NPNT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0001657Biological processureteric bud development
GO_0001658Biological processbranching involved in ureteric bud morphogenesis
GO_0033631Biological processcell-cell adhesion mediated by integrin
GO_0007160Biological processcell-matrix adhesion
GO_0045184Biological processestablishment of protein localization
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0030198Biological processextracellular matrix organization
GO_0097195Biological processpilomotor reflex
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0045987Biological processpositive regulation of smooth muscle contraction
GO_0051145Biological processsmooth muscle cell differentiation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0030485Cellular componentsmooth muscle contractile fiber
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005604Cellular componentbasement membrane
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005178Molecular functionintegrin binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameNPNT
Protein nameNephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)
Nephronectin
SynonymsUNQ295/PRO334
EGFL6L
POEM
DescriptionFUNCTION: Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). .

AccessionsD6RE63
ENST00000453617.6 [Q6UXI9-6]
ENST00000506666.5 [Q6UXI9-4]
ENST00000427316.6 [Q6UXI9-3]
H0YA60
H0YAK9
ENST00000379987.7 [Q6UXI9-1]
ENST00000504304.5
Q6UXI9
ENST00000514622.5 [Q6UXI9-5]
ENST00000504787.1
ENST00000503451.5
ENST00000505917.1
ENST00000514837.1
D6RH31
H0Y8M1
ENST00000305572.12 [Q6UXI9-2]