PXDN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0001525Biological processangiogenesis
GO_0098869Biological processcellular oxidant detoxification
GO_0042744Biological processhydrogen peroxide catabolic process
GO_0030198Biological processextracellular matrix organization
GO_0070207Biological processprotein homotrimerization
GO_0007155Biological processcell adhesion
GO_0001654Biological processeye development
GO_0006955Biological processimmune response
GO_0071711Biological processbasement membrane organization
GO_0030199Biological processcollagen fibril organization
GO_0006979Biological processresponse to oxidative stress
GO_0001960Biological processnegative regulation of cytokine-mediated signaling pathway
GO_0070831Biological processbasement membrane assembly
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0005604Cellular componentbasement membrane
GO_0004601Molecular functionperoxidase activity
GO_0140825Molecular functionlactoperoxidase activity
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0043237Molecular functionlaminin-1 binding
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0016684Molecular functionoxidoreductase activity, acting on peroxide as acceptor
GO_0005152Molecular functioninterleukin-1 receptor antagonist activity

IV. Literature review

[source]
Gene namePXDN
Protein namePXDN protein
Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment]
Peroxidasin
SynonymsPXD01
VPO
PRG2
VPO1
KIAA0230
MG50
DescriptionFUNCTION: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer . In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling . Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity . In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways . Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes . In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds . Binds laminins . May play a role in the organization of eyeball structure and lens development during eye development (By similarity). .

AccessionsENST00000433670.5
H7C300
ENST00000453308.1
ENST00000425171.2
H7C3W2
ENST00000447941.5
ENST00000252804.9 [Q92626-1]
H7C1W1
Q92626
C9J4I9
Q96GF5