CTSD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	46 studies	65% ± 24%	Explore
natural killer cell	35 studies	46% ± 18%	Explore
endothelial cell	29 studies	31% ± 12%	Explore
classical monocyte	28 studies	65% ± 20%	Explore
mast cell	26 studies	55% ± 22%	Explore
fibroblast	26 studies	36% ± 14%	Explore
epithelial cell	23 studies	46% ± 22%	Explore
monocyte	21 studies	57% ± 19%	Explore
non-classical monocyte	21 studies	58% ± 18%	Explore
CD8-positive, alpha-beta T cell	21 studies	33% ± 12%	Explore
pericyte	20 studies	37% ± 18%	Explore
basal cell	19 studies	46% ± 21%	Explore
T cell	18 studies	26% ± 7%	Explore
smooth muscle cell	17 studies	28% ± 11%	Explore
endothelial cell of lymphatic vessel	16 studies	46% ± 16%	Explore
ciliated cell	16 studies	58% ± 13%	Explore
conventional dendritic cell	16 studies	41% ± 19%	Explore
connective tissue cell	15 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	15 studies	28% ± 10%	Explore
plasmacytoid dendritic cell	14 studies	38% ± 10%	Explore
gamma-delta T cell	14 studies	37% ± 12%	Explore
myeloid cell	14 studies	63% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	48% ± 21%	Explore
mature NK T cell	13 studies	40% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	42% ± 19%	Explore
regulatory T cell	12 studies	31% ± 10%	Explore
astrocyte	11 studies	33% ± 12%	Explore
neutrophil	10 studies	41% ± 17%	Explore
secretory cell	10 studies	46% ± 16%	Explore
dendritic cell	10 studies	40% ± 18%	Explore
plasma cell	9 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	35% ± 8%	Explore
capillary endothelial cell	8 studies	23% ± 5%	Explore
leukocyte	8 studies	37% ± 14%	Explore
type I pneumocyte	7 studies	48% ± 13%	Explore
type II pneumocyte	7 studies	43% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	24% ± 6%	Explore
abnormal cell	7 studies	43% ± 24%	Explore
endothelial cell of artery	7 studies	24% ± 6%	Explore
enterocyte	7 studies	57% ± 20%	Explore
goblet cell	7 studies	44% ± 15%	Explore
mesothelial cell	7 studies	33% ± 18%	Explore
progenitor cell	7 studies	39% ± 17%	Explore
mucosal invariant T cell	7 studies	30% ± 5%	Explore
myofibroblast cell	7 studies	39% ± 17%	Explore
innate lymphoid cell	7 studies	34% ± 12%	Explore
oligodendrocyte	7 studies	23% ± 9%	Explore
alveolar macrophage	6 studies	93% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	35% ± 8%	Explore
club cell	6 studies	61% ± 18%	Explore
ionocyte	6 studies	50% ± 8%	Explore
respiratory goblet cell	6 studies	68% ± 18%	Explore
mononuclear phagocyte	6 studies	51% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	33% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	39% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	57% ± 24%	Explore
microglial cell	6 studies	40% ± 14%	Explore
intermediate monocyte	6 studies	67% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	30% ± 10%	Explore
platelet	5 studies	30% ± 9%	Explore
renal alpha-intercalated cell	5 studies	85% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	65% ± 34%	Explore
vein endothelial cell	5 studies	21% ± 4%	Explore
amacrine cell	5 studies	35% ± 10%	Explore
endothelial cell of vascular tree	5 studies	23% ± 8%	Explore
neuron	5 studies	28% ± 14%	Explore
granulocyte	5 studies	48% ± 23%	Explore
oligodendrocyte precursor cell	5 studies	25% ± 11%	Explore
deuterosomal cell	4 studies	32% ± 3%	Explore
duct epithelial cell	4 studies	64% ± 4%	Explore
plasmablast	4 studies	39% ± 5%	Explore
pancreatic A cell	4 studies	30% ± 8%	Explore
type B pancreatic cell	4 studies	32% ± 10%	Explore
exhausted T cell	4 studies	53% ± 8%	Explore
hematopoietic precursor cell	4 studies	43% ± 15%	Explore
kidney connecting tubule epithelial cell	4 studies	85% ± 11%	Explore
OFF-bipolar cell	4 studies	33% ± 20%	Explore
retinal ganglion cell	4 studies	81% ± 17%	Explore
brush cell	4 studies	24% ± 8%	Explore
retina horizontal cell	4 studies	46% ± 12%	Explore
retinal pigment epithelial cell	4 studies	66% ± 33%	Explore
mucus secreting cell	4 studies	36% ± 14%	Explore
melanocyte	4 studies	56% ± 22%	Explore
group 3 innate lymphoid cell	4 studies	47% ± 18%	Explore
T-helper 17 cell	4 studies	21% ± 2%	Explore
squamous epithelial cell	3 studies	58% ± 18%	Explore
GABAergic neuron	3 studies	34% ± 14%	Explore
podocyte	3 studies	68% ± 7%	Explore
intestinal crypt stem cell	3 studies	30% ± 4%	Explore
transit amplifying cell	3 studies	29% ± 8%	Explore
retinal bipolar neuron	3 studies	38% ± 8%	Explore
GABAergic amacrine cell	3 studies	26% ± 10%	Explore
renal principal cell	3 studies	87% ± 5%	Explore
extravillous trophoblast	3 studies	32% ± 13%	Explore
placental villous trophoblast	3 studies	48% ± 9%	Explore
common myeloid progenitor	3 studies	37% ± 11%	Explore
hematopoietic stem cell	3 studies	34% ± 6%	Explore
lymphocyte	3 studies	47% ± 13%	Explore
megakaryocyte	3 studies	44% ± 10%	Explore
retinal cone cell	3 studies	35% ± 11%	Explore
