ZP4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZP4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZP4 at tissue level.

III. Associated gene sets

GO_0002922Biological processpositive regulation of humoral immune response
GO_0007339Biological processbinding of sperm to zona pellucida
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0060468Biological processprevention of polyspermy
GO_2000344Biological processpositive regulation of acrosome reaction
GO_2000360Biological processnegative regulation of binding of sperm to zona pellucida
GO_0060478Biological processacrosomal vesicle exocytosis
GO_0035805Cellular componentegg coat
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005886Cellular componentplasma membrane
GO_0035804Molecular functionstructural constituent of egg coat
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0032190Molecular functionacrosin binding

IV. Literature review

[source]
Gene nameZP4
Protein nameZona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]
SynonymsZPB
DescriptionFUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

AccessionsENST00000366570.5
Q12836
ENST00000611898.4