I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| chondrocyte | 4 studies | 51% ± 13% | |
| epithelial cell | 3 studies | 36% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| chondrocyte | 4 studies | 51% ± 13% | |
| epithelial cell | 3 studies | 36% ± 6% |
Insufficient scRNA-seq data for expression of COL2A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 88% | 369.73 | 159 / 180 | 29% | 7.62 | 126 / 430 |
| prostate | 65% | 39.63 | 159 / 245 | 49% | 42.56 | 247 / 502 |
| breast | 56% | 80.03 | 256 / 459 | 34% | 44.11 | 385 / 1118 |
| brain | 78% | 60.69 | 2062 / 2642 | 9% | 5.49 | 61 / 705 |
| stomach | 79% | 2279.95 | 282 / 359 | 8% | 5.52 | 22 / 286 |
| intestine | 63% | 38.99 | 612 / 966 | 6% | 2.60 | 30 / 527 |
| uterus | 38% | 58.79 | 64 / 170 | 22% | 29.17 | 99 / 459 |
| adrenal gland | 39% | 14.68 | 101 / 258 | 5% | 2.63 | 11 / 230 |
| eye | 0% | 0 | 0 / 0 | 43% | 13.38 | 34 / 80 |
| skin | 23% | 4.91 | 420 / 1809 | 18% | 22.17 | 86 / 472 |
| spleen | 26% | 7.09 | 63 / 241 | 0% | 0 | 0 / 0 |
| lung | 13% | 57.67 | 77 / 578 | 13% | 5.79 | 147 / 1155 |
| esophagus | 12% | 5.22 | 174 / 1445 | 10% | 2.22 | 19 / 183 |
| liver | 3% | 0.67 | 6 / 226 | 14% | 9.87 | 57 / 406 |
| thymus | 4% | 1.14 | 28 / 653 | 9% | 2.83 | 55 / 605 |
| peripheral blood | 13% | 3.19 | 118 / 929 | 0% | 0 | 0 / 0 |
| muscle | 13% | 3.11 | 101 / 803 | 0% | 0 | 0 / 0 |
| adipose | 12% | 4.68 | 143 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 9% | 2.49 | 8 / 89 | 1% | 0.30 | 8 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 1.09 | 4 / 45 |
| blood vessel | 9% | 5.10 | 115 / 1335 | 0% | 0 | 0 / 0 |
| heart | 8% | 1.56 | 67 / 861 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 5% | 3.19 | 24 / 504 |
| pancreas | 2% | 0.30 | 6 / 328 | 3% | 0.45 | 5 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0006029 | Biological process | proteoglycan metabolic process |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0097065 | Biological process | anterior head development |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0060174 | Biological process | limb bud formation |
| GO_0001958 | Biological process | endochondral ossification |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0060272 | Biological process | embryonic skeletal joint morphogenesis |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0007417 | Biological process | central nervous system development |
| GO_0042472 | Biological process | inner ear morphogenesis |
| GO_0001501 | Biological process | skeletal system development |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0001894 | Biological process | tissue homeostasis |
| GO_0001502 | Biological process | cartilage condensation |
| GO_0030903 | Biological process | notochord development |
| GO_0051216 | Biological process | cartilage development |
| GO_0060351 | Biological process | cartilage development involved in endochondral bone morphogenesis |
| GO_0071599 | Biological process | otic vesicle development |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005585 | Cellular component | collagen type II trimer |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005592 | Cellular component | collagen type XI trimer |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0030020 | Molecular function | extracellular matrix structural constituent conferring tensile strength |
| GO_0042289 | Molecular function | MHC class II protein binding |
| GO_0048407 | Molecular function | platelet-derived growth factor binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0043394 | Molecular function | proteoglycan binding |
| Gene name | COL2A1 |
| Protein name | Alternative protein COL2A1 Collagen alpha 1 type II (Pro-alpha 1(II) collagen) Alpha-1 collagen type II Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] |
| Synonyms | |
| Description | FUNCTION: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
| Accessions | Q2V4X9 Q16561 ENST00000337299.7 [P02458-1] L8EBB9 P02458 ENST00000380518.8 [P02458-2] |