retinal rod cell	3 studies	22% ± 6%	Explore
adventitial cell	3 studies	44% ± 15%	Explore
serous secreting cell	3 studies	35% ± 17%	Explore
tissue-resident macrophage	3 studies	72% ± 27%	Explore
intraepithelial lymphocyte	3 studies	30% ± 5%	Explore
Mueller cell	3 studies	35% ± 4%	Explore
rod bipolar cell	3 studies	32% ± 13%	Explore
inflammatory macrophage	3 studies	71% ± 5%	Explore
endothelial cell of sinusoid	3 studies	54% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	40% ± 10%	Explore
myoepithelial cell	3 studies	41% ± 12%	Explore
keratinocyte	3 studies	32% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 4%	Explore
monocyte-derived dendritic cell	3 studies	27% ± 4%	Explore
pancreatic ductal cell	3 studies	75% ± 3%	Explore
enteroendocrine cell	3 studies	37% ± 14%	Explore
glial cell	3 studies	33% ± 11%	Explore
hepatocyte	3 studies	55% ± 24%	Explore
T follicular helper cell	3 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	31% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	29% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	44% ± 18%	Explore
peripheral blood	17 studies	35% ± 10%	Explore
intestine	13 studies	28% ± 15%	Explore
brain	9 studies	33% ± 13%	Explore
kidney	9 studies	40% ± 18%	Explore
eye	7 studies	35% ± 14%	Explore
liver	6 studies	39% ± 14%	Explore
placenta	5 studies	37% ± 13%	Explore
uterus	5 studies	43% ± 16%	Explore
pancreas	4 studies	35% ± 3%	Explore
breast	4 studies	27% ± 9%	Explore
bone marrow	3 studies	30% ± 13%	Explore
adrenal gland	3 studies	35% ± 10%	Explore
esophagus	3 studies	41% ± 19%	Explore
lymph node	3 studies	41% ± 35%	Explore
skin	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	40612.70	226 / 226	100%	408.46	406 / 406
thymus	100%	23949.91	651 / 653	100%	247.87	603 / 605
kidney	100%	88790.33	89 / 89	99%	540.81	894 / 901
prostate	100%	22609.07	245 / 245	99%	168.50	498 / 502
adrenal gland	100%	101991.29	258 / 258	99%	285.01	227 / 230
skin	100%	33004.91	1808 / 1809	99%	409.80	466 / 472
esophagus	99%	20922.42	1433 / 1445	99%	148.11	182 / 183
pancreas	100%	19056.01	327 / 328	99%	357.53	176 / 178
uterus	100%	17941.96	170 / 170	98%	259.54	450 / 459
lung	100%	68629.24	578 / 578	98%	309.42	1129 / 1155
intestine	100%	28921.37	965 / 966	98%	190.91	515 / 527
breast	100%	29801.60	459 / 459	97%	334.33	1088 / 1118
bladder	100%	31666.95	21 / 21	97%	304.51	487 / 504
stomach	100%	26359.11	359 / 359	96%	172.59	275 / 286
ovary	99%	13642.70	178 / 180	94%	139.14	404 / 430
brain	95%	15070.45	2513 / 2642	92%	122.95	650 / 705
adipose	100%	36990.11	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	509.33	80 / 80
lymph node	0%	0	0 / 0	100%	616.15	29 / 29
spleen	100%	63609.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	262.09	45 / 45
ureter	0%	0	0 / 0	100%	170.50	1 / 1
blood vessel	100%	43242.35	1330 / 1335	0%	0	0 / 0
muscle	99%	35162.82	796 / 803	0%	0	0 / 0
heart	97%	34525.99	836 / 861	0%	0	0 / 0
peripheral blood	86%	47062.18	800 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000045	Biological process	autophagosome assembly
GO_0038020	Biological process	insulin receptor recycling
GO_0070201	Biological process	regulation of establishment of protein localization
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0042159	Biological process	lipoprotein catabolic process
GO_0006508	Biological process	proteolysis
GO_1901143	Biological process	insulin catabolic process
GO_0019886	Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0045121	Cellular component	membrane raft
GO_0035580	Cellular component	specific granule lumen
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_1904724	Cellular component	tertiary granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0010008	Cellular component	endosome membrane
GO_0043202	Cellular component	lysosomal lumen
GO_0005765	Cellular component	lysosomal membrane
GO_0042470	Cellular component	melanosome
GO_0031904	Cellular component	endosome lumen
GO_0070001	Molecular function	aspartic-type peptidase activity
GO_0008233	Molecular function	peptidase activity
GO_0004190	Molecular function	aspartic-type endopeptidase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CTSD
Protein name	Cathepsin D isoform 2 Cathepsin D (EC 3.4.23.5) Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] Cathepsin D
Synonyms	HEL-S-130P CPSD hCG_49857
Description	FUNCTION: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation . Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. .
Accessions	F8W787 P07339 ENST00000637815.2 A0A1B0GW44 ENST00000433655.6 ENST00000429746.2 ENST00000236671.7 ENST00000637387.1 ENST00000678991.1 A0A0S2Z3L4 C9JH19 A0A1B0GVP3 ENST00000367196.4 A0A1B0GV23 ENST00000636571.1 ENST00000637915.1 A0A1B0GWE8 ENST00000636843.1 ENST00000438213.6 V9HWI3 F8WD96 A0A7I2V2N3 A0A1B0GVD5

CTSD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review