	Explore
enteroendocrine cell	3 studies	47% ± 21%	Explore
renal principal cell	3 studies	59% ± 19%	Explore
extravillous trophoblast	3 studies	81% ± 6%	Explore
placental villous trophoblast	3 studies	84% ± 16%	Explore
lymphocyte	3 studies	50% ± 26%	Explore
serous secreting cell	3 studies	47% ± 20%	Explore
adipocyte	3 studies	18% ± 2%	Explore
glial cell	3 studies	34% ± 14%	Explore
tissue-resident macrophage	3 studies	44% ± 18%	Explore
exhausted T cell	3 studies	35% ± 23%	Explore
CD4-positive helper T cell	3 studies	32% ± 10%	Explore
IgA plasma cell	3 studies	27% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	48% ± 30%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	28% ± 5%	Explore
myoepithelial cell	3 studies	57% ± 12%	Explore
granulocyte	3 studies	52% ± 24%	Explore
luminal cell of prostate epithelium	3 studies	56% ± 6%	Explore
pancreatic ductal cell	3 studies	69% ± 1%	Explore
keratinocyte	3 studies	74% ± 13%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	43% ± 23%	Explore
progenitor cell of mammary luminal epithelium	3 studies	69% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	52% ± 21%	Explore
peripheral blood	17 studies	28% ± 7%	Explore
intestine	13 studies	42% ± 25%	Explore
kidney	6 studies	30% ± 12%	Explore
uterus	6 studies	56% ± 24%	Explore
placenta	4 studies	53% ± 24%	Explore
eye	4 studies	31% ± 17%	Explore
adipose	4 studies	26% ± 4%	Explore
prostate	4 studies	57% ± 11%	Explore
breast	4 studies	61% ± 11%	Explore
ovary	3 studies	43% ± 17%	Explore
heart	3 studies	20% ± 1%	Explore
esophagus	3 studies	50% ± 13%	Explore
pancreas	3 studies	19% ± 3%	Explore
liver	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	99%	21538.78	960 / 966	100%	1047.10	525 / 527
stomach	100%	8006.99	358 / 359	99%	767.23	282 / 286
lung	100%	14079.58	577 / 578	98%	453.24	1131 / 1155
esophagus	100%	12701.74	1444 / 1445	98%	438.70	179 / 183
bladder	100%	11486.86	21 / 21	95%	519.79	479 / 504
skin	100%	22148.90	1809 / 1809	94%	845.04	445 / 472
uterus	100%	10265.87	170 / 170	91%	397.79	419 / 459
breast	100%	18600.31	459 / 459	88%	269.63	985 / 1118
kidney	94%	5911.25	84 / 89	93%	369.58	838 / 901
ovary	100%	11973.39	180 / 180	87%	231.80	372 / 430
thymus	92%	4297.99	600 / 653	84%	524.79	507 / 605
prostate	100%	8184.34	245 / 245	71%	151.86	358 / 502
pancreas	42%	1588.96	139 / 328	94%	627.19	167 / 178
adipose	100%	19554.06	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	295.72	1 / 1
adrenal gland	76%	2991.36	196 / 258	23%	47.26	54 / 230
blood vessel	99%	8134.14	1322 / 1335	0%	0	0 / 0
heart	99%	7412.60	850 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	347.52	43 / 45
peripheral blood	94%	5423.99	873 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	211.55	26 / 29
spleen	70%	2370.72	168 / 241	0%	0	0 / 0
brain	31%	1201.20	824 / 2642	31%	113.66	220 / 705
eye	0%	0	0 / 0	49%	152.05	39 / 80
muscle	36%	1415.14	292 / 803	0%	0	0 / 0
liver	1%	68.50	3 / 226	33%	79.51	133 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006397	Biological process	mRNA processing
GO_0030855	Biological process	epithelial cell differentiation
GO_0045087	Biological process	innate immune response
GO_0050918	Biological process	positive chemotaxis
GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_0042129	Biological process	regulation of T cell proliferation
GO_0045806	Biological process	negative regulation of endocytosis
GO_2000521	Biological process	negative regulation of immunological synapse formation
GO_0030593	Biological process	neutrophil chemotaxis
GO_0070232	Biological process	regulation of T cell apoptotic process
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0008380	Biological process	RNA splicing
GO_0071677	Biological process	positive regulation of mononuclear cell migration
GO_2001200	Biological process	positive regulation of dendritic cell differentiation
GO_0048245	Biological process	eosinophil chemotaxis
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_1903614	Biological process	negative regulation of protein tyrosine phosphatase activity
GO_2001189	Biological process	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0071674	Biological process	mononuclear cell migration
GO_0002548	Biological process	monocyte chemotaxis
GO_1902041	Biological process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0090280	Biological process	positive regulation of calcium ion import
GO_0048246	Biological process	macrophage chemotaxis
GO_0001772	Cellular component	immunological synapse
GO_0005615	Cellular component	extracellular space
GO_0030667	Cellular component	secretory granule membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0005634	Cellular component	nucleus
GO_0019863	Molecular function	IgE binding
GO_0019903	Molecular function	protein phosphatase binding
GO_0030246	Molecular function	carbohydrate binding
GO_0004864	Molecular function	protein phosphatase inhibitor activity
GO_0048030	Molecular function	disaccharide binding
GO_0042056	Molecular function	chemoattractant activity
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0003723	Molecular function	RNA binding
GO_0043236	Molecular function	laminin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LGALS3
Protein name	Galectin 3 Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) Galectin
Synonyms	MAC2
Description	FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. .
Accessions	G3V407 ENST00000554715.1 P17931 Q6FGL0 G3V3R6 ENST00000254301.14 ENST00000553493.5 Q6NVH9

LGALS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review