Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 95% | 36730.47 | 437 / 459 | 93% | 193.56 | 1036 / 1118 |
| lung | 96% | 45590.44 | 553 / 578 | 86% | 133.07 | 990 / 1155 |
| thymus | 78% | 31394.57 | 508 / 653 | 88% | 256.81 | 532 / 605 |
| bladder | 90% | 30085.14 | 19 / 21 | 75% | 116.53 | 378 / 504 |
| prostate | 74% | 17972.24 | 181 / 245 | 91% | 192.48 | 458 / 502 |
| kidney | 78% | 23223.79 | 69 / 89 | 79% | 185.33 | 711 / 901 |
| uterus | 81% | 29875.35 | 138 / 170 | 73% | 129.26 | 336 / 459 |
| skin | 88% | 38488.12 | 1588 / 1809 | 52% | 60.54 | 245 / 472 |
| intestine | 62% | 17539.16 | 598 / 966 | 64% | 76.03 | 336 / 527 |
| esophagus | 57% | 12470.93 | 824 / 1445 | 66% | 71.32 | 121 / 183 |
| ovary | 44% | 11778.28 | 80 / 180 | 77% | 118.38 | 333 / 430 |
| stomach | 52% | 17566.84 | 188 / 359 | 69% | 78.70 | 196 / 286 |
| pancreas | 21% | 2275.45 | 68 / 328 | 92% | 220.60 | 164 / 178 |
| adipose | 99% | 58121.78 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 44% | 8751.17 | 113 / 258 | 53% | 80.56 | 121 / 230 |
| blood vessel | 96% | 56716.23 | 1282 / 1335 | 0% | 0 | 0 / 0 |
| liver | 54% | 10240.58 | 123 / 226 | 41% | 41.35 | 166 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 55.15 | 30 / 45 |
| heart | 65% | 20542.31 | 557 / 861 | 0% | 0 | 0 / 0 |
| brain | 4% | 507.86 | 106 / 2642 | 53% | 70.58 | 373 / 705 |
| spleen | 54% | 12756.02 | 130 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 30.25 | 12 / 29 |
| muscle | 30% | 4442.96 | 241 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 2.74 | 4 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002041 | Biological process | intussusceptive angiogenesis |
| GO_0033690 | Biological process | positive regulation of osteoblast proliferation |
| GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
| GO_0010811 | Biological process | positive regulation of cell-substrate adhesion |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0003181 | Biological process | atrioventricular valve morphogenesis |
| GO_0060710 | Biological process | chorio-allantoic fusion |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0007155 | Biological process | cell adhesion |
| GO_0003281 | Biological process | ventricular septum development |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0072593 | Biological process | reactive oxygen species metabolic process |
| GO_2000304 | Biological process | positive regulation of ceramide biosynthetic process |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0044319 | Biological process | wound healing, spreading of cells |
| GO_0003278 | Biological process | apoptotic process involved in heart morphogenesis |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0061036 | Biological process | positive regulation of cartilage development |
| GO_0060591 | Biological process | chondroblast differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005615 | Cellular component | extracellular space |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005201 | Molecular function | extracellular matrix structural constituent |
| GO_0005178 | Molecular function | integrin binding |
| GO_0019838 | Molecular function | growth factor binding |
| GO_0050840 | Molecular function | extracellular matrix binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCN1 |
| Protein name | CYR61 protein CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) Cellular communication network factor 1 CCN family member 1 (Cellular communication network factor 1) (Protein CYR61) |
| Synonyms | CYR61 IGFBP10 GIG1 hCG_23652 |
| Description | FUNCTION: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. . |
| Accessions | Q9UID7 A0A6Q8PGQ1 O00622 ENST00000675083.1 ENST00000451137.7 Q6FI18 |
