Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 12 studies | 33% ± 15% | |
| oligodendrocyte precursor cell | 10 studies | 39% ± 17% | |
| retinal pigment epithelial cell | 5 studies | 36% ± 14% | |
| basal cell | 3 studies | 32% ± 13% | |
| ependymal cell | 3 studies | 33% ± 8% | |
| oligodendrocyte | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of BMP7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 3087.92 | 2598 / 2642 | 99% | 92.17 | 700 / 705 |
| thymus | 100% | 5813.15 | 651 / 653 | 98% | 86.89 | 591 / 605 |
| esophagus | 60% | 1385.54 | 871 / 1445 | 67% | 45.45 | 123 / 183 |
| prostate | 84% | 1095.05 | 207 / 245 | 34% | 6.42 | 169 / 502 |
| ureter | 0% | 0 | 0 / 0 | 100% | 53.13 | 1 / 1 |
| skin | 72% | 2512.90 | 1295 / 1809 | 24% | 13.92 | 114 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 54.82 | 43 / 45 |
| kidney | 83% | 950.64 | 74 / 89 | 9% | 2.94 | 77 / 901 |
| intestine | 36% | 288.09 | 349 / 966 | 54% | 23.57 | 284 / 527 |
| bladder | 48% | 1083.14 | 10 / 21 | 42% | 18.36 | 212 / 504 |
| adrenal gland | 13% | 152.44 | 34 / 258 | 63% | 76.64 | 146 / 230 |
| ovary | 1% | 7.37 | 2 / 180 | 74% | 59.91 | 320 / 430 |
| uterus | 16% | 231.25 | 27 / 170 | 59% | 40.50 | 269 / 459 |
| lung | 23% | 148.02 | 134 / 578 | 43% | 26.74 | 501 / 1155 |
| heart | 65% | 1134.60 | 560 / 861 | 0% | 0 | 0 / 0 |
| stomach | 19% | 121.51 | 70 / 359 | 40% | 19.07 | 114 / 286 |
| breast | 14% | 88.06 | 63 / 459 | 19% | 5.65 | 208 / 1118 |
| pancreas | 2% | 13.12 | 7 / 328 | 17% | 3.97 | 30 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 16.58 | 5 / 29 |
| adipose | 12% | 102.47 | 150 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.48 | 3 / 80 |
| blood vessel | 2% | 18.00 | 33 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.61 | 10 / 406 |
| spleen | 1% | 8.73 | 3 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.57 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0061384 | Biological process | heart trabecula morphogenesis |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_0001656 | Biological process | metanephros development |
| GO_0042325 | Biological process | regulation of phosphorylation |
| GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
| GO_1900106 | Biological process | positive regulation of hyaluranon cable assembly |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0001707 | Biological process | mesoderm formation |
| GO_1905312 | Biological process | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO_0048738 | Biological process | cardiac muscle tissue development |
| GO_0001501 | Biological process | skeletal system development |
| GO_0060686 | Biological process | negative regulation of prostatic bud formation |
| GO_0060037 | Biological process | pharyngeal system development |
| GO_0010664 | Biological process | negative regulation of striated muscle cell apoptotic process |
| GO_0030858 | Biological process | positive regulation of epithelial cell differentiation |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0001657 | Biological process | ureteric bud development |
| GO_0045839 | Biological process | negative regulation of mitotic nuclear division |
| GO_0043434 | Biological process | response to peptide hormone |
| GO_0048596 | Biological process | embryonic camera-type eye morphogenesis |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_1901145 | Biological process | mesenchymal cell apoptotic process involved in nephron morphogenesis |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0060710 | Biological process | chorio-allantoic fusion |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0003344 | Biological process | pericardium morphogenesis |
| GO_0001823 | Biological process | mesonephros development |
| GO_1900006 | Biological process | positive regulation of dendrite development |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_0072136 | Biological process | metanephric mesenchymal cell proliferation involved in metanephros development |
| GO_0070487 | Biological process | monocyte aggregation |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0051216 | Biological process | cartilage development |
| GO_0072125 | Biological process | negative regulation of glomerular mesangial cell proliferation |
| GO_0032355 | Biological process | response to estradiol |
| GO_0060445 | Biological process | branching involved in salivary gland morphogenesis |
| GO_0036305 | Biological process | ameloblast differentiation |
| GO_0072134 | Biological process | nephrogenic mesenchyme morphogenesis |
| GO_0060411 | Biological process | cardiac septum morphogenesis |
| GO_2000121 | Biological process | regulation of removal of superoxide radicals |
| GO_1901223 | Biological process | negative regulation of non-canonical NF-kappaB signal transduction |
| GO_0048812 | Biological process | neuron projection morphogenesis |
| GO_0060485 | Biological process | mesenchyme development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0034116 | Biological process | positive regulation of heterotypic cell-cell adhesion |
| GO_0060687 | Biological process | regulation of branching involved in prostate gland morphogenesis |
| GO_1905069 | Biological process | allantois development |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0033280 | Biological process | response to vitamin D |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0003272 | Biological process | endocardial cushion formation |
| GO_0048754 | Biological process | branching morphogenesis of an epithelial tube |
| GO_0048762 | Biological process | mesenchymal cell differentiation |
| GO_0072133 | Biological process | metanephric mesenchyme morphogenesis |
| GO_0072040 | Biological process | negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| GO_0060272 | Biological process | embryonic skeletal joint morphogenesis |
| GO_0009880 | Biological process | embryonic pattern specification |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0090336 | Biological process | positive regulation of brown fat cell differentiation |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0030902 | Biological process | hindbrain development |
| GO_0001503 | Biological process | ossification |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0016358 | Biological process | dendrite development |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0021502 | Biological process | neural fold elevation formation |
| GO_0050768 | Biological process | negative regulation of neurogenesis |
| GO_0007411 | Biological process | axon guidance |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0031982 | Cellular component | vesicle |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| Gene name | BMP7 |
| Protein name | Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa) Bone morphogenetic protein 7 (Osteogenic protein 1), isoform CRA_b (cDNA FLJ78019, highly similar to Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1), mRNA) (cDNA, FLJ92758, Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1)(BMP7), mRNA) Bone morphogenetic protein 7 |
| Synonyms | OP1 hCG_40100 |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis . Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A . Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes . For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor . Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors . Promotes the expression of HAMP, this is repressed by its interaction with ERFE . . |
| Accessions | B1AKZ9 A0A077CY02 ENST00000450594.6 H0Y4B5 Q9H2W7 ENST00000395863.8 ENST00000395864.7 ENST00000433911.1 P18075 Q9NQQ8 B1AL00 A8K571 |
