PKM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0032869Biological processcellular response to insulin stimulus
GO_0012501Biological processprogrammed cell death
GO_0006096Biological processglycolytic process
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0061621Biological processcanonical glycolysis
GO_0005576Cellular componentextracellular region
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_1903561Cellular componentextracellular vesicle
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0004743Molecular functionpyruvate kinase activity
GO_0045296Molecular functioncadherin binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0003729Molecular functionmRNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0030955Molecular functionpotassium ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePKM
Protein namePyruvate kinase M1/2
pyruvate kinase (EC 2.7.1.40)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Pyruvate kinase (EC 2.7.1.40)
SynonymsPK3
PK2
OIP3
PKM2
hCG_2005199
DescriptionFUNCTION: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP . The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production . The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival . .; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity . In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase . Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase . Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription . Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis . Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells . .; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth . In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity . .

AccessionsENST00000698740.1
ENST00000565154.6
ENST00000562997.5
H3BTN5
P14618
ENST00000335181.10 [P14618-1]
ENST00000567087.5
ENST00000698741.1
ENST00000569857.5
ENST00000568459.5 [P14618-2]
H3BUW1
ENST00000561609.5
A0A804F729
A0A8V8TNX9
H3BQZ3
ENST00000566809.1
ENST00000564178.5
A0A8V8TMM5
ENST00000569050.1
H3BTJ2
H3BT25
ENST00000567118.5
ENST00000319622.10 [P14618-2]
H3BU13
B4DNK4
H3BN34
A0A804F6T5
ENST00000565184.6
ENST00000389093.7
H3BQ34